Risks of Psychiatric Disorders and Suicide Attempts in Children and Adolescents With Type 1 Diabetes: A Population-Based Cohort Study Free

For decades, children with type 1 diabetes have been assumed to be at risk for psychiatric disorders (1). Much of this assertion is based on clinical observations (2–4). Also, large epidemiological studies have shown increased risks of psychiatric disorders in other chronic pediatric diseases (5,6), and it is reasonable to assume that such associations may also be present for type 1 diabetes. Another theory has been that the threat of serious complications and strict treatment regimen put high demand on children and their caregivers, which in turn increase the risk for psychiatric disorders (7). Nevertheless, the psychiatric disorders among children with type 1 diabetes have not yet been properly tested in large samples. Previous studies on the effect of childhood type 1 diabetes on the development of psychopathology have only used small and highly selected clinical samples (7–12). These studies have produced equivocal and inconclusive findings. For example, three studies reported a two- to threefold increased rate of psychiatric disorders in children with type 1 diabetes compared with their peers (7–9), whereas other reports showed that there is no association (11,12).

Exploring the association between type 1 diabetes and risk of psychiatric disorders is of high importance for parents, pediatric endocrinologists, and researchers and has implications for recommendations on care of children with type 1 diabetes. For example, are potential associations higher in connection with the onset of type 1 diabetes? Has the magnitude of the associations changed with changing treatment practice of type 1 diabetes during the last decades?

The main aim of our study was to assess the risk of psychiatric disorders in children with type 1 diabetes. To overcome limitations of previous studies, we used Swedish registers with high coverage and prospectively collected information to study the risk of psychiatric disorders in a large, nationwide, population-based data set. We hypothesized that children would be especially vulnerable to development of psychiatric disorders within a 6-month period after diagnosis of type 1 diabetes. We also expected that secular changes in diabetes care and diagnostic practice in child psychiatry would influence the prevalence and risk of psychiatric disorders among children with type 1 diabetes. In addition, to investigate a possible mechanism behind the association between type 1 diabetes and psychiatric disorders, we performed complementary analyses on the risk of psychiatric disorders among healthy siblings of probands. This enabled us to test the hypothesis that the association between psychiatric disorders and type 1 diabetes is caused by familial factors, where high risk of psychiatric disorders among healthy siblings of children with type 1 diabetes would support a familial effect.

We used data from the Swedish Pediatric Diabetes Quality Registry (SWEDIABKIDS), Swedish National Diabetes Register (NDR), and the Swedish National Patient Register (NPR) to identify patients (probands) born in Sweden from 1964 onward with onset of type 1 diabetes before 18 years of age. Since 2000, the SWEDIABKIDS has been recording data from all Swedish pediatric diabetes centers reaching 99% national coverage in 2007 (13). In 1996, the NDR was initiated as a quality measure in diabetes care at a national level (14). Annual reports on patients treated for diabetes are delivered nationwide by hospitals as well as outpatient and primary care health centers. NDR provides information on type of diabetes, date of onset, and insulin regimen. The NPR contains data on somatic and psychiatric inpatient health care since 1973 and outpatient care since 2001 (15).

For every patient with childhood-onset type 1 diabetes, we randomly selected 100 control subjects (unexposed individuals) from the Total Population Register. Probands and unexposed individuals were matched by sex, year, and county of birth. The unexposed individuals were required to be born in Sweden after 1972, not have diabetes of any type before the age of 18 years, and be alive and living in Sweden at the time of diagnosis of diabetes of the matched proband (description of study design in Supplementary Fig. 1). Probands were divided into cohorts born 1973–1986, 1987–1996, and 1997–2009 based on the time of diagnosis of type 1 diabetes. These cohorts were chosen because they coincide with changes in ICD classification in Sweden (introduction of ICD-9 was 1987 and ICD-10 was in 1997). To investigate the mechanism behind the association between type 1 diabetes and childhood psychiatric disorders, we also studied psychiatric outcomes in full siblings of the patients with type 1 diabetes (siblings of probands). Biological relationship with patients with type 1 diabetes was established through the Multi-Generation Register, which links children to their biological parents (16). Healthy siblings of probands were defined as children of the same parents without a diagnosis of diabetes of any type before the age of 18 years. Similar to the comparisons between probands and unexposed, 100 healthy control sibling pairs (unexposed siblings) were randomly selected and matched to each case-sibling pair by sex, year, and county of birth of both siblings. Both subjects in the relative control pair were required to be free of a diabetes diagnosis of any type prior to the age of 18 years (Supplementary Fig. 2).

