This handbook provides physicians, clinicians, and educators with the indispensible, reliable information they need to successfully initiate and maintain insulin therapy in people with type 1 and type 2 diabetes. Now in its sixth edition, Practical Insulin has been revised and updated to reflect the latest American Diabetes Association Standards of Care in Diabetes.
Inside, you’ll find information about currently available insulin products, delivery methods, injection regimens, dose calculations, and more. With this guide, you can make improved glycemic control an achievable reality for the people with diabetes in your care.
Insulin: Basic Physiology and Pharmacology Available to Purchase
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Published:2023
"Insulin: Basic Physiology and Pharmacology", Practical Insulin: A Handbook for Prescribing Providers
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Insulin is produced in the pancreas within the islets of Langerhans by β-cells and is secreted in response to rising blood glucose levels and neurohormonal signaling. When functioning normally, β-cells help maintain euglycemia via endogenous release of insulin to cover basal and prandial needs. In normal physiology, “basal insulin secretion” describes the low rate of insulin release between meals that is sufficient to inhibit overproduction of glucose and ketone bodies by the liver in the fasting state. Additional bursts of insulin are released to prevent hyperglycemia in the prandial state and promote conversion of nutrients to energy for short- and long-term use and storage (see Figure 1). Although Figure 1 provides generalized statements related to physiologic insulin secretion during a given day, individual responses will vary.
