To test whether the beneficial effects of coffee consumption in metabolism might be explained by changes in circulating levels of adiponectin, we evaluated self-reported habitual coffee and tea consumption and caffeine intake as predictors of plasma adiponectin concentrations among 982 diabetic and 1,058 nondiabetic women without cardiovascular disease from the Nurses' Health Study. Women with and without diabetes who drank ≥4 cups of coffee per day had significantly higher adiponectin concentrations than those who didn't drink coffee regularly (7.7 vs. 6.1 μg/ml, respectively, in diabetic women, P = 0.004; 15.0 vs. 13.2 μg/ml in nondiabetic women, P = 0.04). Similar associations were observed for caffeine intake. We confirm previously reported inverse associations of coffee consumption with inflammatory markers, C-reactive protein, and tumor necrosis factor-α receptor II. Adjustment for adiponectin did not weaken these associations, and adjustment for inflammatory markers did not attenuate the association between coffee consumption and adiponectin concentrations. High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations.

We studied 982 women with type 2 diabetes and 1,058 nondiabetic women from the Nurses' Health Study (which provided measures of plasma adiponectin concentration and data on usual coffee consumption) who were free of coronary heart disease, myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, and stroke at blood draw in 1990. Disease status was confirmed as previously reported (1).

Data on exposures, outcomes, and covariates were collected from questionnaires, as previously reported (14). Food intake data in the Nurses' Health Study have been assessed using a semiquantitative food frequency questionnaire (SFFQ) (4), the validity and reliability of which have been previously described (57), with high correlations between responses to the SFFQ and four 1-week dietary records for coffee (r = 0.78), tea (r = 0.94), and caffeinated sodas (r = 0.85) (5). We also assessed total caffeine intake (8). Averages of coffee, tea, and caffeine intake from the 1984, 1986, and 1990 SFFQs were calculated to account for long-term dietary exposure and reduce within-person variability. Blood samples were taken in 1989 or 1990, and adiponectin was assayed (2,9).

Comparisons of descriptive measures were conducted using ANOVA for continuous variables and appropriate χ2 tests for categorical variables across groups of caffeine-containing coffee consumers. Associations between beverage consumption and plasma adiponectin concentrations were evaluated using simple linear regression models for crude analysis and multiple linear regressions with logarithmic transformation of hormone values to achieve normal distribution. We adjusted for potential confounders in multivariate analyses. Tests for interaction were conducted using linear regression with multiplicative interaction terms. Analyses were conducted using SAS (version 9.1 for UNIX; SAS Institute, Cary, NC). P values are two sided.

Both diabetic and nondiabetic women who drank coffee on a daily basis had significantly higher total energy and caffeine intake and were more likely to be current smokers and less likely to be hypertensive or use thiazide diuretics. Diabetic women in the highest coffee consumption group also had a significantly lower BMI, higher alcohol intake, and were more likely to report a family history of diabetes, whereas nondiabetic women in the highest coffee group had significantly higher weekly physical activity and were more likely to be employed full-time. (Table 1)

Diabetic women who consumed four or more cups of caffeine-containing coffee per day had significantly higher adiponectin concentrations than those who drank lower amounts, even after full adjustment (Table 1). Nondiabetic women in the same group had higher adiponectin concentrations as well, with significant differences among coffee groups after adjustment. Also presented are analyses by quartile of caffeine intake, which were very similar to results for caffeine-containing coffee. We found no evidence of interaction by age, obesity, alcohol consumption, or smoking status on the association of caffeine-containing coffee with adiponectin. Additional adjustment for the dietary factors of glycemic load, dietary fiber intake, and Mediterranean diet pattern adherence did not significantly change the results.

No association between consumption of decaffeinated coffee and adiponectin concentration was found in either group. Intake of two or more cups of tea per day tended to be associated with higher adiponectin concentrations among diabetic women, and the association remained marginal after adjusting for lifestyle and medical history covariates (P = 0.07) (data not shown).