Type 1 diabetes was defined as having such a diagnosis in the SWEDIABKIDS or NDR or an ICD code in the NPR (ICD-8: 250.00–250.09; ICD-9: 250A–250X; ICD-10: E10). ICD-8 and -9 do not distinguish between type 1 and type 2 diabetes, but in our age range (≤18 years) these codes identify type 1 diabetes with high positive predictive value, as type 2 diabetes is rather infrequent in the Swedish population up to 18 years of age (17). We excluded 70 children who were later rediagnosed as having monogenic diabetes (not type 1 diabetes). Furthermore, 153 patients were diagnosed with type 1 diabetes outside Sweden and therefore excluded from further analysis owing to uncertain date of diagnosis and psychiatric morbidity prior to diabetes.

Outcome variables related to psychiatric disorders were obtained from the NPR. The variables were defined in accordance with ICD classifications: 1) any psychiatric disorders (ICD-8 codes 290–315, ICD-9 codes 290–319, and ICD-10 codes F00-F99), 2) suicide attempt (ICD-8/ICD-9 codes E950-E959 or E980-E989 and ICD-10 codes X60–X84 or Y10–Y34), 3) psychotic disorders (ICD-8 codes 295 and 297–299; ICD-9 codes 295, 297, and 298; and ICD-10 codes F20–F29), 4) mood disorders (ICD-8 codes 296 and 300.4; ICD-9 codes 296, 300E, and 311; and ICD-10 codes F30–F39), 5) anxiety, dissociative, stress-related, and somatoform disorders (ICD-8 code 300, except 300.4, and code 307; ICD-9 code 300, except 300.E, and 308–309; and ICD-10 codes F40–F45 and F48), 6) eating disorders (ICD-9 codes 307B and 307F and ICD-10 code F50), 7) psychoactive substance misuse (ICD-8 codes 291, 303, and 304; ICD-9 codes 291, 303, 304, 305A, and 305X; and ICD-10 codes F10–19F), 8) attention-deficit hyperactivity disorder (ICD-9 code 314 and ICD-10 code F90), 9) autism spectrum disorder (ICD-9 code 299 and ICD-10 code F84), 10) intellectual disability (ICD-8 codes 310–315, ICD-9 codes 317–319, and ICD-10 codes F70–F79), and 11) other behavioral disorders (ICD-9 codes 312–313 and ICD-10 codes F91–F98).

Information on sociodemographic characteristics was obtained by linkage to the biological parents through the Multi-Generation Register (16). Parental psychiatric morbidity was defined as at least one event of the following: psychiatric diagnosis (ICD-8 codes 290–315, ICD-9 codes 290–319, and ICD-10 codes F00–F99), suicide attempt (ICD-8/ICD-9 codes E950–E959 and ICD-10 codes X60–X84 in the NPR), or death by suicide (obtained from the Cause of Death Register) (18). Data on parental country of birth came from the Migration Register. Parental level of education was extracted from the Education Register, the LISA database (the longitudinal integration database for health insurance and labor market studies [with Swedish acronym]), and the population censuses from the years of 1970, 1975, and 1985 (19,20). In all patients, the highest level of education obtained by either parent was used in the multivariate analyses. The Medical Birth Register provided data on perinatal factors (21).

Baseline characteristics were compared between probands and controls by a χ² test or Student t test for mean values (Supplementary Table 1). Because of baseline differences between groups, not fully controlled by matching, subsequent analyses were additionally adjusted for covariates. The risk of psychiatric disorders (outcome) related to diagnosis of type 1 diabetes (exposure) was estimated with the Cox proportional hazards model conditioned on the matching variables (sex and year and county of birth). Follow-up began on diagnosis of diabetes (the date of first dose of insulin) and ended with first reported event of the diagnosis of psychiatric disorder, emigration from Sweden, death, or end of the study period (31 January 2010). Censoring dates of death or emigration were extracted from the Cause of Death Register and the Migration Register, respectively (18,22). To control for censored observations, we calculated prevalence of psychiatric disorder by the Kaplan-Meier method. The prevalence of psychiatric disorders was estimated for the 10-year period after the onset of diabetes. This enables further comparison of estimates between cohorts and previously reported clinical samples.

