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1 June 2014
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ISSN 0149-5992
EISSN 1935-5548
In this Issue
In This Issue
In This Issue of Diabetes Care
Diabetes Care May 2014, Vol.37, 1497-1498. doi:https://doi.org/10.2337/dc14-ti06
Perspectives in Care
Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges?
Philip Home; Matthew Riddle; William T. Cefalu; Clifford J. Bailey; Reinhard G. Bretzel; Stefano del Prato; Derek Leroith; Guntram Schernthaner; Luc van Gaal; Itamar Raz
Diabetes Care May 2014, Vol.37, 1499-1508. doi:https://doi.org/10.2337/dc13-2743
Clinical Care / Education / Nutrition / Psychosocial Research
Glucagon-Like Peptide 1 Attenuates the Acceleration of Gastric Emptying Induced by Hypoglycemia in Healthy Subjects
Mark P. Plummer; Karen L. Jones; Chris E. Annink; Caroline E. Cousins; Juris J. Meier; Marianne J. Chapman; Michael Horowitz; Adam M. Deane
Diabetes Care May 2014, Vol.37, 1509-1515. doi:https://doi.org/10.2337/dc13-1813
Intensive Versus Intermediate Glucose Control in Surgical Intensive Care Unit Patients
Takehiro Okabayashi; Yasuo Shima; Tatsuaki Sumiyoshi; Akihito Kozuki; Teppei Tokumaru; Tasuo Iiyama; Takeki Sugimoto; Michiya Kobayashi; Masataka Yokoyama; Kazuhiro Hanazaki
Diabetes Care May 2014, Vol.37, 1516-1524. doi:https://doi.org/10.2337/dc13-1771
Comparative Effectiveness of Peer Leaders and Community Health Workers in Diabetes Self-management Support: Results of a Randomized Controlled Trial
Tricia S. Tang; Martha Funnell; Brandy Sinco; Gretchen Piatt; Gloria Palmisano; Michael S. Spencer; Edith C. Kieffer; Michele Heisler
Diabetes Care May 2014, Vol.37, 1525-1534. doi:https://doi.org/10.2337/dc13-2161
Randomized Clinical Trial of Clinic-Integrated, Low-Intensity Treatment to Prevent Deterioration of Disease Care in Adolescents With Type 1 Diabetes
Diabetes Care May 2014, Vol.37, 1535-1543. doi:https://doi.org/10.2337/dc13-1053
Impact of Intensive Lifestyle Intervention on Depression and Health-Related Quality of Life in Type 2 Diabetes: The Look AHEAD Trial
Diabetes Care May 2014, Vol.37, 1544-1553. doi:https://doi.org/10.2337/dc13-1928
Neurological Consequences of Diabetic Ketoacidosis at Initial Presentation of Type 1 Diabetes in a Prospective Cohort Study of Children
Fergus J. Cameron; Shannon E. Scratch; Caroline Nadebaum; Elisabeth A. Northam; Ildiko Koves; Juliet Jennings; Kristina Finney; Jeffrey J. Neil; R. Mark Wellard; Mark Mackay; Terrie E. Inder; on behalf of the DKA Brain Injury Study Group
Diabetes Care May 2014, Vol.37, 1554-1562. doi:https://doi.org/10.2337/dc13-1904
Depression in Adults in the T1D Exchange Clinic Registry
Paula M. Trief; Dongyuan Xing; Nicole C. Foster; David M. Maahs; Julie M. Kittelsrud; Beth A. Olson; Laura A. Young; Anne L. Peters; Richard M. Bergenstal; Kellee M. Miller; Roy W. Beck; Ruth S. Weinstock; for the T1D Exchange Clinic Network
Diabetes Care May 2014, Vol.37, 1563-1572. doi:https://doi.org/10.2337/dc13-1867
Weight Loss, Glycemic Control, and Cardiovascular Disease Risk Factors in Response to Differential Diet Composition in a Weight Loss Program in Type 2 Diabetes: A Randomized Controlled Trial
