Plasma lipoproteins and apoproteins were compared among Chinese and American controls and noninsulin-dependent diabetic (NIDDM) subjects in the same laboratory. Apoprotein AI concentrations in Chinese subjects, both NIDDM subjects and controls (men, 147 and 158 mg/dl, respectively), were significantly higher than those in American subjects (men, 104 and 124 mg/dl, respectively). Apoprotein All concentrations, however, were comparable between Chinese and American subjects. Chinese NIDDM subjects had lower high-density lipoprotein cholesterol (HDLC), higher low-density lipoprotein cholesterol (LDLC), and higher apoprotein B levels than Chinese controls. Chinese subjects with NIDDM had HDLC and LDLC levels similar to those of American controls but trends of higher HDLC and lower LDLC compared with American subjects with NIDDM. These differences may in part explain the relatively higher incidence of atherosclerotic vascular disease in Americans.
Original Articles|
July 01 1986
comparison of Plasma Lipoproteins and Apoproteins in Chinese and American Non-Insulin-Dependent Diabetic Subjects and Controls
X-R Pan, MD;
X-R Pan, MD
Diabetes Unit Department of Endocrinology, Capital Hospital, Chinese Academy of Medical Science
Beijing, China
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C E Walden, MS;
C E Walden, MS
Department of Biostatistics, School of Public Health and Community Medicine, University of Washington
Seattle, Washington
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G R Warnick, MS;
G R Warnick, MS
Division of Metabolism, Endocrinology and Nutrition and Northwest Lipid Research Clinic, Department of Medicine, University of Washington School of Medicine
Seattle, Washington
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S-X Hu, MD;
S-X Hu, MD
Diabetes Unit Department of Endocrinology, Capital Hospital, Chinese Academy of Medical Science
Beijing, China
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J J Albers, PhD;
J J Albers, PhD
Division of Metabolism, Endocrinology and Nutrition and Northwest Lipid Research Clinic, Department of Medicine, University of Washington School of Medicine
Seattle, Washington
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M Cheung, PhD;
M Cheung, PhD
Division of Metabolism, Endocrinology and Nutrition and Northwest Lipid Research Clinic, Department of Medicine, University of Washington School of Medicine
Seattle, Washington
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E L Bierman, MD
E L Bierman, MD
Division of Metabolism, Endocrinology and Nutrition and Northwest Lipid Research Clinic, Department of Medicine, University of Washington School of Medicine
Seattle, Washington
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Address reprint requests to John Albers, PhD, Northwest Lipid Research Clinic, 326 Ninth Avenue, Seattle, WA 98104.
Citation
X-R Pan, C E Walden, G R Warnick, S-X Hu, J J Albers, M Cheung, E L Bierman; comparison of Plasma Lipoproteins and Apoproteins in Chinese and American Non-Insulin-Dependent Diabetic Subjects and Controls. Diabetes Care 1 July 1986; 9 (4): 395–400. https://doi.org/10.2337/diacare.9.4.395
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