The relative value of fructosamine as an alternative to glycosylated hemoglobin (HbA1) and other measures of glycemic control was assessed in 100 insulin-dependent (IDDM) and 104 non-insulin-dependent (NIDDM) diabetic patients. We measured HbA1 (by electrophoretic and affinity methods), plasma glucose, glycosylated plasma proteins, and fructosamine in blood taken at a single clinic visit. The values were compared both by correlation analysis and by considering whether the various indices of glycemic control placed the patients in the same clinical decision categories as they were in by the HbA1 (affinity) result. Fructosamine correlated moderately well with HbA1 (affinity; r = .8) and placed 71% of IDDM and 72% of NIDDM patients in the same clinical category of good, moderate, or poor control. Differences can probably be partly attributed to the different periods over which HbA1 and fructosamine reflect average glycemia and partly to imprecision.
Skip Nav Destination
Article navigation
Technical Article|
May 01 1988
Comparison of Fructosamine With Glycosylated Hemoglobin and Plasma Proteins as Measures of Glycemic Control
Lesley M Smart, MRCP;
Lesley M Smart, MRCP
Diabetic and Dietetic Department and the University Department of Clinical Chemistry
Royal Infirmary, Edinburgh, Scotland, United Kingdom
Search for other works by this author on:
Alexander F Howie, BSc;
Alexander F Howie, BSc
Diabetic and Dietetic Department and the University Department of Clinical Chemistry
Royal Infirmary, Edinburgh, Scotland, United Kingdom
Search for other works by this author on:
Robert J Young, MRCP;
Robert J Young, MRCP
Diabetic and Dietetic Department and the University Department of Clinical Chemistry
Royal Infirmary, Edinburgh, Scotland, United Kingdom
Search for other works by this author on:
Simon W Walker, MBBS;
Simon W Walker, MBBS
Diabetic and Dietetic Department and the University Department of Clinical Chemistry
Royal Infirmary, Edinburgh, Scotland, United Kingdom
Search for other works by this author on:
Basil F Clarke, FRCP;
Basil F Clarke, FRCP
Diabetic and Dietetic Department and the University Department of Clinical Chemistry
Royal Infirmary, Edinburgh, Scotland, United Kingdom
Search for other works by this author on:
Alistair F Smith, FRCP
Alistair F Smith, FRCP
Diabetic and Dietetic Department and the University Department of Clinical Chemistry
Royal Infirmary, Edinburgh, Scotland, United Kingdom
Search for other works by this author on:
Address correspondence and reprint requests to Dr. Lesley M. Smart, Diabetic and Dietetic Department, Royal Infirmary, Edinburgh EH3 9YW, Scotland, UK.
Citation
Lesley M Smart, Alexander F Howie, Robert J Young, Simon W Walker, Basil F Clarke, Alistair F Smith; Comparison of Fructosamine With Glycosylated Hemoglobin and Plasma Proteins as Measures of Glycemic Control. Diabetes Care 1 May 1988; 11 (5): 433–436. https://doi.org/10.2337/diacare.11.5.433
Download citation file: