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Volume 34, Issue Supplement_2

May 2011

Cover Image

Cover Image
Table of Contents

ISSN 0149-5992

EISSN 1935-5548

In this Issue

Diabetes, Obesity and Hypertension Outcome Studies
Diabetes and Cardiovascular Disease
Diabetes
Diabetes Treatments
Hypertension
Obesity / Lipids
Introduction

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Diabetes, Obesity and Hypertension Outcome Studies

Impact of the U.S. Food and Drug Administration Cardiovascular Assessment Requirements on the Development of Novel Antidiabetes Drugs

Boaz Hirshberg, MD; Itamar Raz, MD

View articletitled, Impact of the U.S. Food and Drug Administration Cardiovascular Assessment Requirements on the Development of Novel Antidiabetes Drugs

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Diabetes Care April 2011, Vol.34, S101-S106. doi:https://doi.org/10.2337/dc11-s202

The ACCORD (Action to Control Cardiovascular Risk in Diabetes) Lipid Trial: What we learn from subgroup analyses

Henry N. Ginsberg, MD

View articletitled, The ACCORD (Action to Control Cardiovascular Risk in Diabetes) Lipid Trial<span class="subtitle-colon">: </span><span class="subtitle">What we learn from subgroup analyses</span>

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Diabetes Care April 2011, Vol.34, S107-S108. doi:https://doi.org/10.2337/dc11-s203

Diabetes, Hypertension, and Outcome Studies: Overview 2010

Peter M. Nilsson, MD; Jan Cederholm, MD

View articletitled, Diabetes, Hypertension, and Outcome Studies: Overview 2010

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Diabetes Care April 2011, Vol.34, S109-S113. doi:https://doi.org/10.2337/dc11-s204

Sibutramine on Cardiovascular Outcome

André J. Scheen, MD

View articletitled, Sibutramine on Cardiovascular Outcome

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Diabetes Care April 2011, Vol.34, S114-S119. doi:https://doi.org/10.2337/dc11-s205

Diabetes and Cardiovascular Disease

Postprandial Hyperglycemia and Glycemic Variability: Should we care?

Eberhard Standl, MD; Oliver Schnell, MD; Antonio Ceriello, MD

View articletitled, Postprandial Hyperglycemia and Glycemic Variability<span class="subtitle-colon">: </span><span class="subtitle">Should we care?</span>

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Diabetes Care April 2011, Vol.34, S120-S127. doi:https://doi.org/10.2337/dc11-s206

Is Hyperglycemia a Cardiovascular Risk Factor?

Frank Pistrosch, MD; Andrea Natali, MD; Markolf Hanefeld, MD

View articletitled, Is Hyperglycemia a Cardiovascular Risk Factor?

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Diabetes Care April 2011, Vol.34, S128-S131. doi:https://doi.org/10.2337/dc11-s207

Hypoglycemia and Cardiovascular Risks

Brian M. Frier, MD; Guntram Schernthaner, MD; Simon R. Heller, MD

View articletitled, Hypoglycemia and Cardiovascular Risks

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Diabetes Care April 2011, Vol.34, S132-S137. doi:https://doi.org/10.2337/dc11-s220

Heart in Diabetes: Not Only a Macrovascular Disease

Bernd Stratmann, PHD; Diethelm Tschoepe, MD

View articletitled, Heart in Diabetes: Not Only a Macrovascular Disease

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Diabetes Care April 2011, Vol.34, S138-S144. doi:https://doi.org/10.2337/dc11-s208

Heart in Diabetes: A Microvascular Disease

Markku Laakso, MD

View articletitled, Heart in Diabetes: A Microvascular Disease

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Diabetes Care April 2011, Vol.34, S145-S149. doi:https://doi.org/10.2337/dc11-s209

Antiplatelet Therapy for Every Diabetic Person?

Antonio Nicolucci, MD; Eberhard Standl, MD

View articletitled, Antiplatelet Therapy for Every Diabetic Person?

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Diabetes Care April 2011, Vol.34, S150-S154. doi:https://doi.org/10.2337/dc11-s210

Should C-Reactive Protein Be a Target of Therapy?

