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April 2021
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ISSN 0149-5992
EISSN 1935-5548
In this Issue
Editor's Note
A Special Thanks to the Reviewers of Diabetes Care
Topics:
benign hereditary chorea
,
cesar trial
,
chin
,
christianity
,
cluster headache
Diabetes Care March 2021, Vol.44, 855-857. doi:https://doi.org/10.2337/dc21-en04
Perspectives in Care
Resolving the Gestational Diabetes Diagnosis Conundrum: The Need for a Randomized Controlled Trial of Treatment
Topics:
gestational diabetes
,
glucose
,
hapo trial
,
international association of diabetes and pregnancy study groups
,
diabetes, during pregnancy
Diabetes Care March 2021, Vol.44, 858-864. doi:https://doi.org/10.2337/dc20-2941
Clinical Care / Education / Nutrition / Psychosocial Research
Association of Early-Phase In-Hospital Glycemic Fluctuation With Mortality in Adult Patients With Coronavirus Disease 2019
Liangkai Chen; Wenwu Sun; Yanli Liu; Lijuan Zhang; Yanling Lv; Qiang Wang; Ding Long; Yujun Wang; Su Zhao; Shuang Rong; Li Yu; Liegang Liu
Topics:
covid-19
,
fasting blood glucose measurement
,
glucose
,
respiratory distress syndrome, adult
,
glucocorticoids
Diabetes Care January 2021, Vol.44, 865-873. doi:https://doi.org/10.2337/dc20-0780
Cost-effectiveness of Community-Based Depression Interventions for Rural and Urban Adults With Type 2 Diabetes: Projections From Program ACTIVE (Adults Coming Together to Increase Vital Exercise) II
Shihchen Kuo; Wen Ye; Mary de Groot; Chandan Saha; Jay H. Shubrook; W. Guyton Hornsby, Jr.; Yegan Pillay; Kieren J. Mather; William H. Herman
Topics:
cognitive-behavioral therapy
,
depressive disorders
,
diabetes mellitus, type 2
,
sensitivity analysis
,
hemoglobin a, glycosylated
Diabetes Care February 2021, Vol.44, 874-882. doi:https://doi.org/10.2337/dc20-1639
Association of Implementation of a Comprehensive Preconception-to-Pregnancy Management Plan With Pregnancy Outcomes Among Chinese Pregnant Women With Type 1 Diabetes: The CARNATION Study
Xueying Zheng; Daizhi Yang; Sihui Luo; Jinhua Yan; Xiaohui Guo; Huixia Yang; Wei Bao; Leif Groop; Anne Dornhorst; Jianping Weng; CARNATION Study Group
Topics:
adverse pregnancy outcome
,
diabetes mellitus, type 1
,
fetal death
,
pregnancy
,
pregnancy outcome
Diabetes Care March 2021, Vol.44, 883-892. doi:https://doi.org/10.2337/dc20-2692
Examining the Relationship Between Delay Discounting, Delay Aversion, Diabetes Self-care Behaviors, and Diabetes Outcomes in U.S. Adults With Type 2 Diabetes
Topics:
delay discounting
,
diabetes mellitus, type 2
,
diet
,
self care
,
foot care
Diabetes Care February 2021, Vol.44, 893-900. doi:https://doi.org/10.2337/dc20-2620
Epidemiology / Health Services Research
A Validated Prediction Model for End-Stage Kidney Disease in Type 1 Diabetes
Dorte Vistisen; Gregers S. Andersen; Adam Hulman; Stuart J. McGurnaghan; Helen M. Colhoun; Jan E. Henriksen; Reimar W. Thomsen; Frederik Persson; Peter Rossing; Marit E. Jørgensen
Diabetes Care January 2021, Vol.44, 901-907. doi:https://doi.org/10.2337/dc20-2586
Quantifying Variation in Treatment Utilization for Type 2 Diabetes Across Five Major University of California Health Systems
Topics:
diabetes mellitus, type 2
,
health care systems
,
metformin
,
sulfonylurea compounds
,
electronic medical records
Diabetes Care February 2021, Vol.44, 908-914. doi:https://doi.org/10.2337/dc20-0344