We confirm previously reported inverse associations of coffee consumption with inflammatory markers (4) among diabetic women, specifically C-reactive protein (P = 0.001) and tumor necrosis factor-α receptor II (P = 0.03). Adjustment for adiponectin did not weaken these associations, and adjustment for inflammatory markers did not attenuate the association between coffee consumption and adiponectin concentrations (P <0.05 for all).

Regular consumption of coffee may have beneficial effects including decreased insulin resistance, decreased incidence of type 2 diabetes, and lower levels of markers of inflammation; however, the exact underlying mechanisms are not completely understood (4,8,1017). Our study suggests that favorable metabolic effects of caffeine-containing coffee may partly operate through associations with serum adiponectin concentrations. We found that habitual consumption of four or more cups of caffeine-containing coffee per day was associated with ∼20% higher serum adiponectin concentrations than those associated with habitual consumption of less than four cups of coffee daily, indicating that increased adiponectin may play a role in the beneficial effects of coffee on insulin sensitivity. Our data are consistent with several previous prospective studies that demonstrated a decreased risk of type 2 diabetes with higher coffee consumption, with observed benefits starting at three to six cups per day (8,12,15). Our data extend recent findings that coffee consumption is associated with lower levels of E-selectin and C-reactive protein among women with diabetes (4) and suggest that coffee and/or caffeine may have unique effects on inflammatory processes, insulin sensitivity, and metabolism. Decaffeinated coffee and tea consumption was not associated with high adiponectin concentrations, but only a small number of women consumed four or less cups of decaffeinated coffee per day.

In addition to genetic factors, several modifiable lifestyle factors, including diet (2,18) and increased physical activity (19), may at least partially determine circulating levels of the endogenous insulin sensitizer adiponectin (2023). However, unlike high levels of physical activity and maintaining a healthy diet, which commonly cluster with an overall healthy lifestyle, coffee consumption has been linked to poorer health habits, such as cigarette smoking and physical inactivity (24).

Phenolic compounds found in coffee may slow intestinal glucose absorption postprandially and improve GLP-1 secretion and glucose metabolism (25,26), and coffee may have antioxidant activities (27). Mechanistic and interventional studies are necessary to determine whether the association between coffee intake and high adiponectin concentrations is causal and what bioactive components might underlie this relationship.

Table 1—

Baseline characteristics and adiponectin levels of diabetic and nondiabetic subjects categorized into quartiles of caffeine-containing coffee (cups) or caffeine (milligrams) consumption

