The goal of this study was to evaluate the effects of captopril on plasma glucose concentration. The daily profiles of the plasma glucose levels were determined in 12 non-insulin-dependent diabetic normotensive subjects, treated with or without captopril at a dose of 25 mg 3 times/day. Forearm blood flow was also measured by strain-gauge plethysmography. Administration of captopril improved the daily profile of the plasma glucose level. Postprandial forearm blood flow was also augmented 2 h after a meal. These results suggest that angiotensin-converting enzyme inhibitors may improve glucose metabolism in diabetic subjects, possibly through enhancement of blood flow to skeletal muscle.
Effect of Captopril on Glucose Concentration: Possible Role of Augmented Postprandial Forearm Blood Flow
Junichi Kodama, Shigehiro Katayama, Kiyoshi Tanaka, Akira Itabashi, Shyoji Kawazu, Jun Ishii; Effect of Captopril on Glucose Concentration: Possible Role of Augmented Postprandial Forearm Blood Flow. Diabetes Care 1 November 1990; 13 (11): 1109–1111. https://doi.org/10.2337/diacare.13.11.1109
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