Glucose Control, Sulfonylureas, and Insulin Treatment in Elderly People With Type 2 Diabetes and Risk of Severe Hypoglycemia and Death: An Observational Study
Topics:
diabetes mellitus, type 2
,
glycemic control
,
hypoglycemia
,
insulin
,
sulfonylurea compounds
Diabetes Care February 2021, Vol.44, 915-924. doi:https://doi.org/10.2337/dc20-0876
Trends in Total and Out-of-pocket Payments for Noninsulin Glucose-Lowering Drugs Among U.S. Adults With Large-Employer Private Health Insurance From 2005 to 2018
Topics:
hypoglycemic agents
,
glucose
,
metformin
,
thiazolidinedione
,
sulfonylurea compounds
Diabetes Care February 2021, Vol.44, 925-934. doi:https://doi.org/10.2337/dc20-2871
Comparisons of Polyexposure, Polygenic, and Clinical Risk Scores in Risk Prediction of Type 2 Diabetes
Topics:
diabetes mellitus, type 2
Diabetes Care February 2021, Vol.44, 935-943. doi:https://doi.org/10.2337/dc20-2049
Changes in the Diagnosis and Management of Diabetes in Mexico City Between 1998–2004 and 2015–2019
Diego Aguilar-Ramirez; Jesus Alegre-Díaz; Louisa Gnatiuc; Raúl Ramirez-Reyes; Rachel Wade; Michael Hill; Rory Collins; Richard Peto; Jonathan R. Emberson; William G. Herrington; Pablo Kuri-Morales; Roberto Tapia-Conyer
Topics:
glucose
,
hemoglobin a, glycosylated
,
mexico
,
lipid-lowering therapy
,
follow-up
Diabetes Care February 2021, Vol.44, 944-951. doi:https://doi.org/10.2337/dc20-2276
Emerging Therapies: Drugs and Regimens
The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes
Klara R. Klein; Jennifer L.R. Freeman; Imogene Dunn; Chris Dvergsten; M. Sue Kirkman; John B. Buse; Carmen Valcarce; SimpliciT1 research group
Topics:
diabetes mellitus, type 1
,
hemoglobin a, glycosylated
,
hypoglycemia
,
insulin
,
glucokinase
Diabetes Care February 2021, Vol.44, 960-968. doi:https://doi.org/10.2337/dc20-2684
Emerging Technologies: Data Systems and Devices
Improved Glycemic Outcomes With Medtronic MiniMed Advanced Hybrid Closed-Loop Delivery: Results From a Randomized Crossover Trial Comparing Automated Insulin Delivery With Predictive Low Glucose Suspend in People With Type 1 Diabetes
Olivia J. Collyns; Renee A. Meier; Zara L. Betts; Denis S.H. Chan; Chris Frampton; Carla M. Frewen; Niranjala M. Hewapathirana; Shirley D. Jones; Anirban Roy; Benyamin Grosman; Natalie Kurtz; John Shin; Robert A. Vigersky; Benjamin J. Wheeler; Martin I. de Bock
Topics:
diabetes mellitus, type 1
,
glucose
,
hypoglycemia
,
insulin
,
glycemic control
Diabetes Care February 2021, Vol.44, 969-975. doi:https://doi.org/10.2337/dc20-2250
Thresholds of Glycemia and the Outcomes of COVID-19 Complicated With Diabetes: A Retrospective Exploratory Study Using Continuous Glucose Monitoring
Yun Shen; Xiaohong Fan; Lei Zhang; Yaxin Wang; Cheng Li; Jingyi Lu; Bingbing Zha; Yueyue Wu; Xiaohua Chen; Jian Zhou; Weiping Jia
Topics:
continuous glucose monitoring
,
covid-19
,
glucose
,
sensor
Diabetes Care February 2021, Vol.44, 976-982. doi:https://doi.org/10.2337/dc20-1448
Pathophysiology / Complications
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study
Nelly Mauras; Bruce Buckingham; Neil H. White; Eva Tsalikian; Stuart A. Weinzimer; Booil Jo; Allison Cato; Larry A. Fox; Tandy Aye; Ana Maria Arbelaez; Tamara Hershey; Michael Tansey; William Tamborlane; Lara C. Foland-Ross; Hanyang Shen; Kimberly Englert; Paul Mazaika; Matthew Marzelli; Allan L. Reiss; for the Diabetes Research in Children Network (DirecNet)
Topics:
brain
,
child
,
diabetes mellitus, type 1
,
glucose
,
white matter
Diabetes Care February 2021, Vol.44, 983-992. doi:https://doi.org/10.2337/dc20-2125
Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study
Babak Mokhlesi; Ashley H. Tjaden; Karla A. Temple; Sharon L. Edelstein; Susan Sam; Kristen J. Nadeau; Tamara S. Hannon; Shalini Manchanda; Kieren J. Mather; Steven E. Kahn; David A. Ehrmann; Eve Van Cauter; RISE Consortium
Topics:
actigraphy
,
diabetes mellitus, type 2
,
glucose
,
hyperglycemic agents
,
insulin sensitivity
Diabetes Care February 2021, Vol.44, 993-1001. doi:https://doi.org/10.2337/dc20-2127
Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes
Tatsuya Fukuda; Ryotaro Bouchi; Takato Takeuchi; Kikuko Amo-Shiinoki; Atsushi Kudo; Shinji Tanaka; Minoru Tanabe; Takumi Akashi; Kazuhiro Hirayama; Toshitaka Odamaki; Miki Igarashi; Ikuo Kimura; Katsuya Tanabe; Yukio Tanizawa; Tetsuya Yamada; Yoshihiro Ogawa
Topics:
basilar artery stenosis
,
feces
,
glucagon-like peptide 1
,
microbiome
,
oral glucose tolerance test
Diabetes Care February 2021, Vol.44, 1002-1011. doi:https://doi.org/10.2337/dc20-0864
Cardiovascular and Metabolic Risk
Heart Rate and Heart Rate Variability Changes Are Not Related to Future Cardiovascular Disease and Death in People With and Without Dysglycemia: A Downfall of Risk Markers? The Whitehall II Cohort Study
Christian S. Hansen; Marit E. Jørgensen; Marek Malik; Daniel R. Witte; Eric J. Brunner; Adam G. Tabák; Mika Kivimäki; Dorte Vistisen
Topics:
cardiovascular diseases
,
whitehall ii study
,
prediabetes
,
follow-up
Diabetes Care February 2021, Vol.44, 1012-1019. doi:https://doi.org/10.2337/dc20-2490
Changes in Albuminuria Predict Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Post Hoc Analysis of the LEADER Trial
Frederik Persson; Stephen C. Bain; Ofri Mosenzon; Hiddo J.L. Heerspink; Johannes F.E. Mann; Richard Pratley; Itamar Raz; Thomas Idorn; Søren Rasmussen; Bernt Johan von Scholten; Peter Rossing; on behalf of the LEADER Trial Investigators
Topics:
albuminuria
,
diabetes mellitus, type 2
,
kidney
,
urine albumin/creatinine ratio
,
cardiovascular system
Diabetes Care January 2021, Vol.44, 1020-1026. doi:https://doi.org/10.2337/dc20-1622
Liraglutide Increases the Catabolism of Apolipoprotein B100–Containing Lipoproteins in Patients With Type 2 Diabetes and Reduces Proprotein Convertase Subtilisin/Kexin Type 9 Expression
Bruno Vergès; Laurence Duvillard; Jean Paul Pais de Barros; Benjamin Bouillet; Sabine Baillot-Rudoni; Alexia Rouland; Jean Michel Petit; Pascal Degrace; Laurent Demizieux
Topics:
diabetes mellitus, type 2
,
lipoproteins
,
liraglutide
,
mice
,
pcsk9 gene
Diabetes Care February 2021, Vol.44, 1027-1037. doi:https://doi.org/10.2337/dc20-1843
Association of Metabolic Phenotypes With Coronary Artery Disease and Cardiovascular Events in Patients With Stable Chest Pain
Andreas A. Kammerlander; Thomas Mayrhofer; Maros Ferencik; Neha J. Pagidipati; Julia Karady; Geoffrey S. Ginsburg; Michael T. Lu; Daniel O. Bittner; Stefan B. Puchner; Nathan A. Bihlmeyer; Nandini M. Meyersohn; Hamed Emami; Svati H. Shah; Pamela S. Douglas; Udo Hoffmann; on behalf of the PROMISE Investigators
Topics:
chest pain
,
obesity
,
phenotype
,
cardiovascular event
,
coronary arteriosclerosis
Diabetes Care February 2021, Vol.44, 1038-1045. doi:https://doi.org/10.2337/dc20-1760
Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes
Jingyi Qian; Michael P. Walkup; Shyh-Huei Chen; Peter H. Brubaker; Dale S. Bond; Phyllis A. Richey; John M. Jakicic; Kun Hu; Frank A.J.L. Scheer; Roeland J.W. Middelbeek; the Look AHEAD Research Group