VariableCaffeine-containing coffee consumption (cups)
P
<1 per week1–6 per week1–3 per day≥4 per day
Baseline characteristics      
    Diabetic subjects      
        n 269 224 387 102  
        Adiponectin (μg/ml) 5.7 (3.4–8.6) 5.7 (3.6–8.5) 5.2 (3.5–8.7) 6.6 (4.2–12.1) 0.002 
        Demographic      
            Age (years) 58.6 ± 6.7 59.2 ± 6.7 59 ± 6.7 58.1 ± 5.9 0.44 
            BMI (kg/m230.4 ± 6.5 30.8 ± 6.4 29.5 ± 5.9 28.5 ± 6.8 0.005 
            Waist-to-hip ratio 0.85 ± 0.13 0.84 ± 0.07 0.83 ± 0.07 0.83 ± 0.1 0.41 
            Physical activity (METs/week) 12.7 ± 17.6 12.4 ± 14.8 11.1 ± 14.4 10.2 ± 14 0.39 
            Total energy intake (kcal) 1713 ± 496 1762 ± 465 1833 ± 438 1842 ± 495 0.006 
            Alcohol (g/day) 2.2 ± 7.3 2.7 ± 5.8 4.7 ± 9.0 4.4 ± 9.1 0.0002 
            Caffeine (mg/day) 83 ± 69 185 ± 97 336 ± 114 630 ± 141 <0.0001 
            Current smoker 19 (7) 21 (9) 58 (15) 38 (34) <0.0001 
            Married 221 (87) 175 (81) 294 (80) 86 (77) 0.07 
            Bachelor's degree or higher 66 (26) 54 (25) 82 (22) 26 (23) 0.71 
            Full-time employment 64 (25) 58 (27) 103 (28) 33 (29) 0.82 
        Medical history      
            Hypertension 127 (47) 89 (40) 157 (41) 38 (33) 0.06 
            Hypercholesterolemia 113 (42) 95 (42) 151 (40) 37 (32) 0.30 
            Family history of diabetes 124 (46) 104 (46) 208 (55) 66 (58) 0.03 
    Nondiabetic Subjects      
        n 276 232 444 106  
        Adiponectin (μg/ml) 18.3 (12.6–23.6) 17.8 (13.3–22.7) 17.4 (12.8–22.5) 20.1 (15.1–23.1) 0.06 
        Demographic      
            Age (years) 56.6 ± 7.4 57.1 ± 6.7 56.2 ± 6.8 55.0 ± 6.4 0.06 
            BMI (kg/m225.7 ± 5.9 26.6 ± 6.0 26.4 ± 6.1 25.8 ± 5.7 0.32 
            Waist-to-hip ratio 0.77 ± 0.06 0.79 ± 0.08 0.77 ± 0.06 0.77 ± 0.06 0.11 
            Physical activity (METs/week) 13.2 ± 16.1 15.7 ± 18.4 12.9 ± 14.4 19.7 ± 35.2 0.006 
            Total energy intake (kcal) 1746 ± 435 1739 ± 434 1750 ± 455 1897 ± 482 0.01 
            Alcohol (g/day) 5.1 ± 9.2 6.2 ± 9.0 6.9 ± 9.7 6.2 ± 9.6 0.09 
            Caffeine (mg/day) 90 ± 84 200 ± 99 354 ± 108 645 ± 142 <0.0001 
            Current smoker 17 (6) 24 (10) 55 (12) 26 (25) <0.0001 
            Married 223 (82) 183 (81) 375 (86) 80 (82) 0.30 
            Bachelor's degree or higher 94 (35) 70 (31) 140 (32) 27 (28) 0.63 
            Full-time employment 88 (33) 60 (27) 163 (37) 43 (44) 0.007 
        Medical history      
            Hypertension 31 (11) 49 (21) 84 (19) 19 (18) 0.02 
            Hypercholesterolemia 75 (27) 79 (34) 127 (29) 27 (25) 0.26 
            Family history of diabetes 56 (20) 44 (19) 101 (23) 17 (16) 0.40 
Adiponectin (μg/ml)      
    Diabetic subjects      
        n 269 224 387 102  
        Unadjusted 5.7 (1.0–41.8) 5.8 (1.2–35.9) 5.5 (1.1–30.2) 7.3 (1.3–31.7) 0.002 
        Model 1 5.4 5.5 5.1 6.5 0.01 
        Model 2 5.0 5.2 4.8 6.4 0.002 
        Model 3 6.1 6.3 5.9 7.7 0.004 
    Nondiabetic subjects      
        n 276 232 444 106  
        Unadjusted 16.9 (12.6–23.6) 16.8 (13.3–22.7) 16.5 (23.8–22.5) 19.0 (15.1–23.14) 0.06 
        Model 1 14.5 14.7 14.3 16.3 0.06 
        Model 2 14.0 13.9 13.6 15.9 0.04 
        Model 3 13.2 13.2 12.9 15.0 0.04 
VariableCaffeine-containing coffee consumption (cups)
P
<1 per week1–6 per week1–3 per day≥4 per day
Baseline characteristics      
    Diabetic subjects      
        n 269 224 387 102  
        Adiponectin (μg/ml) 5.7 (3.4–8.6) 5.7 (3.6–8.5) 5.2 (3.5–8.7) 6.6 (4.2–12.1) 0.002 
        Demographic      
            Age (years) 58.6 ± 6.7 59.2 ± 6.7 59 ± 6.7 58.1 ± 5.9 0.44 
            BMI (kg/m230.4 ± 6.5 30.8 ± 6.4 29.5 ± 5.9 28.5 ± 6.8 0.005 
            Waist-to-hip ratio 0.85 ± 0.13 0.84 ± 0.07 0.83 ± 0.07 0.83 ± 0.1 0.41 
