The insulin response to a 100-g oral glucose load was studied in 40 obese (percent desirable weight ≥ 120%) and 40 nonobese (< 120%) age- and sex-matched Indian patients with non-insulin-dependent diabetes in the young. There were no significant differences between the obese and nonobese patients with respect to their insulin and glucose responses. Thus, it appears that obesity does not exert a significant modulating effect on insulin secretion in patients with fasting hyperglycemia.

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