Topics:
cardiovascular system
,
diabetes mellitus, type 2
,
coronary heart disease risk
,
depressive disorders
,
look ahead trial
Diabetes Care February 2021, Vol.44, 1046-1054. doi:https://doi.org/10.2337/dc20-2178
Novel Communications in Diabetes
Remote Continuous Glucose Monitoring With a Computerized Insulin Infusion Protocol for Critically Ill Patients in a COVID-19 Medical ICU: Proof of Concept
Georgia M. Davis; Eileen Faulds; Tara Walker; Debbie Vigliotti; Marina Rabinovich; Joi Hester; Limin Peng; Barbara McLean; Patricia Hannon; Norma Poindexter; Petrena Saunders; Citlalli Perez-Guzman; Seema S. Tekwani; Greg S. Martin; Guillermo Umpierrez; Shivani Agarwal; Kathleen Dungan; Francisco J. Pasquel
Topics:
continuous glucose monitoring
,
covid-19
,
critical illness
,
glucose
,
infusion procedures
Diabetes Care February 2021, Vol.44, 1055-1058. doi:https://doi.org/10.2337/dc20-2085
Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin
Topics:
diabetes mellitus, type 2
,
insulin
,
metformin
,
testosterone
,
testosterone measurement, serum
Diabetes Care February 2021, Vol.44, 1059-1061. doi:https://doi.org/10.2337/dc20-1558
Meta-analysis
Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults: A Meta-analysis
Vasudha Ahuja; Pasi Aronen; T.A. Pramodkumar; Helen Looker; Angela Chetrit; Aini H. Bloigu; Auni Juutilainen; Cristina Bianchi; Lucia La Sala; Ranjit Mohan Anjana; Rajendra Pradeepa; Ulagamadesan Venkatesan; Sarvanan Jebarani; Viswanathan Baskar; Teresa Vanessa Fiorentino; Patrick Timpel; Ralph A. DeFronzo; Antonio Ceriello; Stefano Del Prato; Muhammad Abdul-Ghani; Sirkka Keinänen-Kiukaanniemi; Rachel Dankner; Peter H. Bennett; William C. Knowler; Peter Schwarz; Giorgio Sesti; Rie Oka; Viswanathan Mohan; Leif Groop; Jaakko Tuomilehto; Samuli Ripatti; Michael Bergman; Tiinamaija Tuomi
Topics:
deuterium
,
diabetes mellitus, type 2
,
oral glucose tolerance test
,
plasma glucose
,
glucose
Diabetes Care March 2021, Vol.44, 1062-1069. doi:https://doi.org/10.2337/dc20-1688
Errata
Erratum. Health Care Utilization of Homeless Minors With Diabetes in New York State From 2009 to 2014. Diabetes Care 2020;43:2082–2089
Rie Sakai-Bizmark; Laurie A. Mena; Dennys Estevez; Eliza J. Webber; Emily H. Marr; Lauren E.M. Bedel; Jennifer K. Yee
Topics:
health care use
,
homeless persons
Diabetes Care January 2021, Vol.44, 1070. doi:https://doi.org/10.2337/dc21-er04
Erratum. Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study. Diabetes Care 2020;43:843–851
Giulia Ferrannini; Maria Laura Manca; Marco Magnoni; Felicita Andreotti; Daniele Andreini; Roberto Latini; Attilio Maseri; Aldo P. Maggioni; Rachel M. Ostroff; Stephen A. Williams; Ele Ferrannini
Diabetes Care January 2021, Vol.44, 1071. doi:https://doi.org/10.2337/dc21-er04a
Erratum. Clinical Impact of Residual C-Peptide Secretion in Type 1 Diabetes on Glycemia and Microvascular Complications. Diabetes Care 2021;44:390–398
Anita Jeyam; Helen Colhoun; Stuart McGurnaghan; Luke Blackbourn; Timothy J. McDonald; Colin N.A. Palmer; John A. McKnight; Mark W.J. Strachan; Alan W. Patrick; John Chalmers; Robert S. Lindsay; John R. Petrie; Sandeep Thekkepat; Andrew Collier; Sandra MacRury; Paul M. McKeigue; on behalf of SDRNT1BIO Investigators
Topics:
bodily secretions
,
c-peptide
,
diabetes mellitus, type 1
Diabetes Care January 2021, Vol.44, 1072. doi:https://doi.org/10.2337/dc21-er04b
Issues and Events
e-Letters
Observations
How Common Is the Rare Charcot Foot in Patients With Diabetes?
