The Diabetes Prevention Program Research Group. The 10-year cost-effectiveness of lifestyle intervention or metformin for diabetes prevention: an intent-to-treat analysis of the DPP/DPPOS. Diabetes Care 2012;35:723–730

In the article listed above, an error was discovered in the calculation of the direct medical costs of inpatient care outside the DPP/DPPOS. The costs of inpatient care were underestimated across the lifestyle, metformin, and placebo treatment groups due to delayed reporting of hospitalizations by some clinical sites and the authors’ failure to count hospitalizations when the study year in which they occurred was initially unknown. The authors have now corrected this problem. In addition, they have updated the analyses to include the complete resource utilization and cost data that are newly available through 10 years of combined DPP/DPPOS follow-up. The authors have also classified participants who were diagnosed with diabetes at mid-year study visits as having diabetes during that year.

Tables 1 and 2 show the corrected and updated undiscounted annual direct medical costs of the interventions and direct medical costs of care outside the DPP/DPPOS per participant. Table 3 shows the corrected differences in costs and quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios adjusted for survival. The revised results do not change the conclusions of the article. Over 10 years, the total per capita cost of the lifestyle intervention, that is, the average cost of the lifestyle intervention plus the average cost of medical care received by a lifestyle participant outside the DPP/DPPOS, was greater than the total per capita cost of the placebo intervention. This was true from all three study perspectives (health system, modified societal, and societal perspectives). Over 10 years, the lifestyle intervention also resulted in more total QALYs than the placebo intervention. Over 10 years, metformin had a slightly lower total per capita cost than placebo and yielded approximately the same number of QALYs as placebo. From a health system perspective, after adjusting for survival, and with both costs and health outcomes discounted at 3% per year, lifestyle cost was approximately $13,000 per QALY gained compared with placebo. Metformin was cost-saving compared with placebo. Compared with metformin, lifestyle cost more but produced better health outcomes with a cost-effectiveness ratio of approximately $15,000 per QALY gained. DPP group lifestyle was estimated to be slightly more costly but much more effective than placebo with a cost-effectiveness ratio of $1,000 per QALY gained.

These updated analyses demonstrate that over 10 years, lifestyle, when compared with placebo, is cost-effective and metformin is marginally cost-saving. Lifestyle is also cost-effective when compared with metformin. If a DPP group lifestyle intervention could be delivered at one-third lower cost than the DPP lifestyle intervention and achieve the same outcomes, it would be extremely cost-effective compared with placebo.

The corrected Tables 13 and Figure 1 appear below. Supplementary Tables 1–4 have been revised and are available in Supplementary Data online (http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc11-1468/-/DC1). The entire article including abstract, text, figure, and tables has been corrected online.

Table 1

Undiscounted, per capita, direct medical costs of the DPP/DPPOS interventions by intervention group and study year ($)*

Undiscounted, per capita, direct medical costs of the DPP/DPPOS interventions by intervention group and study year ($)*
Undiscounted, per capita, direct medical costs of the DPP/DPPOS interventions by intervention group and study year ($)*
Table 2

Undiscounted, per capita, direct medical costs of care outside the DPP/DPPOS by intervention group and study year, and distribution of undiscounted, per capita, 10-year, direct medical costs of care outside the DPP/DPPOS by intervention group and type ($)

Undiscounted, per capita, direct medical costs of care outside the DPP/DPPOS by intervention group and study year, and distribution of undiscounted, per capita, 10-year, direct medical costs of care outside the DPP/DPPOS by intervention group and type ($)
Undiscounted, per capita, direct medical costs of care outside the DPP/DPPOS by intervention group and study year, and distribution of undiscounted, per capita, 10-year, direct medical costs of care outside the DPP/DPPOS by intervention group and type ($)
Table 3

Differences in total costs and QALYs and incremental cost-effectiveness ratios* for lifestyle and metformin versus placebo and lifestyle versus metformin over 10 years from three alternative perspectives

Differences in total costs and QALYs and incremental cost-effectiveness ratios* for lifestyle and metformin versus placebo and lifestyle versus metformin over 10 years from three alternative perspectives
Differences in total costs and QALYs and incremental cost-effectiveness ratios* for lifestyle and metformin versus placebo and lifestyle versus metformin over 10 years from three alternative perspectives
Figure 1

A: Cumulative, undiscounted, per participant, direct medical costs of the DPP/DPPOS interventions by intervention group and study year. B: Cumulative, undiscounted, per participant, direct medical costs of medical care received outside the DPP/DPPOS by intervention group and study year. C: Cumulative, undiscounted, per participant, total direct medical costs of the DPP/DPPOS interventions and medical care received outside the DPP/DPPOS by intervention group and study year. D: Cumulative, undiscounted, per participant, total Quality of Well-Being Index by intervention group and year.

Figure 1

A: Cumulative, undiscounted, per participant, direct medical costs of the DPP/DPPOS interventions by intervention group and study year. B: Cumulative, undiscounted, per participant, direct medical costs of medical care received outside the DPP/DPPOS by intervention group and study year. C: Cumulative, undiscounted, per participant, total direct medical costs of the DPP/DPPOS interventions and medical care received outside the DPP/DPPOS by intervention group and study year. D: Cumulative, undiscounted, per participant, total Quality of Well-Being Index by intervention group and year.

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