Cheryl L. Rock; Shirley W. Flatt; Bilge Pakiz; Kenneth S. Taylor; Angela F. Leone; Kerrin Brelje; Dennis D. Heath; Elizabeth L. Quintana; Nancy E. Sherwood
Diabetes Care May 2014, Vol.37, 1573-1580. doi:https://doi.org/10.2337/dc13-2900
Epidemiology / Health Services Research
Clinical Characteristics and Outcome of 467 Patients With a Clinically Recognized Eating Disorder Identified Among 52,215 Patients With Type 1 Diabetes: A Multicenter German/Austrian Study
Nicole Scheuing; Béla Bartus; Gabriele Berger; Holger Haberland; Andrea Icks; Burkhild Knauth; Nicole Nellen-Hellmuth; Joachim Rosenbauer; Martin Teufel; Reinhard W. Holl; on behalf of the DPV Initiative; the German BMBF Competence Network Diabetes Mellitus
Diabetes Care May 2014, Vol.37, 1581-1589. doi:https://doi.org/10.2337/dc13-2156
Trends in Incidence of Diabetes in Pregnancy and Serious Perinatal Outcomes: A Large, Population-Based Study in Ontario, Canada, 1996–2010
Denice S. Feig; Jeremiah Hwee; Baiju R. Shah; Giliian L. Booth; Arlene S. Bierman; Lorraine L. Lipscombe
Diabetes Care May 2014, Vol.37, 1590-1596. doi:https://doi.org/10.2337/dc13-2717
Insulin Sensitivity and Albuminuria: The RISC Study
Stefan Pilz; Femke Rutters; Giel Nijpels; Coen D.A. Stehouwer; Kurt Højlund; John J. Nolan; Beverley Balkau; Jacqueline M. Dekker; the RISC Investigators
Diabetes Care May 2014, Vol.37, 1597-1603. doi:https://doi.org/10.2337/dc13-2573
The Association Between Patient-Reported Self-management Behavior, Intermediate Clinical Outcomes, and Mortality in Patients With Type 2 Diabetes: Results From the KORA-A Study
Michael Laxy; Andreas Mielck; Matthias Hunger; Michaela Schunk; Christa Meisinger; Ina-Maria Rückert; Wolfgang Rathmann; Rolf Holle
Diabetes Care May 2014, Vol.37, 1604-1612. doi:https://doi.org/10.2337/dc13-2533
Interarm Blood Pressure Difference in People With Diabetes: Measurement and Vascular and Mortality Implications: A Cohort Study
Christopher E. Clark; Anna M. Steele; Rod S. Taylor; Angela C. Shore; Obioha C. Ukoumunne; John L. Campbell
Diabetes Care May 2014, Vol.37, 1613-1620. doi:https://doi.org/10.2337/dc13-1576
Understanding the High Prevalence of Diabetes in U.S. South Asians Compared With Four Racial/Ethnic Groups: The MASALA and MESA Studies
Alka M. Kanaya; David Herrington; Eric Vittinghoff; Susan K. Ewing; Kiang Liu; Michael J. Blaha; Swapna S. Dave; Fareeha Qureshi; Namratha R. Kandula
Diabetes Care May 2014, Vol.37, 1621-1628. doi:https://doi.org/10.2337/dc13-2656
Changes Over Time in High Out-of-Pocket Health Care Burden in U.S. Adults With Diabetes, 2001–2011
Rui Li; Lawrence E. Barker; Sundar Shrestha; Ping Zhang; O. Kenrick Duru; Tony Pearson-Clarke; Edward W. Gregg
Diabetes Care May 2014, Vol.37, 1629-1635. doi:https://doi.org/10.2337/dc13-1997
Diabetes and Vascular Disease in Different Arterial Territories
Binita Shah; Caron B. Rockman; Yu Guo; Jaclyn Chesner; Arthur Z. Schwartzbard; Howard S. Weintraub; Mark A. Adelman; Thomas S. Riles; Jeffrey S. Berger
Diabetes Care May 2014, Vol.37, 1636-1642. doi:https://doi.org/10.2337/dc13-2432
LADA and CARDS: A Prospective Study of Clinical Outcome in Established Adult-Onset Autoimmune Diabetes
