Many drugs have been reported to interfere with copper-reduction or glucose oxidase tests used to measure urine glucose. However, only a few drugs or drug classes have been well documented to clinically interfere with these tests. The interfering drugs include ascorbic acid, β-lactam antibiotics (e.g., cephalosporins and penicillins), levodopa, and salicylates. Several other drugs may also interfere with certain urine glucose tests, but the interactions are poorly documented. These drugs include chloral hydrate, hyaluronidase, nalidixic acid, nitrofurantoin, p-aminosalicylic acid, phenazopyridine, probenecid, and X-ray contrast media. Drugs or their metabolites that are strong reducing substances produce false-positive results by the copper-reduction method and false-negative results by the glucose oxidase method. The β-lactam antibiotics interfere with copper-reduction tests by producing copper compounds of various colors that confuse interpretation of test results. Tables are provided that summarize the drug interferences discussed.
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Technical Section|
January 01 1987
Review of Drug Interference With Urine Glucose Tests
Michael D Rotblatt, PharmD;
Michael D Rotblatt, PharmD
Department of Pharmacy, Stanford University Hospital, Stanford and the Division of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco
San Francisco, California
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Mary Anne Koda-Kimble, PharmD
Mary Anne Koda-Kimble, PharmD
Department of Pharmacy, Stanford University Hospital, Stanford and the Division of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco
San Francisco, California
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Address reprint requests and correspondence to Mary Anne Koda-Kimble, PharmD, Division of Clinical Pharmacy, C-152, University of California, San Francisco, CA 94143-0622.
Citation
Michael D Rotblatt, Mary Anne Koda-Kimble; Review of Drug Interference With Urine Glucose Tests. Diabetes Care 1 January 1987; 10 (1): 103–110. https://doi.org/10.2337/diacare.10.1.103
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