Topics:
charcot's joint of foot
Diabetes Care February 2021, Vol.44, e62-e63. doi:https://doi.org/10.2337/dc20-2590
Association Between DPP-4 Inhibitors and COVID-19–Related Outcomes Among Patients With Type 2 Diabetes
Diabetes Care February 2021, Vol.44, e64-e66. doi:https://doi.org/10.2337/dc20-1824
Survival After Islet Transplantation in Subjects With Type 1 Diabetes: Twenty-Year Follow-Up
Joana R.N. Lemos; David A. Baidal; Camillo Ricordi; Virginia Fuenmayor; Ana Alvarez; Rodolfo Alejandro
Diabetes Care February 2021, Vol.44, e67-e68. doi:https://doi.org/10.2337/dc20-2458
Comments and Responses
Comment on Tynjälä et al. Arterial Stiffness Predicts Mortality in Individuals With Type 1 Diabetes. Diabetes Care 2020;43:2266–2271
José-Miguel González-Clemente; Gemma Llauradó; Albert Cano; Olga Giménez-Palop; Eugenia Berlanga; Joan Vendrell
Topics:
arterial stiffness
,
diabetes mellitus, type 1
Diabetes Care March 2021, Vol.44, e69-e70. doi:https://doi.org/10.2337/dc20-2688
Response to Comment on Tynjälä et al. Arterial Stiffness Predicts Mortality in Individuals With Type 1 Diabetes. Diabetes Care 2020;43:2266–2271
Anniina Tynjälä; Carol Forsblom; Valma Harjutsalo; Per-Henrik Groop; Daniel Gordin; on behalf of the FinnDiane Study Group
Diabetes Care March 2021, Vol.44, e71-e72. doi:https://doi.org/10.2337/dci20-0074
Comment on Samara et al. Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study. Diabetes Care 2020;43:2691–2701
Jorge Rafael Violante-Cumpa; Luis Alberto Pérez-Arredondo; José Gerardo González-González; Leonardo Guadalupe Mancillas-Adame
Topics:
aging
,
cognitive impairment
,
dementia
,
diabetes mellitus, type 2
,
memory
Diabetes Care March 2021, Vol.44, e73. doi:https://doi.org/10.2337/dc20-2881
Response to Comment on Samara et al. Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study. Diabetes Care 2020;43:2691–2701
Katherine Samaras; John D. Crawford; Brian Draper; Julian N. Trollor; Henry Brodaty; Perminder S. Sachdev
Topics:
aging
,
cognitive impairment
,
dementia
,
diabetes mellitus, type 2
,
memory
Diabetes Care March 2021, Vol.44, e74. doi:https://doi.org/10.2337/dci20-0077
Comment on Hásková et al. Real-time CGM Is Superior to Flash Glucose Monitoring for Glucose Control in Type 1 Diabetes: The CORRIDA Randomized Controlled Trial. Diabetes Care 2020;43:2744–2750
Topics:
continuous glucose monitoring
,
diabetes mellitus, type 1
,
glucose measurement by monitoring device
,
glycemic control
Diabetes Care March 2021, Vol.44, e75-e76. doi:https://doi.org/10.2337/dc20-2905
Response to Comment on Hásková et al. Real-time CGM Is Superior to Flash Glucose Monitoring for Glucose Control in Type 1 Diabetes: The CORRIDA Randomized Controlled Trial. Diabetes Care 2020;43:2744–2750
Topics:
continuous glucose monitoring
,
diabetes mellitus, type 1
,
glucose measurement by monitoring device
,
glycemic control
Diabetes Care March 2021, Vol.44, e77-e78. doi:https://doi.org/10.2337/dci20-0078
Comment on Garofolo et al. Insulin Resistance and Risk of Major Vascular Events and All-Cause Mortality in Type 1 Diabetes: A 10-Year Follow-up Study. Diabetes Care 2020;43:e139–e141
José-Miguel González-Clemente; Gemma Llauradó; Lara Albert; Olga Giménez-Palop; Eugenia Berlanga; Joan Vendrell
Diabetes Care March 2021, Vol.44, e79-e80. doi:https://doi.org/10.2337/dc20-2934
Response to Comment on Garofolo et al. Insulin Resistance and Risk of Major Vascular Events and All-Cause Mortality in Type 1 Diabetes: A 10-Year Follow-up Study. Diabetes Care 2020;43:e139–e141
Monia Garofolo; Elisa Gualdani; Cristina Bianchi; Michele Aragona; Fabrizio Campi; Daniela Lucchesi; Giuseppe Daniele; Roberto Miccoli; Paolo Francesconi; Stefano Del Prato; Giuseppe Penno
Topics:
cardiovascular diseases
,
diabetes mellitus, type 1
,
follow-up studies
,
insulin resistance
Diabetes Care March 2021, Vol.44, e81. doi:https://doi.org/10.2337/dci20-0079