Jisun Oh, MD; Hwee Teoh, PHD; Lawrence A. Leiter, MD

View articletitled, Should C-Reactive Protein Be a Target of Therapy?

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Diabetes Care April 2011, Vol.34, S155-S160. doi:https://doi.org/10.2337/dc11-s211

Diabetes

Type 2 Diabetes in Youth: Epidemiology and Pathophysiology

Ebe D’Adamo, MD; Sonia Caprio, MD

View articletitled, Type 2 Diabetes in Youth: Epidemiology and Pathophysiology

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Diabetes Care April 2011, Vol.34, S161-S165. doi:https://doi.org/10.2337/dc11-s212

Obesity, Autoimmunity, and Double Diabetes in Youth

Paolo Pozzilli, MD; Chiara Guglielmi, MD; Sonia Caprio, MD; Raffaella Buzzetti, MD

View articletitled, Obesity, Autoimmunity, and Double Diabetes in Youth

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Diabetes Care April 2011, Vol.34, S166-S170. doi:https://doi.org/10.2337/dc11-s213

Childhood Metabolic Syndrome: Must we define it to deal with it?

Ram Weiss, MD

View articletitled, Childhood Metabolic Syndrome<span class="subtitle-colon">: </span><span class="subtitle">Must we define it to deal with it?</span>

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Diabetes Care April 2011, Vol.34, S171-S176. doi:https://doi.org/10.2337/dc11-s214

Treatment of Type 2 Diabetes in Youth

Amanda Flint, MD; Silva Arslanian, MD

View articletitled, Treatment of Type 2 Diabetes in Youth

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Diabetes Care April 2011, Vol.34, S177-S183. doi:https://doi.org/10.2337/dc11-s215

The Pros and Cons of Diagnosing Diabetes With A1C

Enzo Bonora, MD; Jaakko Tuomilehto, MD

View articletitled, The Pros and Cons of Diagnosing Diabetes With A1C

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Diabetes Care April 2011, Vol.34, S184-S190. doi:https://doi.org/10.2337/dc11-s216

Should A1C Targets Be Individualized for All People With Diabetes?: Arguments for and against

Hwee Teoh, PHD; Philip Home, DM; Lawrence A. Leiter, MD

View articletitled, Should A1C Targets Be Individualized for All People With Diabetes?<span class="subtitle-colon">: </span><span class="subtitle">Arguments for and against</span>

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Diabetes Care April 2011, Vol.34, S191-S196. doi:https://doi.org/10.2337/dc11-s217

Current Application of Continuous Glucose Monitoring in the Treatment of Diabetes: Pros and cons

Jeroen Hermanides, MD; Moshe Phillip, MD,; J. Hans DeVries, MD,

View articletitled, Current Application of Continuous Glucose Monitoring in the Treatment of Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Pros and cons</span>

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Diabetes Care April 2011, Vol.34, S197-S201. doi:https://doi.org/10.2337/dc11-s219

Diabetes Treatments

Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention

Ralph A. DeFronzo, MD; Muhammad Abdul-Ghani, MD

View articletitled, Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention

Supplementary data

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Diabetes Care April 2011, Vol.34, S202-S209. doi:https://doi.org/10.2337/dc11-s221

Long-Term Benefits From Lifestyle Interventions for Type 2 Diabetes Prevention: Time to expand the efforts

Jaakko Tuomilehto, MD; Peter Schwarz, MD; Jaana Lindström, PHD

View articletitled, Long-Term Benefits From Lifestyle Interventions for Type 2 Diabetes Prevention<span class="subtitle-colon">: </span><span class="subtitle">Time to expand the efforts</span>

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Diabetes Care April 2011, Vol.34, S210-S214. doi:https://doi.org/10.2337/dc11-s222

Safety of PPAR Agonists

Philip Home, DM

View articletitled, Safety of PPAR Agonists

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Diabetes Care April 2011, Vol.34, S215-S219. doi:https://doi.org/10.2337/dc11-s233

