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Volume 42, Issue 2
February 2019
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ISSN 0149-5992
EISSN 1935-5548
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In This Issue

In This Issue of Diabetes Care
View articletitled, In This Issue of <em>Diabetes Care</em>
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Diabetes Care January 2019, Vol.42, 179-180. doi:https://doi.org/10.2337/dc19-ti02

Editor's Commentary

Diabetes Care in 2019—Who, Why, What, and How?
Matthew C. Riddle
View articletitled, <em>Diabetes Care</em> in 2019—Who, Why, What, and How?
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Diabetes Care January 2019, Vol.42, 181-182. doi:https://doi.org/10.2337/dci18-0059

Commentaries

Probing the Meaning of Persistent Propeptide Release in Type 1 Diabetes
Steven E. Kahn; Andrew T. Templin; Rebecca L. Hull; C. Bruce Verchere
View articletitled, Probing the Meaning of Persistent Propeptide Release in Type 1 Diabetes
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Diabetes Care January 2019, Vol.42, 183-185. doi:https://doi.org/10.2337/dci18-0054
Bariatric/Metabolic Surgery for Diabetes: Lessons From the Past and Present
Jonathan Q. Purnell; Bruce M. Wolfe
View articletitled, Bariatric/Metabolic Surgery for Diabetes: Lessons From the Past and Present
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Diabetes Care January 2019, Vol.42, 186-188. doi:https://doi.org/10.2337/dci18-0031

Predicting Diabetes Using Genetic Risk Scores

Genetics Coming of Age in Type 1 Diabetes
Karen Cerolsaletti; Wei Hao; Carla J. Greenbaum
View articletitled, Genetics Coming of Age in Type 1 Diabetes
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Diabetes Care January 2019, Vol.42, 189-191. doi:https://doi.org/10.2337/dci18-0039
Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes
Taylor M. Triolo; Alexandra Fouts; Laura Pyle; Liping Yu; Peter A. Gottlieb; Andrea K. Steck; Type 1 Diabetes TrialNet Study Group
View articletitled, Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes
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Diabetes Care July 2018, Vol.42, 192-199. doi:https://doi.org/10.2337/dc18-0288
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
Seth A. Sharp; Stephen S. Rich; Andrew R. Wood; Samuel E. Jones; Robin N. Beaumont; James W. Harrison; Darius A. Schneider; Jonathan M. Locke; Jess Tyrrell; Michael N. Weedon; William A. Hagopian; Richard A. Oram
View articletitled, Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
Supplementary data
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Diabetes Care January 2019, Vol.42, 200-207. doi:https://doi.org/10.2337/dc18-1785
A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy
Anita L. Grubb; Timothy J. McDonald; Femke Rutters; Louise A. Donnelly; Andrew T. Hattersley; Richard A. Oram; Colin N.A. Palmer; Amber A. van der Heijden; Fiona Carr; Petra J.M. Elders; Mike N. Weedon; Roderick C. Slieker; Leen M. ’t Hart; Ewan R. Pearson; Beverley M. Shields; Angus G. Jones
View articletitled, A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy
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Diabetes Care October 2018, Vol.42, 208-214. doi:https://doi.org/10.2337/dc18-0431
Cognitive, Neurological, and Behavioral Features in Adults With KCNJ11 Neonatal Diabetes
Pamela Bowman; Jacob Day; Lorna Torrens; Maggie H. Shepherd; Bridget A. Knight; Tamsin J. Ford; Sarah E. Flanagan; Ali Chakera; Andrew T. Hattersley; Adam Zeman
View articletitled, Cognitive, Neurological, and Behavioral Features in Adults With <em>KCNJ11</em> Neonatal Diabetes
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Diabetes Care October 2018, Vol.42, 215-224. doi:https://doi.org/10.2337/dc18-1060
Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes
Kashyap A. Patel; Michael N. Weedon; Beverley M. Shields; Ewan R. Pearson; Andrew T. Hattersley; Timothy J. McDonald; on behalf of the UNITED study team
View articletitled, Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes
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Diabetes Care November 2018, Vol.42, e16-e17. doi:https://doi.org/10.2337/dc18-0373

Clinical Care / Education / Nutrition / Psychosocial Research

Youth With Type 1 Diabetes Taking Responsibility for Self-Management: The Importance of Executive Functioning in Achieving Glycemic Control: Results From the Longitudinal DINO Study
Anne F. Vloemans; Minke M.A. Eilander; Joost Rotteveel; Willie M. Bakker-van Waarde; Euphemia C.A.M. Houdijk; Roos Nuboer; Per Winterdijk; Frank J. Snoek; Maartje De Wit
View articletitled, Youth With Type 1 Diabetes Taking Responsibility for Self-Management: The Importance of Executive Functioning in Achieving Glycemic Control<span class="subtitle-colon">: </span><span class="subtitle">Results From the Longitudinal DINO Study</span>
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Diabetes Care December 2018, Vol.42, 225-231. doi:https://doi.org/10.2337/dc18-1143

