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1 September 2016
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ISSN 0149-5992
EISSN 1935-5548
In this Issue
In This Issue
In This Issue of Diabetes Care
Diabetes Care August 2016, Vol.39, 1479-1480. doi:https://doi.org/10.2337/dc16-ti09
Profiles in Progress
George A. Bray, MD: Progress in Obesity—Multidisciplinary Research, Multidimensional Man
Diabetes Care August 2016, Vol.39, 1481-1485. doi:https://doi.org/10.2337/dc16-1375
Clinical Care / Education / Nutrition / Psychosocial Research
Insulin Injection Into Lipohypertrophic Tissue: Blunted and More Variable Insulin Absorption and Action and Impaired Postprandial Glucose Control
Susanne Famulla; Ulrike Hövelmann; Annelie Fischer; Hans-Veit Coester; Lidia Hermanski; Matthias Kaltheuner; Lars Kaltheuner; Lutz Heinemann; Tim Heise; Laurence Hirsch
Diabetes Care July 2016, Vol.39, 1486-1492. doi:https://doi.org/10.2337/dc16-0610
Transdermal Buprenorphine Relieves Neuropathic Pain: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial in Diabetic Peripheral Neuropathic Pain
Diabetes Care June 2016, Vol.39, 1493-1500. doi:https://doi.org/10.2337/dc16-0123
Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial
Michael Nauck; Manfredi Rizzo; Andrew Johnson; Heidrun Bosch-Traberg; Jesper Madsen; Bertrand Cariou
Diabetes Care June 2016, Vol.39, 1501-1509. doi:https://doi.org/10.2337/dc15-2479
Durability of Addition of Roux-en-Y Gastric Bypass to Lifestyle Intervention and Medical Management in Achieving Primary Treatment Goals for Uncontrolled Type 2 Diabetes in Mild to Moderate Obesity: A Randomized Control Trial
Sayeed Ikramuddin; Judith Korner; Wei-Jei Lee; John P. Bantle; Avis J. Thomas; John E. Connett; Daniel B. Leslie; William B. Inabnet, III; Qi Wang; Robert W. Jeffery; Keong Chong; Lee-Ming Chuang; Michael D. Jensen; Adrian Vella; Leaque Ahmed; Kumar Belani; Amy E. Olofson; Heather A. Bainbridge; Charles J. Billington
Diabetes Care June 2016, Vol.39, 1510-1518. doi:https://doi.org/10.2337/dc15-2481
Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes
Emily K. Sims; Zunaira Chaudhry; Renecia Watkins; Farooq Syed; Janice Blum; Fangqian Ouyang; Susan M. Perkins; Raghavendra G. Mirmira; Jay Sosenko; Linda A. DiMeglio; Carmella Evans-Molina
Diabetes Care July 2016, Vol.39, 1519-1526. doi:https://doi.org/10.2337/dc15-2849
Intensification of Diabetes Therapy and Time Until A1C Goal Attainment Among Patients With Newly Diagnosed Type 2 Diabetes Who Fail Metformin Monotherapy Within a Large Integrated Health System
Kevin M. Pantalone; Brian J. Wells; Kevin M. Chagin; Flavia Ejzykowicz; Changhong Yu; Alex Milinovich; Janine M. Bauman; Michael W. Kattan; Swapnil Rajpathak; Robert S. Zimmerman
Diabetes Care August 2016, Vol.39, 1527-1534. doi:https://doi.org/10.2337/dc16-0227
Epidemiology / Health Services Research
Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study
Kendra Vehik; Kristian F. Lynch; Desmond A. Schatz; Beena Akolkar; William Hagopian; Marian Rewers; Jin-Xiong She; Olli Simell; Jorma Toppari; Anette-G. Ziegler; Åke Lernmark; Ezio Bonifacio; Jeffrey P. Krischer; the TEDDY Study Group
Diabetes Care June 2016, Vol.39, 1535-1542. doi:https://doi.org/10.2337/dc16-0181
Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study
Naoki Hirabayashi; Jun Hata; Tomoyuki Ohara; Naoko Mukai; Masaharu Nagata; Mao Shibata; Seiji Gotoh; Yoshihiko Furuta; Fumio Yamashita; Kazufumi Yoshihara; Takanari Kitazono; Nobuyuki Sudo; Yutaka Kiyohara; Toshiharu Ninomiya
Diabetes Care July 2016, Vol.39, 1543-1549. doi:https://doi.org/10.2337/dc15-2800
Changes in Mortality in People With IGT Before and After the Onset of Diabetes During the 23-Year Follow-up of the Da Qing Diabetes Prevention Study
Qiuhong Gong; Ping Zhang; Jinping Wang; Yali An; Edward W. Gregg; Hui Li; Bo Zhang; Ying Shuai; Wenying Yang; Yanyan Chen; Shuqian Liu; Michael M. Engelgau; Yinghua Hu; Peter H. Bennett; Guangwei Li
Diabetes Care July 2016, Vol.39, 1550-1555. doi:https://doi.org/10.2337/dc16-0429
