OBJECTIVE: The aim of this prospective study was to determine risk factor clusters predicting type 2 diabetes in subjects with and without family history of diabetes by applying factor analyses. RESEARCH DESIGN AND METHODS: The study population consisted of 309 siblings of diabetic (DM+) or nondiabetic (DM-) probands. Risk factors, including lipids, lipoproteins, blood pressure, and glucose tolerance status, were measured at the baseline study and 8 years later. RESULTS: Siblings in the DM+ group had a significantly higher risk of diabetes (odds ratio [OR] = 3.25; P = 0.002) than siblings in the DM- group. Altogether, factor analyses revealed four significant factors in both the DM+ and DM- groups (the percentage of cumulative variance explained 62-66%). Of these, factor 1 (percentage of variance, 27-29%) was characterized by high loadings for BMI, hypertension, glucose area, insulin area (the highest loading), and triglycerides in both the DM+ and DM- groups; therefore, factor 1 can be interpreted as a hyperinsulinemia factor. Also, other factors were essentially similar in both groups. Hyperinsulinemia factor was similarly associated with the risk of developing diabetes in the DM+ group (OR = 4.33, 95% CI 2.29-8.19; P < 0.001) and the DM- group (OR = 4.22, 95% CI 2.02-8.81; P < 0.001) in logistic regression analyses. CONCLUSIONS: Our results indicate that a cluster of cardiovascular risk factors around hyperinsulinemia is an important predictor of diabetes in 8-year follow-up independent of family history of diabetes.
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Abstract|
January 01 1999
Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes.
P Kekäläinen;
P Kekäläinen
Department of Medicine, Kuopio University Hospital, Finland. [email protected]
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H Sarlund;
H Sarlund
Department of Medicine, Kuopio University Hospital, Finland. [email protected]
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K Pyörälä;
K Pyörälä
Department of Medicine, Kuopio University Hospital, Finland. [email protected]
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M Laakso
M Laakso
Department of Medicine, Kuopio University Hospital, Finland. [email protected]
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Citation
P Kekäläinen, H Sarlund, K Pyörälä, M Laakso; Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes.. Diabetes Care 1 January 1999; 22 (1): 86–92. https://doi.org/10.2337/diacare.22.1.86
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