            Physical activity (METs/week) 12.7 ± 17.6 12.4 ± 14.8 11.1 ± 14.4 10.2 ± 14 0.39 
            Total energy intake (kcal) 1713 ± 496 1762 ± 465 1833 ± 438 1842 ± 495 0.006 
            Alcohol (g/day) 2.2 ± 7.3 2.7 ± 5.8 4.7 ± 9.0 4.4 ± 9.1 0.0002 
            Caffeine (mg/day) 83 ± 69 185 ± 97 336 ± 114 630 ± 141 <0.0001 
            Current smoker 19 (7) 21 (9) 58 (15) 38 (34) <0.0001 
            Married 221 (87) 175 (81) 294 (80) 86 (77) 0.07 
            Bachelor's degree or higher 66 (26) 54 (25) 82 (22) 26 (23) 0.71 
            Full-time employment 64 (25) 58 (27) 103 (28) 33 (29) 0.82 
        Medical history      
            Hypertension 127 (47) 89 (40) 157 (41) 38 (33) 0.06 
            Hypercholesterolemia 113 (42) 95 (42) 151 (40) 37 (32) 0.30 
            Family history of diabetes 124 (46) 104 (46) 208 (55) 66 (58) 0.03 
    Nondiabetic Subjects      
        n 276 232 444 106  
        Adiponectin (μg/ml) 18.3 (12.6–23.6) 17.8 (13.3–22.7) 17.4 (12.8–22.5) 20.1 (15.1–23.1) 0.06 
        Demographic      
            Age (years) 56.6 ± 7.4 57.1 ± 6.7 56.2 ± 6.8 55.0 ± 6.4 0.06 
            BMI (kg/m225.7 ± 5.9 26.6 ± 6.0 26.4 ± 6.1 25.8 ± 5.7 0.32 
            Waist-to-hip ratio 0.77 ± 0.06 0.79 ± 0.08 0.77 ± 0.06 0.77 ± 0.06 0.11 
            Physical activity (METs/week) 13.2 ± 16.1 15.7 ± 18.4 12.9 ± 14.4 19.7 ± 35.2 0.006 
            Total energy intake (kcal) 1746 ± 435 1739 ± 434 1750 ± 455 1897 ± 482 0.01 
            Alcohol (g/day) 5.1 ± 9.2 6.2 ± 9.0 6.9 ± 9.7 6.2 ± 9.6 0.09 
            Caffeine (mg/day) 90 ± 84 200 ± 99 354 ± 108 645 ± 142 <0.0001 
            Current smoker 17 (6) 24 (10) 55 (12) 26 (25) <0.0001 
            Married 223 (82) 183 (81) 375 (86) 80 (82) 0.30 
            Bachelor's degree or higher 94 (35) 70 (31) 140 (32) 27 (28) 0.63 
            Full-time employment 88 (33) 60 (27) 163 (37) 43 (44) 0.007 
        Medical history      
            Hypertension 31 (11) 49 (21) 84 (19) 19 (18) 0.02 
            Hypercholesterolemia 75 (27) 79 (34) 127 (29) 27 (25) 0.26 
            Family history of diabetes 56 (20) 44 (19) 101 (23) 17 (16) 0.40 
Adiponectin (μg/ml)      
    Diabetic subjects      
        n 269 224 387 102  
        Unadjusted 5.7 (1.0–41.8) 5.8 (1.2–35.9) 5.5 (1.1–30.2) 7.3 (1.3–31.7) 0.002 
        Model 1 5.4 5.5 5.1 6.5 0.01 
        Model 2 5.0 5.2 4.8 6.4 0.002 
        Model 3 6.1 6.3 5.9 7.7 0.004 
    Nondiabetic subjects      
        n 276 232 444 106  
        Unadjusted 16.9 (12.6–23.6) 16.8 (13.3–22.7) 16.5 (23.8–22.5) 19.0 (15.1–23.14) 0.06 
        Model 1 14.5 14.7 14.3 16.3 0.06 
        Model 2 14.0 13.9 13.6 15.9 0.04 
        Model 3 13.2 13.2 12.9 15.0 0.04 
Caffeine Q1Caffeine Q2Caffeine Q3Caffeine Q4P
Diabetic subjects      
    n 243 244 245 245  
    Unadjusted 5.6 (3.5–8.0) 5.4 (6.4–8.2) 5.6 (3.5–8.9) 6.4 (3.8–10.8) 0.02 
    Model 1 4.6 4.6 4.6 5.6 0.04 
    Model 2 4.8 4.8 4.8 5.8 0.003 
    Model 3 6.0 5.8 5.9 7.0 0.004 
Nondiabetic subjects      
    n 255 247 284 272  
    Unadjusted 16.9 (12.7–24.2) 16.6 (12.9–22.2) 16.4 (12.7–22.9) 17.6 (13.9–23.4) 0.36 
    Model 1 14.6 14.3 14.3 15.3 0.29 
    Model 2 14.3 13.6 13.6 14.7 0.17 
    Model 3 13.5 12.9 12.9 13.9 0.18 
Caffeine Q1Caffeine Q2Caffeine Q3Caffeine Q4P
Diabetic subjects      
    n 243 244 245 245  
    Unadjusted 5.6 (3.5–8.0) 5.4 (6.4–8.2) 5.6 (3.5–8.9) 6.4 (3.8–10.8) 0.02 
    Model 1 4.6 4.6 4.6 5.6 0.04 
    Model 2 4.8 4.8 4.8 5.8 0.003 
    Model 3 6.0 5.8 5.9 7.0 0.004 
Nondiabetic subjects      
    n 255 247 284 272  
    Unadjusted 16.9 (12.7–24.2) 16.6 (12.9–22.2) 16.4 (12.7–22.9) 17.6 (13.9–23.4) 0.36 
    Model 1 14.6 14.3 14.3 15.3 0.29 
    Model 2 14.3 13.6 13.6 14.7 0.17 
    Model 3 13.5 12.9 12.9 13.9 0.18 

