The Infusaid implantable infusion pump with a single delivery rate has maintained chronic intravenous heparin infusion in man for greater than 35 mo and for greater than 5 yr in the dog. Intra-arterial infuson of fluorodeoxyuridine has been maintained for greater than 8 mo in man. In a pilot study using a commercially available, transcutaneously controllable, magnetically activated valve for baseline superimposed bolus insulin infusion, the feasibility of maintaining near normal serum glucose in diabetic dogs was demonstrated. The effect of long-term intravenous cannulation was investigated; it was found that the intimal tissues of the vena cava surrounding the cannulae were largely unaltered and microemboli could not be detected in the lungs of the animals studied. Cannula plugging, which occurred on several occasions due to thrombus formation in the final centimeter of the cannula, has been solved by changes in pump design and refilling procedures. The problem of insulin precipitation in flow passages of the pump remains unsolved, but there are indications that substances entering the cannula from the blood may be involved. A new pump design for modulated insulin infusion is described.
Skip Nav Destination
Article navigation
Proceedings of the Kroc Foundation International Conference|
March 01 1980
A Totally Implantable Drug Infusion Defice: Laboratory and Clinical Experience Using a Model with Single Flow Rate and New Design for Modulated Insulin Infusion
Henry Buchwald;
Henry Buchwald
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Thomas D Rohde;
Thomas D Rohde
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Frank D Dorman;
Frank D Dorman
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
James G Skakoon;
James G Skakoon
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Bruce D Wigness;
Bruce D Wigness
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Frank R Prosl;
Frank R Prosl
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Elton M Tucker;
Elton M Tucker
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Tucker G Rublein;
Tucker G Rublein
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Perry J Blackshear;
Perry J Blackshear
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Richard L Varco
Richard L Varco
departments of surgery and mechanical engineering of the University of Minnesota
Minneapolis
; the Infusaid Division of the Metal Bellows Corporation
Sharon, Massachusetts
; and the endocrine unit of Massachusetts General Hospital
Boston
Search for other works by this author on:
Address reprint requests to Henry Buchwald, Department of Surgery, Box 290 Mayo, University of Minnesota Hospitals, Minneapolis, Minnesota 55455.
Citation
Henry Buchwald, Thomas D Rohde, Frank D Dorman, James G Skakoon, Bruce D Wigness, Frank R Prosl, Elton M Tucker, Tucker G Rublein, Perry J Blackshear, Richard L Varco; A Totally Implantable Drug Infusion Defice: Laboratory and Clinical Experience Using a Model with Single Flow Rate and New Design for Modulated Insulin Infusion. Diabetes Care 1 March 1980; 3 (2): 351–358. https://doi.org/10.2337/diacare.3.2.351
Download citation file:
