Our objective was to determine whether 1) hydrogenated starch hydrolysates (HSHs), bulking/sweetening agents used in hard candies, produce a diminished postmeal glycemic response relative to glucose in individuals with and without diabetes and 2) any diminished glycemia is secondary to altered carbohydrate absorption. This study followed a randomized double-blind crossover design and was performed in 12 individuals with diabetes (6 non-insulin dependent, 6 insulin dependent) and 6 nondiabetic individuals. Each group consisted of 3 men and 3 women, none with known neuropathy. After an overnight fast, each subject was challenged with 50 g of glucose, HSH 5875 (7% sorbitol/60% maltitol), and HSH 6075 (14% sorbitol/78% hydrogenated maltooligosaccharides)/1.73 m2 of body surface area in random order on 3 successive days. Individuals with diabetes were maintained on continuous subcutaneous insulin infusion throughout the study to achieve prechallenge glucose levels between 4.5 and 6.7 mM. For all groups, the order of plasma glucose responses over 5 h postchallenge was glucose>HSH 6075>HSH 5875, P < 0.001 (glucose vs. HSH). Pooled data for all groups for areas under the curve confirmed that HSH 6075 resulted in greater glycemia than HSH 5875 (P < 0.05). This was reflected in the order of C-peptide responses seen in the nondiabetic and non-insulindependent groups (glucose>HSH 6075>HSH 5875, P < 0.001). Breath H2 after glucose was low, whereas HSH 5875 > HSH 6075 (P = 0.003). Gastric distress was noticed with all products. HSH ingestion as a single carbohydrate ingredient results in decreased glycemia relative to glucose in individuals with and without diabetes. Decreased glycemia results from altered small intestinal carbohydrate absorption. HSH as a single ingredient appears to be a suitable product for consumption by individuals with diabetes mellitus.
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Original Articles|
July 01 1990
Metabolic Response to Oral Challenge of Hydrogenated Starch Hydrolysate Versus Glucose In Diabetes
Madelyn L Wheeler, MS, RD, CDE;
Madelyn L Wheeler, MS, RD, CDE
Diabetes Research and Training Center, Indiana University Medical Center
Indianapolis, Indiana
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S Edwin Fineberg, MD;
S Edwin Fineberg, MD
Diabetes Research and Training Center, Indiana University Medical Center
Indianapolis, Indiana
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Reid Gibson, BS;
Reid Gibson, BS
Diabetes Research and Training Center, Indiana University Medical Center
Indianapolis, Indiana
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Naomi Fineberg, PhD
Naomi Fineberg, PhD
Diabetes Research and Training Center, Indiana University Medical Center
Indianapolis, Indiana
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Address correspondence and reprint requests to Madelyn L. Wheeler, MS, RD, CDE, Indiana University Medical Center, DRTC, RHC 234, 1001 West 10th Street, Indianapolis, IN 46202.
Diabetes Care 1990;13(7):733–740
Article history
Received:
September 28 1989
Revision Received:
February 14 1990
Accepted:
February 14 1990
PubMed:
2201496
Citation
Madelyn L Wheeler, S Edwin Fineberg, Reid Gibson, Naomi Fineberg; Metabolic Response to Oral Challenge of Hydrogenated Starch Hydrolysate Versus Glucose In Diabetes. Diabetes Care 1 July 1990; 13 (7): 733–740. https://doi.org/10.2337/diacare.13.7.733
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