Nephropathy in Indian Patients with Non-insulin-dependent Diabetes in the Young

In 85 patients diagnosed as having non-insulin-dependent diabetes in the young (NIDDY), 6 were found to have nephropathy. The duration of diabetes ranged from 2 to 17 yr; 5 of the 6 patients had retinopathy as evidenced by fluoroscein angiography (3 with proliferative changes). All 6 patients had a 24-h urinary protein excretion >0.5 g and a glomerular filtration rate <80 ml/min. Serum β₂-microglobulin levels were increased in all 6 patients, while only 3 had increased serum creatinine levels.