Pivotal Role of Timely Basal Insulin Replacement After Metformin Failure in Sustaining Long-Term Blood Glucose Control at a Target in Type 2 Diabetes

Geremia B. Bolli, MD; Paola Lucidi, MD; Francesca Porcellati, MD; Carmine G. Fanelli, MD

View articletitled, Pivotal Role of Timely Basal Insulin Replacement After Metformin Failure in Sustaining Long-Term Blood Glucose Control at a Target in Type 2 Diabetes

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Diabetes Care April 2011, Vol.34, S220-S224. doi:https://doi.org/10.2337/dc11-s224

Insulin: Potential Negative Consequences of Early Routine Use in Patients With Type 2 Diabetes

Harold E. Lebovitz, MD

View articletitled, Insulin: Potential Negative Consequences of Early Routine Use in Patients With Type 2 Diabetes

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Diabetes Care April 2011, Vol.34, S225-S230. doi:https://doi.org/10.2337/dc11-s225

Multidrug Treatment of Type 2 Diabetes: A challenge for compliance

Roberto Miccoli, MD; Giuseppe Penno, MD; Stefano Del Prato, MD

View articletitled, Multidrug Treatment of Type 2 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">A challenge for compliance</span>

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Diabetes Care April 2011, Vol.34, S231-S235. doi:https://doi.org/10.2337/dc11-s235

Glucokinase Activators for Diabetes Therapy: May 2010 status report

Franz M. Matschinsky, MD; Bogumil Zelent, PHD; Nicolai Doliba, PHD; Changhong Li, PHD; Jane M. Vanderkooi, PHD; Ali Naji, PHD; Ramakanth Sarabu, PHD; Joseph Grimsby, PHD

View articletitled, Glucokinase Activators for Diabetes Therapy<span class="subtitle-colon">: </span><span class="subtitle">May 2010 status report</span>

Supplementary data

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Diabetes Care April 2011, Vol.34, S236-S243. doi:https://doi.org/10.2337/dc11-s236

Role of Bile Acid Sequestrants in the Treatment of Type 2 Diabetes

Yehuda Handelsman, MD

View articletitled, Role of Bile Acid Sequestrants in the Treatment of Type 2 Diabetes

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Diabetes Care April 2011, Vol.34, S244-S250. doi:https://doi.org/10.2337/dc11-s237

Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

Jens J. Holst, MD; Filip K. Knop, MD; Tina Vilsbøll, MD; Thure Krarup, MD; Sten Madsbad, MD

View articletitled, Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

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Diabetes Care April 2011, Vol.34, S251-S257. doi:https://doi.org/10.2337/dc11-s227

Incretin Effects on β-Cell Function, Replication, and Mass: The human perspective

Alan J. Garber, MD

View articletitled, Incretin Effects on β-Cell Function, Replication, and Mass<span class="subtitle-colon">: </span><span class="subtitle">The human perspective</span>

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Diabetes Care April 2011, Vol.34, S258-S263. doi:https://doi.org/10.2337/dc11-s230

Therapy in the Early Stage: Incretins

Simona Cernea, MD; Itamar Raz, MD

View articletitled, Therapy in the Early Stage: Incretins

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Diabetes Care April 2011, Vol.34, S264-S271. doi:https://doi.org/10.2337/dc11-s223

Glycemic Control Impact on Body Weight Potential to Reduce Cardiovascular Risk: Glucagon-like peptide 1 agonists

Giorgio Sesti, MD

View articletitled, Glycemic Control Impact on Body Weight Potential to Reduce Cardiovascular Risk<span class="subtitle-colon">: </span><span class="subtitle">Glucagon-like peptide 1 agonists</span>

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Diabetes Care April 2011, Vol.34, S272-S275. doi:https://doi.org/10.2337/dc11-s228

DPP-4 Inhibitors: Impact on glycemic control and cardiovascular risk factors

Dror Dicker, MD

View articletitled, DPP-4 Inhibitors<span class="subtitle-colon">: </span><span class="subtitle">Impact on glycemic control and cardiovascular risk factors</span>

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Diabetes Care April 2011, Vol.34, S276-S278. doi:https://doi.org/10.2337/dc11-s229

Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A review of their efficacy and tolerability

Alan J. Garber, MD

View articletitled, Long-Acting Glucagon-Like Peptide 1 Receptor Agonists<span class="subtitle-colon">: </span><span class="subtitle">A review of their efficacy and tolerability</span>

Supplementary data

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Diabetes Care April 2011, Vol.34, S279-S284. doi:https://doi.org/10.2337/dc11-s231

Hypertension

Endothelial Dysfunction in Diabetes: The role of reparatory mechanisms

Angelo Avogaro, MD; Mattia Albiero, PHD; Lisa Menegazzo, PHD; Saula de Kreutzenberg, MD; Gian Paolo Fadini, MD

View articletitled, Endothelial Dysfunction in Diabetes<span class="subtitle-colon">: </span><span class="subtitle">The role of reparatory mechanisms</span>

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Diabetes Care April 2011, Vol.34, S285-S290. doi:https://doi.org/10.2337/dc11-s239

Endothelial Factors and Diabetic Nephropathy

Janaka Karalliedde, MRCP; Luigi Gnudi, MD

View articletitled, Endothelial Factors and Diabetic Nephropathy

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Diabetes Care April 2011, Vol.34, S291-S296. doi:https://doi.org/10.2337/dc11-s241

Benefits of Tight Blood Pressure Control in Diabetic Patients With Hypertension: Importance of early and sustained implementation of effective treatment strategies

Gianfranco Parati, MD; Grzegorz Bilo, MD; Juan E. Ochoa, MD

View articletitled, Benefits of Tight Blood Pressure Control in Diabetic Patients With Hypertension<span class="subtitle-colon">: </span><span class="subtitle">Importance of early and sustained implementation of effective treatment strategies</span>

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Diabetes Care April 2011, Vol.34, S297-S303. doi:https://doi.org/10.2337/dc11-s243

Antihypertensive Treatment and Blood Pressure in Diabetic and Nondiabetic Patients: The lower, the better?

Giuseppe Mancia, MD; Guido Grassi, MD; Alberto Zanchetti, MD

View articletitled, Antihypertensive Treatment and Blood Pressure in Diabetic and Nondiabetic Patients<span class="subtitle-colon">: </span><span class="subtitle">The lower, the better?</span>

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Diabetes Care April 2011, Vol.34, S304-S307. doi:https://doi.org/10.2337/dc11-s244

Blood Pressure: The Lower, the Better: The con side

Ehud Grossman, MD

View articletitled, Blood Pressure: The Lower, the Better<span class="subtitle-colon">: </span><span class="subtitle">The con side</span>

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Diabetes Care April 2011, Vol.34, S308-S312. doi:https://doi.org/10.2337/dc11-s245

Diuretic Treatment of Hypertension

Ehud Grossman, MD; Paolo Verdecchia, MD; Ari Shamiss, MD; Fabio Angeli, MD; Gianpaolo Reboldi, MD

View articletitled, Diuretic Treatment of Hypertension

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Diabetes Care April 2011, Vol.34, S313-S319. doi:https://doi.org/10.2337/dc11-s246

RAS Blockade for Every Diabetic Patient: Pro and Con

Luis M. Ruilope, MD; Anna Solini, MD

View articletitled, RAS Blockade for Every Diabetic Patient: Pro and Con

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Diabetes Care April 2011, Vol.34, S320-S324. doi:https://doi.org/10.2337/dc11-s248

Monitoring Kidney Function and Albuminuria in Patients With Diabetes

Hiddo J. Lambers Heerspink, PHARMD; Frank A. Holtkamp, PHARMD; Dick de Zeeuw, MD; Mordchai Ravid, MD

View articletitled, Monitoring Kidney Function and Albuminuria in Patients With Diabetes

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Diabetes Care April 2011, Vol.34, S325-S329. doi:https://doi.org/10.2337/dc11-s247

Limitations and Future Treatment Options in Type 2 Diabetes With Renal Impairment

Eberhard Ritz, MD

View articletitled, Limitations and Future Treatment Options in Type 2 Diabetes With Renal Impairment

