Plasma free insulin profiles in insulin-dependent diabetic subjects were compared after jet and syringe injection of insulin. Jet injection of insulin resulted in a shift of the free insulin profile to the left. Thus higher plasma free insulin levels were found over the first 30 min after injection (P < 0.05), while after 240 min plasma free insulin levels were lower than those seen following syringe injection (P < 0.05). Significant differences in the response of blood glucose and 3-hydroxybutyrate levels reflected the differences in plasma free insulin levels. Jet administration results in more rapid absorption of insulin and could be useful in providing a more physiologic postprandial insulin profile than that seen after conventional injection.
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Brief Communications|
May 01 1981
Plasma Free Insulin Profiles After Administration of Insulin by Jet and Conventional Syringe Injection
Roy Taylor;
Roy Taylor
Department of Clinical Biochemistry and Metabolic Medicine
Newscastle upon Tyne
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Philip D Home;
Philip D Home
Department of Clinical Biochemistry and Metabolic Medicine
Newscastle upon Tyne
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K George M M Alberti
K George M M Alberti
Department of Clinical Biochemistry and Metabolic Medicine
Newscastle upon Tyne
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Address reprint requests to Philip Home, Department of Clinical Biochemistry and Metabolic Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP England.
Citation
Roy Taylor, Philip D Home, K George M M Alberti; Plasma Free Insulin Profiles After Administration of Insulin by Jet and Conventional Syringe Injection. Diabetes Care 1 May 1981; 4 (3): 377–379. https://doi.org/10.2337/diacare.4.3.377
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