Diagnosed and Undiagnosed Diabetes Prevalence by County in the U.S., 1999–2012
Diabetes Care August 2016, Vol.39, 1556-1562. doi:https://doi.org/10.2337/dc16-0678
Early Prediction of Developing Type 2 Diabetes by Plasma Acylcarnitines: A Population-Based Study
Liang Sun; Liming Liang; Xianfu Gao; Huiping Zhang; Pang Yao; Yao Hu; Yiwei Ma; Feijie Wang; Qianlu Jin; Huaixing Li; Rongxia Li; Yong Liu; Frank B. Hu; Rong Zeng; Xu Lin; Jiarui Wu
Diabetes Care July 2016, Vol.39, 1563-1570. doi:https://doi.org/10.2337/dc16-0232
A Population-Based Study of All-Cause Mortality and Cardiovascular Disease in Association With Prior History of Hypoglycemia Among Patients With Type 1 Diabetes
Diabetes Care July 2016, Vol.39, 1571-1578. doi:https://doi.org/10.2337/dc15-2418
Emerging Technologies and Therapeutics
Efficacy and Safety of LixiLan, a Titratable Fixed-Ratio Combination of Lixisenatide and Insulin Glargine, Versus Insulin Glargine in Type 2 Diabetes Inadequately Controlled on Metformin Monotherapy: The LixiLan Proof-of-Concept Randomized Trial
Julio Rosenstock; Michaela Diamant; Vanita R. Aroda; Louise Silvestre; Elisabeth Souhami; Tianyue Zhou; Riccardo Perfetti; Vivian Fonseca; for the LixiLan PoC Study Group
Diabetes Care June 2016, Vol.39, 1579-1586. doi:https://doi.org/10.2337/dc16-0046
Pathophysiology / Complications
Cardiovascular Autonomic Neuropathy, Sexual Dysfunction, and Urinary Incontinence in Women With Type 1 Diabetes
James M. Hotaling; Aruna V. Sarma; Darshan P. Patel; Barbara H. Braffett; Patricia A. Cleary; Eva Feldman; William H. Herman; Catherine L. Martin; Alan M. Jacobson; Hunter Wessells; Rodica Pop-Busui; for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes Care June 2016, Vol.39, 1587-1593. doi:https://doi.org/10.2337/dc16-0059
Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China
Tianpeng Zheng; Linyuan Qin; Bo Chen; Xueping Hu; Xiaoxi Zhang; Yihong Liu; Hongbo Liu; Shenghua Qin; Gang Li; Qinghua Li
Diabetes Care July 2016, Vol.39, 1594-1601. doi:https://doi.org/10.2337/dc16-0316
Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series
Sudha S. Shankar; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Adrian Vella; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Ralph H. Raymond; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Myrlene A. Staten; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Roberto A. Calle; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Richard N. Bergman; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Charlie Cao; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Danny Chen; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Claudio Cobelli; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Chiara Dalla Man; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Mark Deeg; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Jennifer Q. Dong; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Douglas S. Lee; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; David Polidori; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; R. Paul Robertson; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Hartmut Ruetten; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Darko Stefanovski; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Maria T. Vassileva; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; Gordon C. Weir; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team; David A. Fryburg; on behalf of the Foundation for the National Institutes of Health β-Cell Project Team
Diabetes Care July 2016, Vol.39, 1602-1613. doi:https://doi.org/10.2337/dc15-0931
Increased Burden of Cerebral Small Vessel Disease in Patients With Type 2 Diabetes and Retinopathy
Jordi Sanahuja; Núria Alonso; Javier Diez; Emilio Ortega; Esther Rubinat; Alícia Traveset; Núria Alcubierre; Àngels Betriu; Esmeralda Castelblanco; Marta Hernández; Francisco Purroy; Maria Vittoria Arcidiacono; Carmen Jurjo; Elvira Fernández; Manuel Puig-Domingo; Per-Henrik Groop; Dídac Mauricio
Diabetes Care June 2016, Vol.39, 1614-1620. doi:https://doi.org/10.2337/dc15-2671