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Diabetes Care April 2011, Vol.34, S330-S334. doi:https://doi.org/10.2337/dc11-s242

Obesity / Lipids

Antimicrobial-Sensing Proteins in Obesity and Type 2 Diabetes: The buffering efficiency hypothesis

José María Moreno-Navarrete, PHD; José Manuel Fernández-Real, MD

View articletitled, Antimicrobial-Sensing Proteins in Obesity and Type 2 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">The buffering efficiency hypothesis</span>

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Diabetes Care April 2011, Vol.34, S335-S341. doi:https://doi.org/10.2337/dc11-s238

Meal-Related Increases in Microvascular Vasomotion Are Impaired in Obese Individuals: A potential mechanism in the pathogenesis of obesity-related insulin resistance

Amy M. Jonk, MSC; Alfons J. Houben, PHD; Nicolaas C. Schaper, MD; Peter W. de Leeuw, MD; Erik H. Serné, MD; Yvo M. Smulders, MD; Coen D. Stehouwer, MD

View articletitled, Meal-Related Increases in Microvascular Vasomotion Are Impaired in Obese Individuals<span class="subtitle-colon">: </span><span class="subtitle">A potential mechanism in the pathogenesis of obesity-related insulin resistance</span>

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Diabetes Care April 2011, Vol.34, S342-S348. doi:https://doi.org/10.2337/dc11-s240

Comparative Efficiency and Safety of Pharmacological Approaches to the Management of Obesity

Vojtech Hainer, MD

View articletitled, Comparative Efficiency and Safety of Pharmacological Approaches to the Management of Obesity

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Diabetes Care April 2011, Vol.34, S349-S354. doi:https://doi.org/10.2337/dc11-s255

Cure of Type 2 Diabetes by Metabolic Surgery? A Critical Analysis of the Evidence in 2010

Guntram Schernthaner, MD; Johanna M. Brix, MD; Hans-Peter Kopp, MD; Gerit Holger Schernthaner, MD

View articletitled, Cure of Type 2 Diabetes by Metabolic Surgery? A Critical Analysis of the Evidence in 2010

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Diabetes Care April 2011, Vol.34, S355-S360. doi:https://doi.org/10.2337/dc11-s253

Bariatric Surgery for Type 2 Diabetes Reversal: The Risks

Andrei Keidar, MD

View articletitled, Bariatric Surgery for Type 2 Diabetes Reversal: The Risks

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Diabetes Care April 2011, Vol.34, S361-S266. doi:https://doi.org/10.2337/dc11-s254

Lipids in the Wrong Place: Visceral Fat and Nonalcoholic Steatohepatitis

Gianluca Perseghin, MD

View articletitled, Lipids in the Wrong Place: Visceral Fat and Nonalcoholic Steatohepatitis

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Diabetes Care April 2011, Vol.34, S367-S370. doi:https://doi.org/10.2337/dc11-s249

Myocardial, Perivascular, and Epicardial Fat

Patricia Iozzo, MD

View articletitled, Myocardial, Perivascular, and Epicardial Fat

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Diabetes Care April 2011, Vol.34, S371-S379. doi:https://doi.org/10.2337/dc11-s250

Diabetes and Cardiovascular Disease: When it comes to lipids, statins are all you need

Rafael Bitzur, MD

View articletitled, Diabetes and Cardiovascular Disease<span class="subtitle-colon">: </span><span class="subtitle">When it comes to lipids, statins are all you need</span>

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Diabetes Care April 2011, Vol.34, S380-S382. doi:https://doi.org/10.2337/dc11-s256

Introduction

Introduction to the Third World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy): Outcome studies versus clinical experience in the treatment of diabetes

Itamar Raz, MD; Stefano Del Prato, MD

View articletitled, Introduction to the Third World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)<span class="subtitle-colon">: </span><span class="subtitle">Outcome studies versus clinical experience in the treatment of diabetes</span>

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Diabetes Care April 2011, Vol.34, S99-S100. doi:https://doi.org/10.2337/dc11-s201

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