Likewise, using the sibling data, we analyzed the relation between exposure (having a sibling with type 1 diabetes) and outcome of psychiatric disorders with the Cox model. The sibling cohorts were observed since their birth to the end of observation defined as above. Similarly, siblings of control subjects were observed from birth. As a side note, this will automatically result in a slightly higher prevalence among the control subjects to probands compared with control subjects of siblings. A robust sandwich estimator function was used to adjust for family clusters. Missing data were not replaced by any method but categorized as “unknown” for analyses. Statistical analyses were undertaken with SAS software (version 9.3; SAS, Cary, NC). The study was approved by the Regional Ethics Committee at Karolinska Institutet, Stockholm, Sweden.

The mean ± SD age at onset of type 1 diabetes was 9.3 ± 4.5 years. The median follow-up time of the patients with type 1 diabetes was 5.8 years (interquartile range 2.8–9.4).

Baseline characteristics of probands with type 1 diabetes, their healthy siblings, and their matched control subjects are presented in Supplementary Table 1. Parents of probands were more likely to be over 35 years of age at the time of child’s birth, have Scandinavian origin, and have an upper secondary level of education compared with the parents of their peers. Probands seemed to more often be born moderate to late preterm (32–36 gestational age), with high birth weight (>3,500 g) and large for gestational age. In 403 (2.4%) probands, psychiatric disorders were recognized before the onset of type 1 diabetes—significantly more often than among control subjects the same age (N = 33,928 [2.0%]). Subsequent analyses were adjusted to those discrepancies between groups.

In total, psychiatric disorders were recognized in 1,428 (8.3%) probands, of whom 259 had more than one disorder. After adjustment for sociodemograhic and perinatal factors, probands were 2.1 times more likely to receive psychiatric diagnoses and 1.7 times more likely to attempt suicide than control subjects (Table 1). Probands had an increased risk for mood disorders (hazard ratio [HR] 2.0 [95% CI 1.8–2.3]), anxiety disorders (HR 1.6 [95% CI 1.4–2.0]), eating disorders (HR 2.2 [95% CI 1.8–2.6]), substance misuse (HR 2.6 [95% CI 2.4–2.9]), attention-deficit hyperactivity disorder (HR 1.5 [95% CI 1.3–2.7]), behavioral disorders (HR 2.2 [95% CI 2.0–2.4]), autism spectrum disorder (HR 1.7 [95% CI 1.4–2.0]), and intellectual disability (HR 1.8 [95% CI 1.5–2.1]) compared with healthy peers.

Increased risk of suicidal attempts was significant only for diagnoses from inpatient care (HR 1.8 [95% CI 1.5–2.2])—not for outpatient care (HR 1.4 [95% CI 1.0–2.0]; P = 0.07). Other psychiatric diagnoses were significant for both in- and outpatient care (data not shown).

Overall, risk of psychiatric disorders increased with age at onset of type 1 diabetes (age of onset <7 years: HR 1.9 [95% CI 1.7–2.0] vs. age of onset ≥12 years: HR 2.4 [95% CI 2.1–2.6]). The highest risk of psychiatric disorder in all age-groups was noted within the first 6 months after diagnosis of type 1 diabetes and declined with time (Table 2).

