Effect of Hematocrit Concentration on Blood Glucose Value Determined on Glucometer II

Nineteen patient blood samples each with modified hematocrit concentrations of ∼20, 30, 40, 50, and 60%, were assayed for their glucose concentration by the Glucometer II. Blood removal from the test strip was by the one- and two-blot techniques. The reference method was the Yellow Springs Instruments (YSI) blood glucose analyzer. Glucometer II results were falsely high for the single blot (13–59%, mean 33%) and double blot (12–41%, mean 19%) at 20% hematocrit and falsely low at 60% hematocrit for the single blot (22–44%, mean 37%) and the double blot (26–49%, mean 43%). At 40- 50% hematocrit, Glucometer II and YSI results agreed only for the one-blot technique.