To investigate vascular responses in insulin-dependent diabetic patients both with and without retinopathy, we have assessed vasodilation by forearm transcutaneous pO2 measurement after 10 min of ischemia produced by a sphygmomanometer cuff. Diabetic patients with proliferative retinopathy had a delayed vasodilatory response at 60 s (mean ± SD pO2 = 9 ± 3 mm Hg) compared with those having diabetes without retinopathy (15 ± 4 mm Hg, P < 0.01) and matched normal subjects (14 ± 4 mm Hg, P < 0.01). Recently diagnosed insulin-dependent diabetic patients had a very similar response (15 ± 5 mm Hg) to matched normal subjects (15 ± 3 mm Hg). The diminished vascular reactivity may be a consequence of microangiopathy and neuropathy, although patients with an impaired vascular response might be particularly at risk from the development of capillary closure.
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Original Articles| January 01 1984
Delayed Vascular Reactivity to Ischemia in Diabetic Microangiopathy
B Haitas, M.B.;
A Barnes, A.I.M.L.S.;
M E C Shogry, B.A.;
M Weindling, M.R.C.P.;
P Rolfe, Ph.D.;
Address reprint requests to Dr. R. C. Turner, Diabetes Research Laboratories, Radcliffe Infirmary, Woodstock Road, Oxford 0X2 6HE, United Kingdom.
Diabetes Care 1984;7(1):47–51
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B Haitas, A Barnes, M E C Shogry, M Weindling, P Rolfe, R C Turner; Delayed Vascular Reactivity to Ischemia in Diabetic Microangiopathy. Diabetes Care 1 January 1984; 7 (1): 47–51. https://doi.org/10.2337/diacare.7.1.47
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