Total glycosylated hemoglobin (HbA1) and fructosamine were evaluated as screening tools for detection of glucose-tolerance abnormalities in 144 asymptomatic subjects undergoing a 75-g oral glucose tolerance test. Subjects were classified according to World Health Organization criteria as having normal (n = 78), impaired (n = 40), or diabetic (n = 26) glucose tolerance. We found good specificity for HbA1 and fructosamine (100 and 97%, respectively) but low sensitivity (15 and 19%, respectively). At the intersection of the curves of sensitivity and specificity drawn from various thresholds of normality, both sensitivity and specificity were 75% for HbA1 and 55% for fructosamine. Thus, neither HbA1 nor fructosamine seems to be suitable for the diagnosis of mild abnormalities in glucose tolerance.
Comparison of HbA1 and Fructosamine in Diagnosis of Glucose-Tolerance Abnormalities
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Pierre Jean Guillausseau, Marie-Aline Charles, Françoise Paolaggi, José Timsit, Philippe Chanson, Jacqueline Peynet, Valérie Godard, Eveline Eschwege, François Rousselet, Jean Lubetzki; Comparison of HbA1 and Fructosamine in Diagnosis of Glucose-Tolerance Abnormalities. Diabetes Care 1 August 1990; 13 (8): 898–900. https://doi.org/10.2337/diacare.13.8.898
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