Epidemiology / Health Services Research

Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults
Anna Marseglia; Hui-Xin Wang; Debora Rizzuto; Laura Fratiglioni; Weili Xu
View articletitled, Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults
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Diabetes Care December 2018, Vol.42, 232-239. doi:https://doi.org/10.2337/dc18-1428
General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort
Sabrina Schlesinger; Christian Herder; Julia M. Kannenberg; Cornelia Huth; Maren Carstensen-Kirberg; Wolfgang Rathmann; Gidon J. Bönhof; Wolfgang Koenig; Margit Heier; Annette Peters; Christa Meisinger; Michael Roden; Barbara Thorand; Dan Ziegler
View articletitled, General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort
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Diabetes Care December 2018, Vol.42, 240-247. doi:https://doi.org/10.2337/dc18-1842

Emerging Technologies: Data Systems and Devices

Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset
John Virostko; Jon Williams; Melissa Hilmes; Chris Bowman; Jordan J. Wright; Liping Du; Hakmook Kang; William E. Russell; Alvin C. Powers; Daniel J. Moore
View articletitled, Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset
Supplementary data
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Diabetes Care December 2018, Vol.42, 248-257. doi:https://doi.org/10.2337/dc18-1507

Pathophysiology / Complications

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes
Emily K. Sims; Henry T. Bahnson; Julius Nyalwidhe; Leena Haataja; Asa K. Davis; Cate Speake; Linda A. DiMeglio; Janice Blum; Margaret A. Morris; Raghavendra G. Mirmira; Jerry Nadler; Teresa L. Mastracci; Santica Marcovina; Wei-Jun Qian; Lian Yi; Adam C. Swensen; Michele Yip-Schneider; C. Max Schmidt; Robert V. Considine; Peter Arvan; Carla J. Greenbaum; Carmella Evans-Molina; T1D Exchange Residual C-peptide Study Group
View articletitled, Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes
Supplementary data
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Diabetes Care December 2018, Vol.42, 258-264. doi:https://doi.org/10.2337/dc17-2625
Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes
Joon Young Kim; Fida Bacha; Hala Tfayli; Sara F. Michaliszyn; Shahwar Yousuf; Silva Arslanian
View articletitled, Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes
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Diabetes Care November 2018, Vol.42, 265-272. doi:https://doi.org/10.2337/dc18-1178
Retinopathy and RAAS Activation: Results From the Canadian Study of Longevity in Type 1 Diabetes
Julie A. Lovshin; Yuliya Lytvyn; Leif E. Lovblom; Alexandra Katz; Geneviève Boulet; Petter Bjornstad; Vesta Lai; Leslie Cham; Josephine Tse; Andrej Orszag; Hillary A. Keenan; Narinder Paul; Vera Bril; David T. Wong; Kylen D. McReelis; Michael H. Brent; Bruce A. Perkins; David Z.I. Cherney
View articletitled, Retinopathy and RAAS Activation: Results From the Canadian Study of Longevity in Type 1 Diabetes
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Diabetes Care December 2018, Vol.42, 273-280. doi:https://doi.org/10.2337/dc18-1809
Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
Martha L. Campbell-Thompson; Stephanie L. Filipp; Joseph R. Grajo; Bimota Nambam; Richard Beegle; Erik H. Middlebrooks; Matthew J. Gurka; Mark A. Atkinson; Desmond A. Schatz; Michael J. Haller
View articletitled, Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes
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Diabetes Care December 2018, Vol.42, 281-287. doi:https://doi.org/10.2337/dc18-1512
Incidence and Determinants of Intraocular Lens Implantation in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
Jocelyn J. Drinkwater; Timothy M.E. Davis; Angus W. Turner; David G. Bruce; Wendy A. Davis
View articletitled, Incidence and Determinants of Intraocular Lens Implantation in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
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Diabetes Care December 2018, Vol.42, 288-296. doi:https://doi.org/10.2337/dc18-1556

Cardiovascular and Metabolic Risk

Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study
Petter Bjornstad; Pattara Wiromrat; Richard J. Johnson; Rachel Sippl; David Z.I. Cherney; Randy Wong; Marian J. Rewers; Janet K. Snell-Bergeon
View articletitled, Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study
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Diabetes Care November 2018, Vol.42, 297-302. doi:https://doi.org/10.2337/dc18-1527
Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome
Martin Laclaustra; Belen Moreno-Franco; Jose Manuel Lou-Bonafonte; Rocio Mateo-Gallego; Jose Antonio Casasnovas; Pilar Guallar-Castillon; Ana Cenarro; Fernando Civeira
View articletitled, Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome
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Diabetes Care December 2018, Vol.42, 303-310. doi:https://doi.org/10.2337/dc18-1410
Insulin Clearance After Oral and Intravenous Glucose Following Gastric Bypass and Gastric Banding Weight Loss
Ankit Shah; Marlena M. Holter; Fatima Rimawi; Victoria Mark; Roxanne Dutia; James McGinty; Bruce Levin; Blandine Laferrère
View articletitled, Insulin Clearance After Oral and Intravenous Glucose Following Gastric Bypass and Gastric Banding Weight Loss
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Diabetes Care December 2018, Vol.42, 311-317. doi:https://doi.org/10.2337/dc18-1036
Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL
Lindsay E. Clegg; Hiddo J.L. Heerspink; Robert C. Penland; Weifeng Tang; David W. Boulton; Srinivas Bachina; Robert D. Fox; Peter Fenici; Marcus Thuresson; Robert J. Mentz; Adrian F. Hernandez; Rury R. Holman
View articletitled, Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL
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Diabetes Care December 2018, Vol.42, 318-326. doi:https://doi.org/10.2337/dc18-1871