The overall prevalence of psychiatric disorders in probands was 11.4% (95% CI 10.8–12.0) in 10 years after the onset of type 1 diabetes in the entire sample. When analyzed by cohort, the 10-year prevalence of psychiatric disorders increased threefold over the period of the study (Table 3). The prevalence was lowest in the cohort with onset of type 1 diabetes in 1973–1986 (4.6% [95% CI 3.7–5.7]), when psychiatric diagnoses were based on the ICD-8 classification. The prevalence of psychiatric disorders doubled in 1987–1996 with ICD-9 (8.4% [95% CI 7.5–9.4]). Introduction of ICD-10 resulted in further increase in prevalence of psychiatric disorders (15.3% [95% CI 14.4–16.3]) in 1997–2009. This was true for all groups of disorders. A similar trend was observed in the healthy control subjects, where the 10-year prevalence of psychiatric disorders was 1.5 (95% CI 1.5–1.6), 3.1 (95% CI 3.0–3.1), and 8.7 (95% CI 8.7–8.8), respectively, for ICD-8, ICD-9, and ICD-10. Interestingly, the risk of psychiatric disorders among probands in comparison with control subjects actually declined (HR 2.7 [95% CI 2.2–3.3] for ICD-8, HR 2.5 [95% CI 2.3–2.8] for ICD-9, and HR 1.9 [95% CI 1.8–2.0] for ICD-10). This trend was particularly evident in suicide attempts, behavioral disorders, and intellectual disabilities (Table 3).

Psychiatric disorders were observed in 1,059 (5.6%) siblings of probands, and 191 of these children received two or more psychiatric diagnoses. The adjusted risk for childhood psychiatric disorders among healthy full siblings of a patient with type 1 diabetes was estimated at HR 1.1 (95% CI 1.0–1.1); for suicide attempts, the HR was 1.2 (95% CI 1.0–1.4; P = 0.12). When analyses were conducted separately for different categories of psychiatric disorders, none of the categories were statistically significant (Table 4).

This is the first large-scale population-based study on risk for psychiatric disorders in children with type 1 diabetes. Our findings support previous clinical observations that these patients are at increased risk for psychiatric morbidity (3,4). We found increased risks for different diagnostic categories of disorders suggesting that psychological assessment restricted to mood and anxiety disorders probably is too limited (23). Furthermore, our findings offer valuable insight into the etiology of psychiatric comorbidity in type 1 diabetes. Lack of risk of psychiatric disorders among siblings of patients suggests that there is no shared genetic susceptibility between those conditions (24).

Our findings provide robust evidence for psychiatric comorbidity in pediatric patients with type 1 diabetes. Previous case-control studies have yielded inconsistent results, primarily due to insufficient power for dichotomous variables (25–28).

Results from this study confirm previous observations on high risk for psychiatric disorders within the first 6 months of diabetes diagnosis. This may be related to a crisis reaction hampering adjustment to treatment requirements, but it may also involve poor disease control in the initial phase (4). A recent study by Cameron at al. (29) demonstrated that impaired mental state in children with new-onset type 1 diabetes may be attributed to the brain injury related to severe ketoacidosis.

Our data provide evidence for cohort effects in the prevalence and the risk of psychiatric disorders among children with type 1 diabetes. In our sample, the prevalence of psychiatric disorders 10 years after onset of type 1 diabetes tripled from 3.8% in those born 1973–1986 to 16.7% for the cohort born 1997–2009. The 10-year prevalence was studied previously by Kovacs et al. (3), who found that 47.6% from the cohort diagnosed with type 1 diabetes between 1981 and 1984 developed psychiatric disorders. However, methodological discrepancies between register-based and case-series observational studies make comparison with this study difficult. Changes in diabetes care such as more demanding insulin regimens and higher responsibility of youths and their caregivers for treatment decisions could theoretically be an explanation for the increased psychological burden in patients with type 1 diabetes in recent years. But similar trends among control subjects suggest that more general factors are responsible for the increased rates of psychiatric disorders. Most likely, this trend is related to changes in ICD classification and secular drift in diagnostic praxis. A meta-analysis showed that in more recent studies, the differences in psychiatric symptoms between children with diabetes and control subjects were actually smaller than observed previously (25). When we stratified our analysis on the time of diabetes diagnosis, we noted steady decline in the relative risk of psychiatric disorders among probands compared with control subjects. This suggests that advances in diabetes care made over the past four decades, such as the introduction of an intensive insulin treatment in children allowing more flexible lifestyle and dietary freedom compared with conventional insulin regimen, might be associated with the reduced risk of mental health problems.

We showed that psychiatric comorbidity in children with type 1 diabetes is more complex than previously thought. Diabetes increased risk for most categories of psychiatric disorders, and almost one-fifth of children with diabetes and psychiatric disorders had two or more psychiatric disorders. This supports existing recommendations of comprehensive care of children with type 1 diabetes (26). Regular screening for disorders with available simple measures (i.e., mood and anxiety disorders) would be valuable. A close cooperation between pediatric diabetes teams and mental health professionals is needed to monitor the mental health in children with type 1 diabetes.

