@article{10.2337/db18-1794-P,
    author = {PAN, RUIYAN and LI, NA and ZHAO, TINGKUN and WANG, HUAIJIE and JIANG, BIN and YAN, QINGTAO and GAO, ZHIQIN and QU, MEI-HUA},
    title = "{DJB Surgery Improved the T2DM Rats Glucose Homeostasis, Elevated the Glucose Utilization, and the GLUT3 Expression in Brain}",
    journal = {Diabetes},
    volume = {67},
    number = {Supplement_1},
    pages = {1794-P},
    year = {2018},
    month = {07},
    abstract = "{Duodenal-jejunal bypass surgery (DJB) is a experimental surgical procedure to study the mechanism of gastric surgery in T2DM treatment.Methods: T2DM rats induced by high glucose high fat food and low dose streptozotocin (STZ) injection were randomly divided into 2 groups: T2DM group and DJB surgery group (T2DM-DJB).Wistar rats were used as normal control. The fasting blood glucose and HbA1C were measured. Glucose utilizationin the brain was detected by small animal positron emission tomography (PET) using [18F]-fluorodeoxyglucose ([18F]-FDG).GLUT1, GLUT3 expression in the brain were measured by Q-RT-PCR.Results:DJB surgery significantly decreased the fasting blood glucose and Hb1Ac of the T2DM rats. [18F]-FDG uptake (standardized uptake values (SUV)mean)in the brain was elevated siginificantly 4 weeks after DJB (Wistar vs. T2DM vs. T2DM-DJB: SUVmean value 1.30±0.27 vs. 0.59±0.10 vs. 1.55±0.31, P\\<0.001). Q-RT-PCR showed that GLUT3 expression in the brain significantly increased 4 weeks after DJB while T2DM rats decreased. This study indicates that the improvement of glucose utilization in the brain plays an pivotal role in DJB treatment of T2DM.R. Pan: None. N. Li: None. T. Zhao: None. H. Wang: None. B. Jiang: None. Q. Yan: None. Z. Gao: None. M. Qu: None.}",
    issn = {0012-1797},
    doi = {10.2337/db18-1794-P},
    url = {https://doi.org/10.2337/db18-1794-P},
}