Mohammed Iqbal Hawa; Ana Paula Buchan; Thomas Ola; Chuan Chuan Wun; David A. DeMicco; Weihang Bao; D. John Betteridge; Paul N. Durrington; John H. Fuller; H. Andrew W. Neil; Helen Colhoun; Richard David Leslie; Graham A. Hitman
Diabetes Care May 2014, Vol.37, 1643-1649. doi:https://doi.org/10.2337/dc13-2383
Emerging Technologies and Therapeutics
Empagliflozin as Add-On to Metformin in Patients With Type 2 Diabetes: A 24-Week, Randomized, Double-Blind, Placebo-Controlled Trial
Hans-Ulrich Häring; Ludwig Merker; Elke Seewaldt-Becker; Marc Weimer; Thomas Meinicke; Uli C. Broedl; Hans J. Woerle; on behalf of the EMPA-REG MET Trial Investigators
Diabetes Care May 2014, Vol.37, 1650-1659. doi:https://doi.org/10.2337/dc13-2105
Pathophysiology / Complications
Improved Survival and Renal Prognosis of Patients With Type 2 Diabetes and Nephropathy With Improved Control of Risk Factors
Gudbjörg Andrésdóttir; Majken L. Jensen; Bendix Carstensen; Hans-Henrik Parving; Kasper Rossing; Tine W. Hansen; Peter Rossing
Diabetes Care May 2014, Vol.37, 1660-1667. doi:https://doi.org/10.2337/dc13-2036
Estimating the Delay Between Onset and Diagnosis of Type 2 Diabetes From the Time Course of Retinopathy Prevalence
Massimo Porta; Giulia Curletto; Dario Cipullo; Roberta Rigault de la Longrais; Marina Trento; Pietro Passera; Anna Viola Taulaigo; Sabrina Di Miceli; Antonella Cenci; Paola Dalmasso; Franco Cavallo
Diabetes Care May 2014, Vol.37, 1668-1674. doi:https://doi.org/10.2337/dc13-2101
GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial
Stephanie Krause; Ulrike Landherr; Carl-David Agardh; Simone Hausmann; Katarina Link; Jesse M. Hansen; Kristian F. Lynch; Michael Powell; Jadwiga Furmaniak; Bernard Rees-Smith; Ezio Bonifacio; Anette G. Ziegler; Åke Lernmark; Peter Achenbach
Diabetes Care May 2014, Vol.37, 1675-1680. doi:https://doi.org/10.2337/dc13-1719
Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy
Dinesh Selvarajah; Iain D. Wilkinson; Michael Maxwell; Jennifer Davies; Adhithya Sankar; Elaine Boland; Rajiv Gandhi; Irene Tracey; Solomon Tesfaye
Diabetes Care May 2014, Vol.37, 1681-1688. doi:https://doi.org/10.2337/dc13-2610
Aberrant Brain Functional Connectivity Related to Insulin Resistance in Type 2 Diabetes: A Resting-State fMRI Study
Yu-Chen Chen; Yun Jiao; Ying Cui; Song-An Shang; Jie Ding; Yuan Feng; Wen Song; Sheng-Hong Ju; Gao-Jun Teng
Diabetes Care May 2014, Vol.37, 1689-1696. doi:https://doi.org/10.2337/dc13-2127
Risk Factors for Plantar Foot Ulcer Recurrence in Neuropathic Diabetic Patients
Roelof Waaijman; Mirjam de Haart; Mark L.J. Arts; Daniel Wever; Anke J.W.E. Verlouw; Frans Nollet; Sicco A. Bus
Diabetes Care May 2014, Vol.37, 1697-1705. doi:https://doi.org/10.2337/dc13-2470
Baseline Adiponectin Levels Do Not Influence the Response to Pioglitazone in ACT NOW
Devjit Tripathy; Stephen C. Clement; Dawn C. Schwenke; MaryAnn Banerji; George A. Bray; Thomas A. Buchanan; Amalia Gastaldelli; Robert R. Henry; Abbas E. Kitabchi; Sunder Mudaliar; Robert E. Ratner; Frankie B. Stentz; Nicolas Musi; Peter D. Reaven; Ralph A. DeFronzo
Diabetes Care May 2014, Vol.37, 1706-1711. doi:https://doi.org/10.2337/dc13-1745
Cardiovascular and Metabolic Risk
Healthy Behavior Change and Cardiovascular Outcomes in Newly Diagnosed Type 2 Diabetic Patients: A Cohort Analysis of the ADDITION-Cambridge Study
