To investigate associations of plasma glycated albumin (GA) concentrations in early and midpregnancy with gestational diabetes mellitus (GDM) risk.


We measured GA concentrations using blood samples collected at 10–14 and 15–26 weeks’ gestation (GW) in 107 GDM case subjects and 214 control subjects from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. We performed generalized linear mixed-effect regression to test the mean GA difference between GDM case subjects and control subjects and conditional logistic regression to assess prospective associations between GA concentrations and GDM risk.


At 15–26 GW, mean GA was lower in GDM case subjects than control subjects (mean 11.90% [95% CI 6.42–32.76] vs. 12.46% [8.45–38.35], adjusted P value for difference = 0.004). Consistently, women with higher GA concentrations tended to have a lower GDM risk, although the associations were not statistically significant.


This study suggests that GA concentrations in midpregnancy might be lower in women who later develop GDM. Further studies are needed to identify the mechanism.

This article contains supplementary material online at https://doi.org/10.2337/figshare.25962196.

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