The application of epidemiology to the study of non-insulin-dependent diabetes mellitus (NIDDM) is providing new insights into many aspects of this major public-health problem, including its natural history, prevalence, incidence, morbidity, and mortality in diverse populations around the globe. The main impetus came from the late Kelly West's book Epidemiology of Diabetes and its Vascular Lesions. These studies are providing direction for research into the possible moleculardefect or defects and biochemical mechanism or mechanisms underlying NIDDM and important information on the extrinsic (social, cultural, environmental) risk determinants. Studies have highlighted the importance of regional adipose tissue distribution, particularly upper-body obesity, and physical inactivity in enhancing risk of NIDDM. These findings have important implications for the primary prevention of NIDDM, particularly in populations with increased genetic susceptibility such as Polynesians, Micronesians, American and Asian Indians, Mexican Americans, and Australian aborigines.
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Special Article| February 01 1992
Kelly West Lecture 1991 Challenges in Diabetes Epidemiology—From West to the Rest
Address Correspondence and Reprint Requests to Paul Z. Zimmet, MD, PHD, International Diabetes Institute, 260 Kooyong Road, Caulfield South, 3162 Melbourne, Australia.
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Paul Z Zimmet; Kelly West Lecture 1991 Challenges in Diabetes Epidemiology—From West to the Rest. Diabetes Care 1 February 1992; 15 (2): 232–252. https://doi.org/10.2337/diacare.15.2.232
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