The endogenous insulin secretion capacity of 171 insulin-treated middle-aged persons with diabetes (81 men, 90 women) of the Kuopio University Central Hospital district (population 250,000), East Finland, was measured by the C-peptide response to glucagori. The prevalence of insulin deficiency among initially non-insulin-dependent diabetic (NIDDM) individuals was calculated on the basis of those who were initially treated with diet or oral drugs and 3 yr or more after diagnosis had been treated with insulin and were insulin deficient in this study. The prevalence of complete insulin deficiency (postglucagon C-peptide undetectable) was among initially NIDDM individuals of the same region, 0.7% in menand 1.2% in women. Using the postglucagon C-peptide level of 0.20 nmol/L as a cut-offpoint, the prevalence of insulin deficiency was 2.0% in men and 1.9% in women and, on thebasis of C-peptide level of 0.60 nmol/L, the prevalence of insulin deficiency was 3.5% in men and 2.7% in women. Our data suggest that the deterioration of insulin secretion capacity in NIDDM to the level that leads to insulin dependency occurs less often than has been previously suggested.
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Original Articles|
May 01 1986
Prevalence of Insulin Deficiency Among Initially Non-Insulin-Dependent Middle-Aged Diabetic Individuals
Markku Laakso, MD;
Markku Laakso, MD
Department of Medicine, Kuopio University Central Hospital
70210 Kuopio 21, Finland
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Helena Sarlund, MD;
Helena Sarlund, MD
Department of Medicine, Kuopio University Central Hospital
70210 Kuopio 21, Finland
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Kalevi Pyörälä, MD
Kalevi Pyörälä, MD
Department of Medicine, Kuopio University Central Hospital
70210 Kuopio 21, Finland
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Address reprint requests to Markku Laakso, M.D., at the above address.
Citation
Markku Laakso, Helena Sarlund, Kalevi Pyörälä; Prevalence of Insulin Deficiency Among Initially Non-Insulin-Dependent Middle-Aged Diabetic Individuals. Diabetes Care 1 May 1986; 9 (3): 228–231. https://doi.org/10.2337/diacare.9.3.228
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