Hanley AJG, McKeown-Eyssen G, Harris SB, Hegele RA, Wolever TMS, Kwan J, Connelly PW, Zinman B: Cross-sectional and prospective associations between proinsulin and cardiovascular disease risk factors in a population experiencing rapid cultural transition. Diabetes Care 24:1240–1247, 2001
In Table 3 of the above article, the partial r value for ApoB in column C was mistakenly changed from 0.23 to −0.23 during the composition process. The correct table appears here:
On page 975 of the same article, the authors would like to change “LDL cholesterol” in the first line of column 2 to “HDL cholesterol.” The correct sentence is as follows: “Our findings of significant independent associations of baseline concentrations of triglycerides, HDL cholesterol, and apoB with changes in proinsulin concentration over time are consistent with this pathophysiological mechanism.”
Metabolic characteristics and cardiovascular risk factors of subjects with normal and impaired glucose tolerance from the follow-up phase of the Sandy Lake Health and Diabetes Project (29 men; 66 women) and associations between baseline levels and changes over time in these variables*
| Variable . | Baseline values . | Change over 4-year follow-up period . | A†: Correlation between change in proinsulin and change in CVD variable . | B‡: Correlation between baseline proinsulin and change in CVD variable . | C†: Correlation between baseline CVD variable and change in proinsulin . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean . | SD . | Mean . | SD . | Partial r . | P . | Partial r . | P . | Partial r . | P . | |
| NGT/IGT/diabetes (n) | 41/54/0 | 54/17/24 | ||||||||
| Age at baseline (years) | 35.10 | 16.97 | — | — | ||||||
| Waist (cm) | 96.35 | 11.37 | 3.16 | 5.78 | ||||||
| C-peptide (pmol/l) | 831.72 | 438.46 | 299.25 | 485.26 | ||||||
| Proinsulin (pmol/l) | 17.06 | 11.60 | 3.66 | 18.40 | ||||||
| Cholesterol (mmol/l) | 4.70 | 0.85 | 0.09 | 1.38 | 0.31 | <0.01 | −0.11 | 0.33 | 0.10 | 0.39 |
| Triglycerides (mmol/l) | 1.61 | 0.75 | 0.29 | 2.20 | 0.25 | 0.02 | 0.03 | 0.79 | 0.23 | 0.04 |
| LDL cholesterol (mmol/l) | 2.78 | 0.68 | −0.08 | 0.54 | 0.24 | 0.04 | −0.12 | 0.31 | 0.18 | 0.10 |
| HDL cholesterol (mmol/l) | 1.19 | 0.26 | 0.02 | 0.20 | 0.11 | 0.32 | −0.03 | 0.81 | −0.30 | <0.01 |
| ApoB (g/l) | 1.16 | 0.27 | −0.05 | 0.19 | 0.26 | 0.02 | −0.19 | 0.09 | 0.23 | 0.04 |
| ApoAI (g/l) | 1.49 | 0.22 | −0.02 | 0.17 | 0.20 | 0.08 | −0.13 | 0.25 | −0.19 | 0.09 |
| Systolic BP (mmHg) | 121.00 | 15.48 | 4.68 | 13.10 | 0.13 | 0.23 | −0.09 | 0.43 | −0.14 | 0.23 |
| Diastolic BP (mmHg) | 68.74 | 11.08 | 4.74 | 11.51 | 0.11 | 0.34 | 0.07 | 0.52 | −0.02 | 0.83 |
| Variable . | Baseline values . | Change over 4-year follow-up period . | A†: Correlation between change in proinsulin and change in CVD variable . | B‡: Correlation between baseline proinsulin and change in CVD variable . | C†: Correlation between baseline CVD variable and change in proinsulin . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean . | SD . | Mean . | SD . | Partial r . | P . | Partial r . | P . | Partial r . | P . | |
| NGT/IGT/diabetes (n) | 41/54/0 | 54/17/24 | ||||||||
| Age at baseline (years) | 35.10 | 16.97 | — | — | ||||||
| Waist (cm) | 96.35 | 11.37 | 3.16 | 5.78 | ||||||
| C-peptide (pmol/l) | 831.72 | 438.46 | 299.25 | 485.26 | ||||||
| Proinsulin (pmol/l) | 17.06 | 11.60 | 3.66 | 18.40 | ||||||
| Cholesterol (mmol/l) | 4.70 | 0.85 | 0.09 | 1.38 | 0.31 | <0.01 | −0.11 | 0.33 | 0.10 | 0.39 |
| Triglycerides (mmol/l) | 1.61 | 0.75 | 0.29 | 2.20 | 0.25 | 0.02 | 0.03 | 0.79 | 0.23 | 0.04 |
| LDL cholesterol (mmol/l) | 2.78 | 0.68 | −0.08 | 0.54 | 0.24 | 0.04 | −0.12 | 0.31 | 0.18 | 0.10 |
| HDL cholesterol (mmol/l) | 1.19 | 0.26 | 0.02 | 0.20 | 0.11 | 0.32 | −0.03 | 0.81 | −0.30 | <0.01 |
| ApoB (g/l) | 1.16 | 0.27 | −0.05 | 0.19 | 0.26 | 0.02 | −0.19 | 0.09 | 0.23 | 0.04 |
| ApoAI (g/l) | 1.49 | 0.22 | −0.02 | 0.17 | 0.20 | 0.08 | −0.13 | 0.25 | −0.19 | 0.09 |
| Systolic BP (mmHg) | 121.00 | 15.48 | 4.68 | 13.10 | 0.13 | 0.23 | −0.09 | 0.43 | −0.14 | 0.23 |
| Diastolic BP (mmHg) | 68.74 | 11.08 | 4.74 | 11.51 | 0.11 | 0.34 | 0.07 | 0.52 | −0.02 | 0.83 |
Spearman correlation analysis, sample sizes vary slightly due to occasional missing values;
analyses adjusted for age, sex, change in C-peptide concentration, change in waist circumference, baseline and follow-up diabetes status, and baseline level of dependent and independent change variables;
analyses adjusted for age, sex, C-peptide concentration, change in waist circumference, baseline and follow-up diabetes status, and baseline level of dependent and independent change variables.