Cardiovascular and Metabolic Risk
Coprogression of Cardiovascular Risk Factors in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study
Diabetes Care July 2016, Vol.39, 1621-1630. doi:https://doi.org/10.2337/dc16-0502
Novel Communications in Diabetes
Consensus Report
Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities
Kristen J. Nadeau; Barbara J. Anderson; Erika G. Berg; Jane L. Chiang; Hubert Chou; Kenneth C. Copeland; Tamara S. Hannon; Terry T.-K. Huang; Jane L. Lynch; Jeff Powell; Elizabeth Sellers; William V. Tamborlane; Philip Zeitler
Diabetes Care August 2016, Vol.39, 1635-1642. doi:https://doi.org/10.2337/dc16-1066
Meta-Analysis
Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A Meta-analysis From 1990 to 2010
Janet L. Leasher; Rupert R.A. Bourne; Seth R. Flaxman; Jost B. Jonas; Jill Keeffe; Kovin Naidoo; Konrad Pesudovs; Holly Price; Richard A. White; Tien Y. Wong; Serge Resnikoff; Hugh R. Taylor; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study
Diabetes Care August 2016, Vol.39, 1643-1649. doi:https://doi.org/10.2337/dc15-2171
Clinical Images in Diabetes
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes
Diabetes Care August 2016, Vol.39, 1650-1652. doi:https://doi.org/10.2337/dc16-0711
Erratum
Issues and Events
E-Letters: Observations
Carbohydrate Counting at Meal Time Followed by a Small Secondary Postprandial Bolus Injection at 3 Hours Prevents Late Hyperglycemia, Without Hypoglycemia, After a High-Carbohydrate, High-Fat Meal in Type 1 Diabetes
Matthew D. Campbell; Mark Walker; David King; Javier T. Gonzalez; Dean Allerton; Emma J. Stevenson; James A. Shaw; Daniel J. West
Diabetes Care June 2016, Vol.39, e141-e142. doi:https://doi.org/10.2337/dc16-0709
Primary Prevention of Sexual Dysfunction With Mediterranean Diet in Type 2 Diabetes: The MÈDITA Randomized Trial
Maria Ida Maiorino; Giuseppe Bellastella; Paolo Chiodini; Ornella Romano; Lorenzo Scappaticcio; Dario Giugliano; Katherine Esposito
Diabetes Care June 2016, Vol.39, e143-e144. doi:https://doi.org/10.2337/dc16-0910
Do Patient Characteristics Impact Decisions by Clinicians on Hemoglobin A1c Targets?
Diabetes Care June 2016, Vol.39, e145-e146. doi:https://doi.org/10.2337/dc16-0532
Secreted Frizzled-Related Protein 4 (SFRP4): A Novel Biomarker of β-Cell Dysfunction and Insulin Resistance in Individuals With Prediabetes and Type 2 Diabetes
Kaviya Anand; Sudha Vidyasagar; Ian Lasrado; Gautam Kumar Pandey; Anandakumar Amutha; Harish Ranjani; Ranjit Mohan Anjana; Viswanathan Mohan; Kuppan Gokulakrishnan
Diabetes Care July 2016, Vol.39, e147-e148. doi:https://doi.org/10.2337/dc16-0756
E-Letters: Comments and Responses
Comment on Podmore et al. Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study. Diabetes Care 2016;39:572–581
Diabetes Care August 2016, Vol.39, e149-e150. doi:https://doi.org/10.2337/dc16-0538
Comment on Muraki et al. Potato Consumption and Risk of Type 2 Diabetes: Results From Three Prospective Cohort Studies. Diabetes Care 2016;39:376–384
Diabetes Care August 2016, Vol.39, e151. doi:https://doi.org/10.2337/dc16-0434
Response to Comment on Kovatchev and Cobelli. Glucose Variability: Timing, Risk Analysis, and Relationship to Hypoglycemia in Diabetes. Diabetes Care 2016;39:502–510
Diabetes Care August 2016, Vol.39, e157-e158. doi:https://doi.org/10.2337/dci16-0019
Comment on Yang et al. Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation. Diabetes Care 2016;39:e54–e55
Joshua D. Fox; Katherine L. Baquerizo-Nole; Flor Macquhae; Ingrid Herskovitz; Jeremy B. Freedman; Loretta Vileikyte; David J. Margolis; Robert S. Kirsner
Diabetes Care August 2016, Vol.39, e159-e160. doi:https://doi.org/10.2337/dc16-0415
Response to Comment on Yang et al. Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation. Diabetes Care 2016;39:e54–e55
Tsung-Lin Yang; Liang-Yu Lin; Chin-Chou Huang; Po-Hsun Huang; Shing-Jong Lin; Jaw-Wen Chen; Wan-Leong Chan; Hsin-Bang Leu
Diabetes Care August 2016, Vol.39, e161-e162. doi:https://doi.org/10.2337/dci16-0013