Diabetes Care May 2014, Vol.37, 1712-1720. doi:https://doi.org/10.2337/dc13-1731
Outcomes of Combined Cardiovascular Risk Factor Management Strategies in Type 2 Diabetes: The ACCORD Randomized Trial
Karen L. Margolis; Patrick J. O’Connor; Timothy M. Morgan; John B. Buse; Robert M. Cohen; William C. Cushman; Jeffrey A. Cutler; Gregory W. Evans; Hertzel C. Gerstein; Richard H. Grimm, Jr.; Edward W. Lipkin; K.M.Venkat Narayan; Matthew C. Riddle, Jr.; Ajay Sood; David C. Goff, Jr.
Diabetes Care May 2014, Vol.37, 1721-1728. doi:https://doi.org/10.2337/dc13-2334
Nonalcoholic Fatty Liver Disease Is Independently Associated With an Increased Incidence of Chronic Kidney Disease in Patients With Type 1 Diabetes
Giovanni Targher; Alessandro Mantovani; Isabella Pichiri; Lucia Mingolla; Valentina Cavalieri; William Mantovani; Serena Pancheri; Maddalena Trombetta; Giacomo Zoppini; Michel Chonchol; Christopher D. Byrne; Enzo Bonora
Diabetes Care May 2014, Vol.37, 1729-1736. doi:https://doi.org/10.2337/dc13-2704
Novel Communications in Diabetes
Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function
Richard A. Oram; Augustin M. Brooks; Shareen Forbes; Stephanie Eckoldt; Richard M. Smith; Pratik Choudhary; Miranda J. Rosenthal; Paul Johnson; Martin K. Rutter; Keith A. Burling; Timothy J. McDonald; James A.M. Shaw; Andrew T. Hattersley
Diabetes Care May 2014, Vol.37, 1737-1740. doi:https://doi.org/10.2337/dc13-1266
Evolution of Abnormal Plasma Glucagon Responses to Mixed-Meal Feedings in Youth With Type 1 Diabetes During the First 2 Years After Diagnosis
Jennifer Sherr; Eva Tsalikian; Larry Fox; Bruce Buckingham; Stuart Weinzimer; William V. Tamborlane; Neil H. White; Ana Maria Arbelaez; Craig Kollman; Katrina J. Ruedy; Peiyao Cheng; Roy W. Beck; for the Diabetes Research in Children Network (DirecNet)
Diabetes Care May 2014, Vol.37, 1741-1744. doi:https://doi.org/10.2337/dc13-2612
Scientific Statement
Evolution of “The Guideline Advantage”: Lessons Learned From the Front Lines of Outpatient Performance Measurement
Vincent Bufalino, MD; Mary Ann Bauman, MD; Jay H. Shubrook, DO; Alan J. Balch, PhD; Christopher Boone, MHA; Katy Vennum, MPH; Sarah Bradley; Richard C. Wender, MD; Regan Minners; Donna Arnett, PhD; on behalf of the American Cancer Society, American Diabetes Association; American Heart Association
Diabetes Care May 2014, Vol.37, 1745-1750. doi:https://doi.org/10.2337/dc14-0901
Consensus Report
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
Philippe A. Halban; Kenneth S. Polonsky; Donald W. Bowden; Meredith A. Hawkins; Charlotte Ling; Kieren J. Mather; Alvin C. Powers; Christopher J. Rhodes; Lori Sussel; Gordon C. Weir
Diabetes Care May 2014, Vol.37, 1751-1758. doi:https://doi.org/10.2337/dc14-0396
Meta-analysis
Computer-Based Interventions to Improve Self-management in Adults With Type 2 Diabetes: A Systematic Review and Meta-analysis
Kingshuk Pal; Sophie V. Eastwood; Susan Michie; Andrew Farmer; Maria L. Barnard; Richard Peacock; Bindie Wood; Phil Edwards; Elizabeth Murray
Diabetes Care May 2014, Vol.37, 1759-1766. doi:https://doi.org/10.2337/dc13-1386
Point-Counterpoint
Insulin Analogs—Are They Worth It? Yes!
