Islet cell antibodies (ICAs) are markers for patients at risk for insulin-dependent diabetes and are associated with progressive β-cell destruction. This prospective study was performed to estimate the incidence of these antibodies in 187 women with previous gestational diabetes. With a specific protein A monoclonal antibody (MoAb) assay, the incidence of ICAs was only 1.6% (3 of 187). Oral and intravenous glucose tolerance tests were performed in these 3 women and compared with 6 women with previous gestational diabetes without ICAs and 5 control women. Glucose tolerance was impaired only in the 3 women with ICAs, who also had an increase (P < 0.03) in fasting plasma glucose and a decrease (P < 0.03) in early first-phase insulin response. We conclude that the more specific MoAb method indicates a lower incidence of ICA in women with a history of gestational diabetes than previously reported and that a decreased first-phase insulin response is associated with the presence of ICAs, suggesting progressive islet cell damage.
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Original Articles|
May 01 1990
Incidence and Significance of Islet Cell Antibodies in Women With Previous Gestational Diabetes
Patrick M Catalano, MD;
Patrick M Catalano, MD
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Endocrine-Metabolic Unit, Department of Medicine, The University of Vermont College of Medicine
Burlington, Vermont
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Elaine D Tyzbir, MS;
Elaine D Tyzbir, MS
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Endocrine-Metabolic Unit, Department of Medicine, The University of Vermont College of Medicine
Burlington, Vermont
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Ethan A H Sims, MD
Ethan A H Sims, MD
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Endocrine-Metabolic Unit, Department of Medicine, The University of Vermont College of Medicine
Burlington, Vermont
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Address correspondence and reprint requests to P. M. Catalano, MD, Department of Ob/Gyn, Case Western Reserve University, Metro Health Medical Center, 3395 Scranton Road, Cleveland, OH 44109.
Diabetes Care 1990;13(5):478–482
Article history
Received:
August 14 1989
Revision Received:
December 14 1989
Accepted:
December 14 1989
PubMed:
2190774
Citation
Patrick M Catalano, Elaine D Tyzbir, Ethan A H Sims; Incidence and Significance of Islet Cell Antibodies in Women With Previous Gestational Diabetes. Diabetes Care 1 May 1990; 13 (5): 478–482. https://doi.org/10.2337/diacare.13.5.478
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