Novel Communications in Diabetes

Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes
Lena M. Thorn; Sara Shams; Daniel Gordin; Ron Liebkind; Carol Forsblom; Paula Summanen; Stefanie Hägg-Holmberg; Turgut Tatlisumak; Oili Salonen; Jukka Putaala; Juha Martola; Per-Henrik Groop; on behalf of the FinnDiane Study Group
View articletitled, Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes
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Diabetes Care December 2018, Vol.42, 327-330. doi:https://doi.org/10.2337/dc18-1302

Review

Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review
Henry Buchwald; Jane N. Buchwald
View articletitled, Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review
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Diabetes Care January 2019, Vol.42, 331-340. doi:https://doi.org/10.2337/dc17-2654

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes Care January 2019, Vol.42, 341. doi:https://doi.org/10.2337/dc19-ie02

e-Letters

Observations
Incidence Rates of Type 2 Diabetes in People With Impaired Fasting Glucose (ADA vs. WHO Criteria) and Impaired Glucose Tolerance: Results From an Older Population (KORA S4/F4/FF4 Study)
Bernd Kowall; Wolfgang Rathmann; Brenda Bongaerts; Oliver Kuss; Andreas Stang; Michael Roden; Christian Herder; Wolfgang Koenig; Cornelia Huth; Margit Heier; Barbara Thorand; Karl-Heinz Ladwig; Rolf Holle; Christa Meisinger; Annette Peters
View articletitled, Incidence Rates of Type 2 Diabetes in People With Impaired Fasting Glucose (ADA vs. WHO Criteria) and Impaired Glucose Tolerance: Results From an Older Population (KORA S4/F4/FF4 Study)
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Diabetes Care December 2018, Vol.42, e18-e20. doi:https://doi.org/10.2337/dc18-1473
Assessing the Association Between GLP-1 Receptor Agonist Use and Diabetic Retinopathy Through the FDA Adverse Event Reporting System
Tiansheng Wang; Wenchao Lu; Huilin Tang; John B. Buse; Til Stürmer; Emily W. Gower
View articletitled, Assessing the Association Between GLP-1 Receptor Agonist Use and Diabetic Retinopathy Through the FDA Adverse Event Reporting System
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Diabetes Care December 2018, Vol.42, e21-e23. doi:https://doi.org/10.2337/dc18-1893
Comments and Responses
Comment on Desai et al. Health Care Utilization and Burden of Diabetic Ketoacidosis in the U.S. Over the Past Decade: A Nationwide Analysis. Diabetes Care 2018;41:1631–1638
Rodolfo J. Galindo; Cesar Zambrano; Priyathama Vellanki
View articletitled, Comment on Desai et al. Health Care Utilization and Burden of Diabetic Ketoacidosis in the U.S. Over the Past Decade: A Nationwide Analysis. Diabetes Care 2018;41:1631–1638
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Diabetes Care January 2019, Vol.42, e24. doi:https://doi.org/10.2337/dc18-1424
Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431–2437
Michael Holzer; Gunther Marsche
View articletitled, Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431–2437
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Diabetes Care January 2019, Vol.42, e25. doi:https://doi.org/10.2337/dc18-2026
Response to Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431–2437
Anna V. Mathew; Subramaniam Pennathur
View articletitled, Response to Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431–2437
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Diabetes Care January 2019, Vol.42, e26-e27. doi:https://doi.org/10.2337/dci18-0053
Comment on Bergenstal et al. Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring. Diabetes Care 2018;41:2275–2280
Kristen M. Pluchino; Yiduo Wu; Alain D. Silk; Jisun Yi; Courtney H. Lias
View articletitled, Comment on Bergenstal et al. Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring. Diabetes Care 2018;41:2275–2280
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Diabetes Care December 2018, Vol.42, e28. doi:https://doi.org/10.2337/dc18-2366
Response to Comment on Bergenstal et al. Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring. Diabetes Care 2018;41:2275–2280
Richard M. Bergenstal; Roy W. Beck; Kelly L. Close; George Grunberger; David B. Sacks; Aaron Kowalski; Adam S. Brown; Lutz Heinemann; Grazia Aleppo; Donna B. Ryan; Tonya D. Riddlesworth; William T. Cefalu
View articletitled, Response to Comment on Bergenstal et al. Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring. Diabetes Care 2018;41:2275–2280
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Diabetes Care December 2018, Vol.42, e29-e30. doi:https://doi.org/10.2337/dci18-0061
9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes—2025
2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2025
Summary of Revisions: Standards of Care in Diabetes—2025
Hyperglycemic Crises in Adults With Diabetes: A Consensus Report
6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2025
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