Diabetes Care May 2014, Vol.37, 1767-1770. doi:https://doi.org/10.2337/dc14-0031
Insulin Analogs—Is There a Compelling Case to Use Them? No!
Diabetes Care May 2014, Vol.37, 1771-1774. doi:https://doi.org/10.2337/dc13-2915
Errata
Diabetes Prevention in the Real World: Effectiveness of Pragmatic Lifestyle Interventions for the Prevention of Type 2 Diabetes and of the Impact of Adherence to Guideline Recommendations: A Systematic Review and Meta-analysis. Diabetes Care 2014;37:922–933
Alison J. Dunkley; Danielle H. Bodicoat; Colin J. Greaves; Claire Russell; Thomas Yates; Melanie J. Davies; Kamlesh Khunti
Diabetes Care May 2014, Vol.37, 1775-1776. doi:https://doi.org/10.2337/dc14-er06
Issues and Events
E-Letters: Observations
Pharmacokinetics of Insulin Aspart in Pregnant Women With Type 1 Diabetes: Every Day Is Different
Diabetes Care May 2014, Vol.37, e121-e122. doi:https://doi.org/10.2337/dc13-2535
Patient With iDEND Syndrome–Related Mutation
Ana M. Prado-Carro; Joan Calzada-Hernández; Silvia Marín; Roque Cardona-Hernandez; Josep Oriola; Marta Nicolás; Marta Ramon-Krauel
Diabetes Care May 2014, Vol.37, e123-e124. doi:https://doi.org/10.2337/dc13-2877
Youth Repeatedly Hospitalized for DKA: Proof of Concept for Novel Interventions in Children’s Healthcare (NICH)
Diabetes Care May 2014, Vol.37, e125-e126. doi:https://doi.org/10.2337/dc13-2232
Optimizing Insulin Absorption and Insulin Injection Technique in Older Adults
Diabetes Care May 2014, Vol.37, e127-e128. doi:https://doi.org/10.2337/dc14-0086
Diabetic Charcot Neuroarthropathy of the Knee: Conservative Treatment Options as Alternatives to Surgery: Case Reports of Three Patients
Diabetes Care May 2014, Vol.37, e129-e130. doi:https://doi.org/10.2337/dc13-3045
Association Between Serum Total Bilirubin Levels and the Morphology of Corneal Nerve Fibers in Japanese Patients With Uncontrolled Type 2 Diabetes
Diabetes Care May 2014, Vol.37, e131-e132. doi:https://doi.org/10.2337/dc14-0027
Membership in a Diabetes Care Network Improves General Practitioners’ Practices for HbA1c and Microalbuminuria Monitoring: A Cohort Study Among Patients With Type 2 Diabetes
Ludovic Casanova; Aurélie Bocquier; Sébastien Cortaredona; Stève Nauleau; Laurent Sauze; Vincent Sciortino; Patrick Villani; Pierre Verger
Diabetes Care May 2014, Vol.37, e133-e134. doi:https://doi.org/10.2337/dc13-2883
Diagnostic Confusion? Repeat HbA1c for the Diagnosis of Diabetes
Diabetes Care May 2014, Vol.37, e135-e136. doi:https://doi.org/10.2337/dc14-0055
Need for Reclassification of Diabetes Secondary to Iron Overload in the ADA and WHO Classifications
Diabetes Care May 2014, Vol.37, e137-e138. doi:https://doi.org/10.2337/dc14-0119
Preventive Measures for Patients at Risk for Amputation From Diabetes and Peripheral Arterial Disease
Philip P. Goodney; Asha McClurg; Emily L. Spangler; Benjamin S. Brooke; Randall R. DeMartino; David H. Stone; Brian W. Nolan
Diabetes Care May 2014, Vol.37, e139-e140. doi:https://doi.org/10.2337/dc14-0034
Improvement of Electrophysiological Neuropathy After Islet Transplantation for Type 1 Diabetes: A 5-Year Prospective Study
Marie-Christine Vantyghem; Delphine Quintin; Robert Caiazzo; Clara Leroy; Violeta Raverdy; François Cassim; François Glowacki; Thomas Hubert; Valery Gmyr; Christian Noel; Julie Kerr-Conte; François Pattou
Diabetes Care May 2014, Vol.37, e141-e142. doi:https://doi.org/10.2337/dc14-0320
E-Letters: Comments and Responses
Response to Comment on Schmitz et al. Recurrent Subthreshold Depression in Type 2 Diabetes: An Important Risk Factor for Poor Health Outcomes. Diabetes Care 2014;37:970–978
Norbert Schmitz; Geneviève Gariépy; Kimberley J. Smith; Matthew Clyde; Ashok Malla; Richard Boyer; Irene Strychar; Alain Lesage; JianLi Wang
Diabetes Care May 2014, Vol.37, e146-e147. doi:https://doi.org/10.2337/dc14-0435
Comment on Pepino et al. Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load. Diabetes Care 2013;36:2530–2535
Diabetes Care May 2014, Vol.37, e148. doi:https://doi.org/10.2337/dc13-2972
Response to Comment on Moore et al. Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin. Diabetes Care 2013;36:2981–2987
Eileen M. Moore; Alastair G. Mander; David Ames; Mark A. Kotowicz; Ross P. Carne; Henry Brodaty; Michael Woodward; Kathryn A. Ellis; Ashley I. Bush; Noel G. Faux; David A. Watters
Diabetes Care May 2014, Vol.37, e151. doi:https://doi.org/10.2337/dc14-0278
Comment on Hillis et al. The Relative and Combined Ability of High-Sensitivity Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Predict Cardiovascular Events and Death in Patients With Type 2 Diabetes. Diabetes Care 2014;37:295–303
Diabetes Care May 2014, Vol.37, e152-e153. doi:https://doi.org/10.2337/dc14-0052
Response to Comment on Hillis et al. The Relative and Combined Ability of High-Sensitivity Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Predict Cardiovascular Events and Death in Patients With Type 2 Diabetes. Diabetes Care 2014;37:295–303
Diabetes Care May 2014, Vol.37, e154. doi:https://doi.org/10.2337/dc14-0485
Comment on Lecoultre et al. Ten Nights of Moderate Hypoxia Improves Insulin Sensitivity in Obese Humans. Diabetes Care 2013;36:e197–e198
Diabetes Care May 2014, Vol.37, e155-e156. doi:https://doi.org/10.2337/dc14-0097
Response to Comment on Lecoultre et al. Ten Nights of Moderate Hypoxia Improves Insulin Sensitivity in Obese Humans. Diabetes Care 2013;36:e197–e198
Diabetes Care May 2014, Vol.37, e157-e158. doi:https://doi.org/10.2337/dc14-0620