Our findings also have implications for etiological research, as comorbidity between two diseases may result from common etiological risk factors. Shared genetic susceptibility has previously been proposed as a rationale for higher risk of autism spectrum disorders in type 1 diabetes (27). To assess whether this hypothesis may explain psychiatric comorbidity in type 1 diabetes, we evaluated the risk of different groups of psychiatric disorders also in healthy siblings of children with type 1 diabetes. We expected that healthy siblings should have, similar to their brothers and sisters with diabetes, higher risk of psychiatric disorders than the general population. Slightly higher risk of any psychiatric disorder was noted among the siblings. However, despite adequate power (>80% for HR 1.2) no increased risk was found in any specific category of psychiatric disorders that might share genetic susceptibility with type 1 diabetes. These results suggest that associations between type 1 diabetes and psychiatric disorders are due to biological and/or psychological effects of diabetes (i.e., consistent with a causal effect) rather than common genetic risk factors or within family environmental factors.

Strengths of our study include a large-scale population-based design, prospectively collected data from nationwide registries, control for several possible confounders, follow-up period up to adulthood, definitions of outcome as diagnosed disorders justifying clinical intervention, and analysis of genetically informed data on siblings. Nevertheless, our study does have some limitations related to register-based methodology. Children with type 1 diabetes are under regular diabetological care. High risk of psychiatric diagnoses in this population may be biased by care-seeking attitudes of parents adjusted to high use of the health care system. Still, the results for healthy siblings do not suggest that families with diabetes were more likely to seek help for psychiatric care for their children. Furthermore, one may argue that diabetologists could notice symptoms that otherwise would not have been recognized and initiated referral to mental health services, and this diagnostic bias could account for higher rates of psychiatric disorders in children with type 1 diabetes. Lack of detailed clinical data was another limitation of the study. Noncompliance and persistent high level of glycated hemoglobin in type 1 diabetes is a risk factor for psychiatric comorbidity and neurodevelopmental problems (28,30,31). However, we had no data on metabolic control of disease, since medical records were unavailable.

In summary, our results have important clinical implications. First, high risk of psychiatric disorders in children with type 1 diabetes highlights the need for mental health service as part of gold standard medical management in this population, and psychological care should start from the date of diagnosis of diabetes. Second, our findings draw attention to the complexity of psychiatric disorders accompanying type 1 diabetes. Design of cost-effective algorithms aimed at identifying children at risk for having psychiatric comorbidity poses a challenge. Third, this report challenges the single-disease approach, which dominates the health systems, medical education, and clinical research. This attitude has recently been questioned, and the need for comprehensive care has been recognized (32). Although physical-mental health comorbidity is mostly attributed to the elderly, our study shows that the pediatric population is not free from such difficulties, and child health care needs to rise up to this challenge.

Acknowledgments. The authors thank Wojciech Fendler from the Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, for his constructive clinical comments.

Funding. This study was funded by the Polish Ministry of Science and Higher Education (903/MOB/2012/0 and IP2012 006972); the National Institute of Child Health and Human Developmenthttp://dx.doi.org/10.13039/100000071 (HD061817); the Swedish Research Council (523-2011-3807); the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) framework grants (340-2013-5867); the Regional Agreement on Medical Training and Clinical Research between Stockholm County Council and Karolinska Institutet; the Swedish Heart-Lung Foundation; the Strategic Research Program in Epidemiology at Karolinska Institutet; and the Swedish Research Council for Health, Working Life and Welfare. The Swedish Association of Local Authorities and Regions funds the NDR.

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Author Contributions. A.B. conceived the idea, designed the study, performed statistical analyses, and wrote the first draft. L.F., C.A., and B.Z. participated in discussion. P.L. supervised the study design and statistical analyses. All authors interpreted the results, revised the manuscript, and approved the final version of the manuscript. A.B. and P.L. are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Prior Presentation. Parts of this study were presented in abstract form at the 21st European Congress of Psychiatry, Nice, France, 6–9 April 2013.