OBJECTIVE

We evaluated the performance of the iLet bionic pancreas (BP) in non-Hispanic White individuals (here referred to as “Whites”) and in Black, Hispanic, and other individuals (here collectively referred to as “Minorities”).

RESEARCH DESIGN AND METHODS

A multicenter, randomized controlled trial evaluated glycemic management with the BP versus standard of care (SC) in 161 adult and 165 pediatric participants with type 1 diabetes over 13 weeks.

RESULTS

In Whites (n = 240), the mean baseline-adjusted difference in 13-week HbA1c between the BP and SC groups was −0.45% (95% CI −0.61 to −0.29 [−4.9 mmol/mol; −6.6 to −3.1]; P < 0.001), while this difference among Minorities (n = 84) was −0.53% (−0.83 to −0.24 [−6.0 mmol/mol; −9.2 to −2.8]; P < 0.001). In Whites, the mean baseline-adjusted difference in time in range between the BP and SC groups was 10% (95% CI 7–12; P < 0.001) and in Minorities was 14% (10–18; P < 0.001).

CONCLUSIONS

The BP improves glycemic control in both Whites and Minorities and offers promise in decreasing health care disparities.

Graphical Abstract

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Clinical trial reg. no. NCT04200313, clinicaltrials.gov

This article contains supplementary material online at https://doi.org/10.2337/figshare.22221280.

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A listing of the Bionic Pancreas Research Group is provided in the supplementary material online.

© 2023 by the American Diabetes Association
2023
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