The effect of lipohypertrophy at injection sites on insulin absorption has been studied in 12 insulin-dependent diabetic patients. The clearance of 125 I-insulin from sites with lipohypertrophy was significantly slower than from complementary nonhypertrophied sites (% clearance in 3 h, 43.8 ± 3.5 ± SEM) control; 35.3 ± 3.9 lipohypertrophy, P < 0.05). The degree of the effect was variable but sufficient in several patients to be of clinical importance. Injection-site lipohypertrophy is another factor that modifies the absorption of subcutaneously injected insulin.
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Brief Communications| September 01 1984
Diabetic Lipohypertrophy Delays Insulin Absorption
Robert J Young, M.R.C.P.;
W James Hannan, Ph.D.;
Brian M Frier, M.D.;
Judith M Steel, F.R.C.P.;
Address reprint requests to R. J. Young, M.R.C.P., Diabetic Department, Royal Infirmary, Edinburgh, Scotland EH3 9YW.
Diabetes Care 1984;7(5):479–480
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Robert J Young, W James Hannan, Brian M Frier, Judith M Steel, Leslie J P Duncan; Diabetic Lipohypertrophy Delays Insulin Absorption. Diabetes Care 1 September 1984; 7 (5): 479–480. https://doi.org/10.2337/diacare.7.5.479
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