Data are median (interquartile range), means ± SD, and n (%) for baseline characteristics and modeled median (interquartile range) and geometric mean % for adiponectin data. P values determined by ANOVA for continuous measures with logarithmic transformation of biomarkers and χ2 tests for categorical variables. Model 1: adjusted for age and BMI; model 2: adjusted additionally for physical activity (METs/week), total energy intake, alcohol intake (g/day), and smoking status (never, former, or current); model 3: adjusted additionally for hypertension, hypercholesterolemia, A1C, family history of diabetes, aspirin, postmenopausal hormone use, use of ACE inhibitors and other blood pressure medication, and oral diabetes medication use (A1C, insulin and oral diabetes medication not adjusted for in healthy women). Dichotomous (yes/no) variables and continuous measures categorized into quintiles and modeled using indicator variables. P values for differences between categories determined from multivariate linear regression models. For women with diabetes, data were missing for caffeine intake (n = 5), so the numbers will be less than the total sample size (n = 982). Q1, quartile 1 (0–100 mg); Q2, quartile 2 (101–237 mg); Q3, quartile 3 (237–378 mg); Q4, quartile 4 (379–967 mg).

This work was funded by grants HL65582, HL60712, HL34594, DK58785, and DK58845 from the National Institutes of Health. F.B.H. is a recipient of the American Heart Association Established Investigator Award. C.S.M. is supported by a discretionary grant from the Beth Israel Deaconess Medical Center, and a grant-in-aid by Tanita Corporation and is a recipient of the Bessel Award from the Alexander von Humboldt Foundation.

