Thirteen patients were instructed in a technique of self-management of insulin-dependent diabetes mellitus, using multiple home-monitored blood glucose determinations and multiple injections of regular insulin in conjunction with once-daily Ultra Lente insulin. Hemoglobin A1c and quantitative fluorescein fluorophotometry were used to assess blood glucose control and retinal permeability, respectively. In those patients achieving normal blood glucose control, retinal vascular leakage was statistically identical to that of a nondiabetic control population. In those patients less well controlled, retinal permeability did not differ statistically from values observed in a population of insulin-dependent diabetic patients under “standard” control. It is concluded that with “tight” control of blood sugar and normalized A1c hemoglobin, retinal permeability similarly is normalized.
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Original Articles|
January 01 1980
Effect of Blood Glucose Control on Retinal Vascular Permeability in Insulin-dependent Diabetes Mellitus
S J Bleicher;
S J Bleicher
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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T Y Lee;
T Y Lee
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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R Bernstein;
R Bernstein
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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L Schachter;
L Schachter
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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R Temes;
R Temes
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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T Krupin;
T Krupin
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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J Santiago;
J Santiago
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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B Becker;
B Becker
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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S R Waltman
S R Waltman
Department of Medicine, The Brooklyn Hospital, and the Department of Medicine, Downstate Medical Center, State University of New York, and the Departments of Ophthalmology and Pediatrics and Clinical Research Center, Washington University School of Medicine
St. Louis, Missouri, and St. Louis Children's Hospital
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Address reprint requests to S. J. Bleicher, M.D., Chairman, Department of Medicine, The Brooklyn Hospital, 121 DeKalb Avenue, Brooklyn, New York 11201.
Citation
S J Bleicher, T Y Lee, R Bernstein, L Schachter, R Temes, T Krupin, J Santiago, B Becker, S R Waltman; Effect of Blood Glucose Control on Retinal Vascular Permeability in Insulin-dependent Diabetes Mellitus. Diabetes Care 1 January 1980; 3 (1): 184–186. https://doi.org/10.2337/diacare.3.1.184
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