OBJECTIVE: To investigate whether serum levels of advanced glycation end products (AGEs) and the glycoxidation product Nepsilon-(carboxymethyl)lysine (CML) are increased in patients with type 2 diabetes compared with nondiabetic control subjects and whether levels of AGEs and/or CML differ in patients with type 2 diabetes with or without coronary heart disease (CHD). RESEARCH DESIGN AND METHODS: Serum levels of AGEs and CML were measured with an immunoassay in 32 men and 21 women aged 59.3+/-6.2 years (means +/- SD) with type 2 diabetes for 7.3 + 3.1 years and in 17 men and 17 women aged 56.2+/-4.2 years without diabetes. Of the patients with diabetes, 18 had CHD. RESULTS: The serum levels of AGEs and CML were significantly increased in patients with type 2 diabetes compared with nondiabetic control subjects (median [5th-95th percentile]: AGEs 7.4 [4.4-10.9] vs. 4.2 [1.6-6.4] U/ml, P < 0.0001; CML 15.6 [5.6-29.9] vs. 8.6 [4.4-25.9] U/ml, P < 0.0001). The median level of AGEs but not CML was significantly increased in patients with type 2 diabetes and CHD compared with patients without CHD (8.1 [6.4-10.9] vs. 7.1 [3.5-9.8] U/ml, P = 0.03). There were significant positive correlations between serum levels of AGEs and CML in both patients and control subjects. CONCLUSIONS: Levels of AGEs and CML were significantly increased in patients with type 2 diabetes compared with nondiabetic control subjects, and levels of AGEs but not CML were significantly higher in patients with type 2 diabetes and CHD than in patients without diabetes. These results may indicate a role for non-CML AGEs in the development of macrovascular disease in patients with type 2 diabetes.
Skip Nav Destination
Article navigation
Abstract|
September 01 1999
Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease.
B K Kilhovd;
B K Kilhovd
Aker Diabetes Research Centre, Department of Endocrinology, Aker University Hospital, Oslo, Norway. [email protected]
Search for other works by this author on:
T J Berg;
T J Berg
Aker Diabetes Research Centre, Department of Endocrinology, Aker University Hospital, Oslo, Norway. [email protected]
Search for other works by this author on:
K I Birkeland;
K I Birkeland
Aker Diabetes Research Centre, Department of Endocrinology, Aker University Hospital, Oslo, Norway. [email protected]
Search for other works by this author on:
P Thorsby;
P Thorsby
Aker Diabetes Research Centre, Department of Endocrinology, Aker University Hospital, Oslo, Norway. [email protected]
Search for other works by this author on:
K F Hanssen
K F Hanssen
Aker Diabetes Research Centre, Department of Endocrinology, Aker University Hospital, Oslo, Norway. [email protected]
Search for other works by this author on:
Citation
B K Kilhovd, T J Berg, K I Birkeland, P Thorsby, K F Hanssen; Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease.. Diabetes Care 1 September 1999; 22 (9): 1543–1548. https://doi.org/10.2337/diacare.22.9.1543
Download citation file: