Skip Nav Destination
Issues
1 November 2016
-
Cover Image
Cover Image
Cover: Conceptual image of a molecular model of a strand of DNA being held on a human hand. Credit: Victor de Schwanberg/Science Source. For more information, please visit sciencesource.com. This issue of Diabetes Care includes a special article collection “Emerging Science, Concepts, and Approach to Precision Medicine” (pp. 1854–1924).
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0149-5992
EISSN 1935-5548
In this Issue
In This Issue
In This Issue of Diabetes Care
Diabetes Care October 2016, Vol.39, 1849-1850. doi:https://doi.org/10.2337/dc16-ti11
Commentary
Identifying Causes for Excess Mortality in Patients With Diabetes: Closer but Not There Yet
Diabetes Care October 2016, Vol.39, 1851-1853. doi:https://doi.org/10.2337/dci16-0026
Emerging Science, Concepts, and Approach to Precision Medicine
The Impact of Precision Medicine in Diabetes: A Multidimensional Perspective
Diabetes Care October 2016, Vol.39, 1854-1857. doi:https://doi.org/10.2337/dc16-1833
The Application of Genomics in Diabetes: Barriers to Discovery and Implementation
Diabetes Care October 2016, Vol.39, 1858-1869. doi:https://doi.org/10.2337/dc16-0738
Precision Medicine, Genomics, and Public Health
Diabetes Care October 2016, Vol.39, 1870-1873. doi:https://doi.org/10.2337/dc16-1763
Precision Medicine, Diabetes, and the U.S. Food and Drug Administration
Diabetes Care October 2016, Vol.39, 1874-1878. doi:https://doi.org/10.2337/dc16-1762
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes
Maggie Shepherd; on behalf of the UNITED Team; Beverley Shields; on behalf of the UNITED Team; Suzanne Hammersley; on behalf of the UNITED Team; Michelle Hudson; on behalf of the UNITED Team; Timothy J. McDonald; on behalf of the UNITED Team; Kevin Colclough; on behalf of the UNITED Team; Richard A. Oram; on behalf of the UNITED Team; Bridget Knight; on behalf of the UNITED Team; Christopher Hyde; on behalf of the UNITED Team; Julian Cox; on behalf of the UNITED Team; Katherine Mallam; on behalf of the UNITED Team; Christopher Moudiotis; on behalf of the UNITED Team; Rebecca Smith; on behalf of the UNITED Team; Barbara Fraser; on behalf of the UNITED Team; Simon Robertson; on behalf of the UNITED Team; Stephen Greene; on behalf of the UNITED Team; Sian Ellard; on behalf of the UNITED Team; Ewan R. Pearson; on behalf of the UNITED Team; Andrew T. Hattersley; on behalf of the UNITED Team
Diabetes Care June 2016, Vol.39, 1879-1888. doi:https://doi.org/10.2337/dc16-0645
Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes
Despoina Manousaki; Jack W. Kent, Jr.; Karin Haack; Sirui Zhou; Pingxing Xie; Celia M. Greenwood; Paul Brassard; Deborah E. Newman; Shelley Cole; Jason G. Umans; Guy Rouleau; Anthony G. Comuzzie; J. Brent Richards
Diabetes Care August 2016, Vol.39, 1889-1895. doi:https://doi.org/10.2337/dc16-0769
Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study
Diabetes Care August 2016, Vol.39, 1896-1901. doi:https://doi.org/10.2337/dc16-0706
CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes
Adem Y. Dawed; Louise Donnelly; Roger Tavendale; Fiona Carr; Graham Leese; Colin N.A. Palmer; Ewan R. Pearson; Kaixin Zhou
Diabetes Care June 2016, Vol.39, 1902-1908. doi:https://doi.org/10.2337/dc15-2464
Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial
Yoriko Heianza; Wenjie Ma; Tao Huang; Tiange Wang; Yan Zheng; Steven R. Smith; George A. Bray; Frank M. Sacks; Lu Qi
Diabetes Care August 2016, Vol.39, 1909-1914. doi:https://doi.org/10.2337/dc16-1111
Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial
Hetal S. Shah; He Gao; Mario Luca Morieri; Jan Skupien; Skylar Marvel; Guillaume Paré; Gaia C. Mannino; Patinut Buranasupkajorn; Christine Mendonca; Timothy Hastings; Santica M. Marcovina; Ronald J. Sigal; Hertzel C. Gerstein; Michael J. Wagner; Alison A. Motsinger-Reif; John B. Buse; Peter Kraft; Josyf C. Mychaleckyj; Alessandro Doria
Diabetes Care August 2016, Vol.39, 1915-1924. doi:https://doi.org/10.2337/dc16-0285
Clinical Care / Education / Nutrition / Psychosocial Research
Short-term Effects of Laparoscopic Adjustable Gastric Banding Versus Roux-en-Y Gastric Bypass
Amalia Gastaldelli; Amerigo Iaconelli; Melania Gaggini; Maria Chiara Magnone; Augusto Veneziani; Francesco Rubino; Geltrude Mingrone
Diabetes Care August 2016, Vol.39, 1925-1931. doi:https://doi.org/10.2337/dc15-2823
Inverse Relationship Between Organ-Specific Autoantibodies and Systemic Immune Mediators in Type 1 Diabetes and Type 2 Diabetes: Action LADA 11
Nanette C. Schloot; Minh N. Pham; Mohammed I. Hawa; Paolo Pozzilli; Werner A. Scherbaum; Matthias Schott; Hubert Kolb; Steven Hunter; Guntram Schernthaner; Charles Thivolet; Jochen Seissler; Richard David Leslie; for the Action LADA Group
Diabetes Care August 2016, Vol.39, 1932-1939. doi:https://doi.org/10.2337/dc16-0293
Increased Risk of Incident Chronic Kidney Disease, Cardiovascular Disease, and Mortality in Patients With Diabetes With Comorbid Depression
Marta Novak; Istvan Mucsi; Connie M. Rhee; Elani Streja; Jun L. Lu; Kamyar Kalantar-Zadeh; Miklos Z. Molnar; Csaba P. Kovesdy
Diabetes Care June 2016, Vol.39, 1940-1947. doi:https://doi.org/10.2337/dc16-0048
Randomized Controlled Study of Metformin and Sitagliptin on Long-term Normoglycemia Remission in African American Patients With Hyperglycemic Crises
Priyathama Vellanki; Dawn D. Smiley; Darko Stefanovski; Isabel Anzola; Wenlan Duan; Megan Hudson; Limin Peng; Francisco J. Pasquel; Guillermo E. Umpierrez
Diabetes Care August 2016, Vol.39, 1948-1955. doi:https://doi.org/10.2337/dc16-0406
Correlates of Medication Adherence in the TODAY Cohort of Youth With Type 2 Diabetes
Lorraine Levitt Katz; Barbara J. Anderson; Siripoom V. McKay; Roberto Izquierdo; Terri L. Casey; Laurie A. Higgins; Aimee Wauters; Kathryn Hirst; Kristen J. Nadeau; for the TODAY Study Group
Diabetes Care June 2016, Vol.39, 1956-1962. doi:https://doi.org/10.2337/dc15-2296
Kindness Matters: A Randomized Controlled Trial of a Mindful Self-Compassion Intervention Improves Depression, Distress, and HbA1c Among Patients With Diabetes
Diabetes Care June 2016, Vol.39, 1963-1971. doi:https://doi.org/10.2337/dc16-0416
Efficacy and Safety of LixiLan, a Titratable Fixed-Ratio Combination of Insulin Glargine Plus Lixisenatide in Type 2 Diabetes Inadequately Controlled on Basal Insulin and Metformin: The LixiLan-L Randomized Trial
Vanita R. Aroda; Julio Rosenstock; Carol Wysham; Jeffrey Unger; Diego Bellido; Guillermo González-Gálvez; Akane Takami; Hailing Guo; Elisabeth Niemoeller; Elisabeth Souhami; Richard M. Bergenstal; on behalf of the LixiLan-L Trial Investigators
Diabetes Care September 2016, Vol.39, 1972-1980. doi:https://doi.org/10.2337/dc16-1495
Epidemiology / Health Services Research
Medical Care Costs Associated With Long-term Weight Maintenance Versus Weight Gain Among Patients With Type 2 Diabetes
Diabetes Care August 2016, Vol.39, 1981-1986. doi:https://doi.org/10.2337/dc16-0933
Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis
Jose Miguel Baena-Díez; Judit Peñafiel; Isaac Subirana; Rafel Ramos; Roberto Elosua; Alejandro Marín-Ibañez; María Jesús Guembe; Fernando Rigo; María José Tormo-Díaz; Conchi Moreno-Iribas; Joan Josep Cabré; Antonio Segura; Manel García-Lareo; Agustín Gómez de la Cámara; José Lapetra; Miquel Quesada; Jaume Marrugat; Maria José Medrano; Jesús Berjón; Guiem Frontera; Diana Gavrila; Aurelio Barricarte; Josep Basora; Jose María García; Natalia C. Pavone; David Lora-Pablos; Eduardo Mayoral; Josep Franch; Manel Mata; Conxa Castell; Albert Frances; María Grau; on behalf of the FRESCO Investigators
Diabetes Care August 2016, Vol.39, 1987-1995. doi:https://doi.org/10.2337/dc16-0614
BMI at Age 17 Years and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents
Gilad Twig; Amir Tirosh; Adi Leiba; Hagai Levine; Dana Ben-Ami Shor; Estela Derazne; Ziona Haklai; Nehama Goldberger; Michal Kasher-Meron; Dror Yifrach; Hertzel C. Gerstein; Jeremy D. Kark
Diabetes Care October 2016, Vol.39, 1996-2003. doi:https://doi.org/10.2337/dc16-1203
Long-term Effect of Losartan on Kidney Disease in American Indians With Type 2 Diabetes: A Follow-up Analysis of a Randomized Clinical Trial
Stephanie K. Tanamas; Pierre-Jean Saulnier; Gudeta D. Fufaa; Kevin M. Wheelock; E. Jennifer Weil; Robert L. Hanson; William C. Knowler; Peter H. Bennett; Robert G. Nelson
Diabetes Care September 2016, Vol.39, 2004-2010. doi:https://doi.org/10.2337/dc16-0795
Changes in Overall Diet Quality and Subsequent Type 2 Diabetes Risk: Three U.S. Prospective Cohorts
Diabetes Care September 2016, Vol.39, 2011-2018. doi:https://doi.org/10.2337/dc16-0574
Emerging Technologies and Therapeutics
Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Suboptimally Controlled Adolescents With Type 1 Diabetes: A 3-Week, Free-Living, Randomized Crossover Trial
Martin Tauschmann; Janet M. Allen; Malgorzata E. Wilinska; Hood Thabit; Carlo L. Acerini; David B. Dunger; Roman Hovorka
Diabetes Care September 2016, Vol.39, 2019-2025. doi:https://doi.org/10.2337/dc16-1094
Benefits of LixiLan, a Titratable Fixed-Ratio Combination of Insulin Glargine Plus Lixisenatide, Versus Insulin Glargine and Lixisenatide Monocomponents in Type 2 Diabetes Inadequately Controlled on Oral Agents: The LixiLan-O Randomized Trial
Julio Rosenstock; Ronnie Aronson; George Grunberger; Markolf Hanefeld; PierMarco Piatti; Pierre Serusclat; Xi Cheng; Tianyue Zhou; Elisabeth Niemoeller; Elisabeth Souhami; Melanie Davies; on behalf of the LixiLan-O Trial Investigators
Diabetes Care August 2016, Vol.39, 2026-2035. doi:https://doi.org/10.2337/dc16-0917
Pathophysiology / Complications
Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 Diabetes
Giuseppe Daniele; Juan Xiong; Carolina Solis-Herrera; Aurora Merovci; Roy Eldor; Devjit Tripathy; Ralph A. DeFronzo; Luke Norton; Muhammad Abdul-Ghani
Diabetes Care August 2016, Vol.39, 2036-2041. doi:https://doi.org/10.2337/dc15-2688
Renal Effects of DPP-4 Inhibitor Sitagliptin or GLP-1 Receptor Agonist Liraglutide in Overweight Patients With Type 2 Diabetes: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
Lennart Tonneijck; Mark M. Smits; Marcel H.A. Muskiet; Trynke Hoekstra; Mark H.H. Kramer; A.H. Jan Danser; Piet M. ter Wee; Michaela Diamant; Jaap A. Joles; Daniël H. van Raalte
Diabetes Care September 2016, Vol.39, 2042-2050. doi:https://doi.org/10.2337/dc16-1371
Hispanics/Latinos With Type 2 Diabetes Have Functional and Symptomatic Pulmonary Impairment Mirroring Kidney Microangiopathy: Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Oana L. Klein; Larissa Aviles-Santa; Jianwen Cai; Harold R. Collard; Alka M. Kanaya; Robert C. Kaplan; Gregory L. Kinney; Eliana Mendes; Lewis Smith; Gregory Talavera; Donghong Wu; Martha Daviglus
Diabetes Care September 2016, Vol.39, 2051-2057. doi:https://doi.org/10.2337/dc16-1170
Cardiovascular and Metabolic Risk
Diabetes Is Associated With Decreased Limb Survival in Patients With Critical Limb Ischemia: Pooled Data From Two Randomized Controlled Trials
Marlon I. Spreen; Hendrik Gremmels; Martin Teraa; Ralf W. Sprengers; Marianne C. Verhaar; Randolph G. Statius van Eps; Jean-Paul P.M. de Vries; Willem P.Th.M. Mali; Hans van Overhagen; on behalf of the PADI and JUVENTAS Study Groups
Diabetes Care September 2016, Vol.39, 2058-2064. doi:https://doi.org/10.2337/dc16-0850
Position Statement
Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association
Sheri R. Colberg; Ronald J. Sigal; Jane E. Yardley; Michael C. Riddell; David W. Dunstan; Paddy C. Dempsey; Edward S. Horton; Kristin Castorino; Deborah F. Tate
Diabetes Care October 2016, Vol.39, 2065-2079. doi:https://doi.org/10.2337/dc16-1728
Review
Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction
Diabetes Care October 2016, Vol.39, 2080-2088. doi:https://doi.org/10.2337/dc16-0619
Meta-analysis
Do Mobile Phone Applications Improve Glycemic Control (HbA1c) in the Self-management of Diabetes? A Systematic Review, Meta-analysis, and GRADE of 14 Randomized Trials
Diabetes Care October 2016, Vol.39, 2089-2095. doi:https://doi.org/10.2337/dc16-0346
Erratum
Erratum. Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A Meta-analysis From 1990–2010. Diabetes Care 2016;39:1643–1649
Janet L. Leasher; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Rupert R.A. Bourne; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Seth R. Flaxman; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Jost B. Jonas; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Jill Keeffe; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Novin Naidoo; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Konrad Pesudovs; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Holly Price; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Richard A. White; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Tien Y. Wong; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Serge Resnikoff; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study; Hugh R. Taylor; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study
Diabetes Care October 2016, Vol.39, 2096. doi:https://doi.org/10.2337/dc16-er11
Issues and Events
e-Letters
Comments and Responses
Comment on Ferrannini et al. Diabetes Care 2016;39:1108–1114. Comment on Mudaliar et al. Diabetes Care 2016;39:1115–1122
Diabetes Care October 2016, Vol.39, e195. doi:https://doi.org/10.2337/dc16-1332
Response to Comment on Ferrannini et al. Diabetes Care 2016;39:1108–1114. Comment on Mudaliar et al. Diabetes Care 2016;39:1115–1122
Diabetes Care October 2016, Vol.39, e196-e197. doi:https://doi.org/10.2337/dci16-0027
Response to Comment on Kazda et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care 2016;39:1241–1249
Christof M. Kazda; Ying Ding; Ronan P. Kelly; Parag Garhyan; Chunxue Shi; Chay Ngee Lim; Haoda Fu; David E. Watson; Andrew J. Lewin; William H. Landschulz; Mark A. Deeg; David E. Moller; Thomas A. Hardy
Diabetes Care October 2016, Vol.39, e199-e200. doi:https://doi.org/10.2337/dci16-0030
Comment on Qian et al. Metabolic Effects of Monounsaturated Fatty Acid–Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid–Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2016;39:1448–1457
Diabetes Care October 2016, Vol.39, e204. doi:https://doi.org/10.2337/dc16-1613
Response to Comment on Qian et al. Metabolic Effects of Monounsaturated Fatty Acid–Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid–Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diabetes Care 2016;39:1448–1457
Diabetes Care October 2016, Vol.39, e205. doi:https://doi.org/10.2337/dci16-0034
Comment on Fischer et al. Text Message Support for Weight Loss in Patients With Prediabetes: A Randomized Clinical Trial. Diabetes Care 2016;39:1364–1370
Diabetes Care October 2016, Vol.39, e206. doi:https://doi.org/10.2337/dc16-1210
Response to Comment on Fischer et al. Text Message Support for Weight Loss in Patients With Prediabetes: A Randomized Clinical Trial. Diabetes Care 2016;39:1364–1370
Henry H. Fischer; Rocio I. Pereira; Susan L. Moore; Michael J. Durfee; Jeanne M. Rozwadowski; Edward P. Havranek
Diabetes Care October 2016, Vol.39, e207-e208. doi:https://doi.org/10.2337/dci16-0024