1.
Mantzoros CS, Li T, Manson JE, Meigs JB, Hu FB: Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes.
J Clin Endocrinol Metab
90
:
4542
–4548,
2005
2.
Mantzoros CS, Williams CJ, Manson JE, Meigs JB, Hu FB: Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women.
Am J Clin Nutr
84
:
328
–335,
2006
3.
Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE: Adiposity as compared with physical activity in predicting mortality among women.
N Engl J Med
351
:
2694
–2703,
2004
4.
Lopez-Garcia E, van Dam RM, Qi L, Hu FB: Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women.
Am J Clin Nutr
84
:
888
–893,
2006
5.
Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, Willett WC: Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption.
Int J Epidemiol
18
:
858
–867,
1989
6.
Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE: Reproducibility and validity of a semiquantitative food frequency questionnaire.
Am J Epidemiol
122
:
51
–65,
1985
7.
Willett WC, Sampson L, Browne ML, Stampfer MJ, Rosner B, Hennekens CH, Speizer FE: The use of a self-administered questionnaire to assess diet four years in the past.
Am J Epidemiol
127
:
188
–199,
1988
8.
van Dam RM, Willett WC, Manson JE, Hu FB: Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women.
Diabetes Care
29
:
398
–403,
2006
9.
Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS: Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers.
Clin Endocrinol (Oxf)
61
:
332
–338,
2004
10.
Agardh EE, Carlsson S, Ahlbom A, Efendic S, Grill V, Hammar N, Hilding A, Ostenson CG: Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women.
J Intern Med
255
:
645
–652,
2004
11.
Carlsson S, Hammar N, Grill V, Kaprio J: Coffee consumption and risk of type 2 diabetes in Finnish twins.
Int J Epidemiol
33
:
616
–617,
2004
12.
Pereira MA, Parker ED, Folsom AR: Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women.
Arch Intern Med
166
:
1311
–1316,
2006
13.
Rosengren A, Dotevall A, Wilhelmsen L, Thelle D, Johansson S: Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study.
J Intern Med
255
:
89
–95,
2004
14.
Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ, Hu FB: Coffee consumption and risk for type 2 diabetes mellitus.
Ann Intern Med
140
:
1
–8,
2004
15.
Tuomilehto J, Hu G, Bidel S, Lindstrom J, Jousilahti P: Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women.
JAMA
291
:
1213
–1219,
2004
16.
van Dam RM, Feskens EJ: Coffee consumption and risk of type 2 diabetes mellitus.
Lancet
360
:
1477
–1478,
2002
17.
Yamaji T, Mizoue T, Tabata S, Ogawa S, Yamaguchi K, Shimizu E, Mineshita M, Kono S: Coffee consumption and glucose tolerance status in middle-aged Japanese men.
Diabetologia
47
:
2145
–2151,
2004
18.
Qi L, Meigs JB, Liu S, Manson JE, Mantzoros C, Hu FB: Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes.
Diabetes Care
29
:
1501
–1505,
2006
19.
Bluher M, Bullen JW, Jr, Lee JH, Kralisch S, Fasshauer M, Kloting N, Niebauer J, Schon MR, Williams CJ, Mantzoros CS: Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.
J Clin Endocrinol Metab
91
:
2310
–2316,
2006
20.
Bouskila M, Pajvani UB, Scherer PE: Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity?
Int J Obes (Lond)
29 (Suppl 1)
:
S17
–S23,
2005
21.
Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors.
Endocr Rev
26
:
439
–451,
2005
22.
Stefan N, Stumvoll M: Adiponectin—its role in metabolism and beyond.
Horm Metab Res
34
:
469
–474,
2002
23.
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nat Med
8
:
1288
–1295,
2002
24.
Higdon JV, Frei B: Coffee and health: a review of recent human research.
Crit Rev Food Sci Nutr
46
:
101
–123,
2006
25.
Arion WJ, Canfield WK, Ramos FC, Schindler PW, Burger HJ, Hemmerle H, Schubert G, Below P, Herling AW: Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase.
Arch Biochem Biophys
339
:
315
–322,
1997
26.
Johnston KL, Clifford MN, Morgan LM: Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine.
Am J Clin Nutr
78
:
728
–733,
2003
27.
Richelle M, Tavazzi I, Offord E: Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving.
J Agric Food Chem
49
:
3438
–3442,
2001

Published ahead of print at http://care.diabetesjournals.org on 10 December 2007. DOI: 10.2337/dc07-1952.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.