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July 2021
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ISSN 0149-5992
EISSN 1935-5548
In this Issue
Commentary
Weekly Insulin Becoming a Reality
Diabetes Care July 2021, Vol.44, 1459-1461. doi:https://doi.org/10.2337/dci21-0011
Clinical Care / Education / Nutrition / Psychosocial Research
Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial
Noel T. Mueller; Moira K. Differding; Mingyu Zhang; Nisa M. Maruthur; Stephen P. Juraschek; Edgar R. Miller, III; Lawrence J. Appel; Hsin-Chieh Yeh
Diabetes Care May 2021, Vol.44, 1462-1471. doi:https://doi.org/10.2337/dc20-2257
Reductions in Management Distress Following a Randomized Distress Intervention Are Associated With Improved Diabetes Behavioral and Glycemic Outcomes Over Time
Diabetes Care May 2021, Vol.44, 1472-1479. doi:https://doi.org/10.2337/dc20-2724
Barriers to Technology Use and Endocrinology Care for Underserved Communities With Type 1 Diabetes
Ashby F. Walker; Korey K. Hood; Matthew J. Gurka; Stephanie L. Filipp; Claudia Anez-Zabala; Nicolas Cuttriss; Michael J. Haller; Xanadu Roque; Diana Naranjo; Gina Aulisio; Ananta Addala; Jason Konopack; Sarah Westen; Katarina Yabut; Elvira Mercado; Sydney Look; Brian Fitzgerald; Jennifer Maizel; David M. Maahs
Diabetes Care May 2021, Vol.44, 1480-1490. doi:https://doi.org/10.2337/dc20-2753
Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention
Tanja C. Adam; Mathijs Drummen; Ian Macdonald; Elli Jalo; Pia Siig-Vestentoft; J. Alfredo Martinez; Teodora Handjiev-Darlenska; Jennie Brand-Miller; Sally Poppitt; Gareth Stratton; Mikael Fogelholm; Kirsi H. Pietiläinen; Moira Taylor; Santiago Navas-Carretero; Bjorn Winkens; Svetoslav Handjiev; Roslyn Muirhead; Marta Silvestre; Nils Swindell; Maija Huttunen-Lenz; Wolfgang Schlicht; Tony Lam; Jouko Sundvall; Laura Råman; Edith Feskens; Thomas-Meinert Larssen; Angelo Tremblay; Anne Raben; Margriet Westerterp-Plantenga
Diabetes Care July 2021, Vol.44, 1491-1498. doi:https://doi.org/10.2337/dc21-0059
Epidemiology / Health Services Research
Associations of Microvascular Complications With the Risk of Cardiovascular Disease in Type 1 Diabetes
Rose Gubitosi-Klug; Xiaoyu Gao; Rodica Pop-Busui; Ian H. de Boer; Neill White; Lloyd P. Aiello; Ryan Miller; Jerry Palmer; William Tamborlane; Amisha Wallia; Mikhail Kosiborod; John M. Lachin; Ionut Bebu; the DCCT/EDIC Research Group
Diabetes Care May 2021, Vol.44, 1499-1505. doi:https://doi.org/10.2337/dc20-3104
Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes
Noora Nurminen; Damiano Cerrone; Jussi Lehtonen; Anirudra Parajuli; Marja Roslund; Maria Lönnrot; Jorma Ilonen; Jorma Toppari; Riitta Veijola; Mikael Knip; Juho Rajaniemi; Olli H. Laitinen; Aki Sinkkonen; Heikki Hyöty
Diabetes Care May 2021, Vol.44, 1506-1514. doi:https://doi.org/10.2337/dc20-1719
Projecting the Incidence of Type 2 Diabetes–Related End-Stage Kidney Disease Until 2040: A Comparison Between the Effects of Diabetes Prevention and the Effects of Diabetes Treatment
Jedidiah I. Morton; Stephen P. McDonald; Agus Salim; Danny Liew; Jonathan E. Shaw; Dianna J. Magliano
Diabetes Care May 2021, Vol.44, 1515-1523. doi:https://doi.org/10.2337/dc21-0220
American Diabetes Association Framework for Glycemic Control in Older Adults: Implications for Risk of Hospitalization and Mortality
Mary R. Rooney; Olive Tang; Justin B. Echouffo Tcheugui; Pamela L. Lutsey; Morgan E. Grams; B. Gwen Windham; Elizabeth Selvin
Diabetes Care May 2021, Vol.44, 1524-1531. doi:https://doi.org/10.2337/dc20-3045
The Effectiveness of a Proactive, Three-Level Strategy to Identify People With Prediabetes in a Large Workforce With Employer-Sponsored Health Insurance
Diabetes Care May 2021, Vol.44, 1532-1539. doi:https://doi.org/10.2337/dc20-3112
Frequency of Autoantibody-Negative Type 1 Diabetes in Children, Adolescents, and Young Adults During the First Wave of the COVID-19 Pandemic in Germany
Clemens Kamrath; Joachim Rosenbauer; Sascha R. Tittel; Katharina Warncke; Raphael Hirtz; Christian Denzer; Axel Dost; Andreas Neu; Danièle Pacaud; Reinhard W. Holl
Diabetes Care May 2021, Vol.44, 1540-1546. doi:https://doi.org/10.2337/dc20-2791
Risk Factors for Incident Fracture in Older Adults With Type 2 Diabetes: The Framingham Heart Study
Diabetes Care May 2021, Vol.44, 1547-1555. doi:https://doi.org/10.2337/dc20-3150
Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large U.K. Cohort Study
Diabetes Care May 2021, Vol.44, 1556-1563. doi:https://doi.org/10.2337/dc20-2850
Association Between Glucagon-Like Peptide 1 Receptor Agonist and Sodium–Glucose Cotransporter 2 Inhibitor Use and COVID-19 Outcomes
Anna R. Kahkoska; Trine Julie Abrahamsen; G. Caleb Alexander; Tellen D. Bennett; Christopher G. Chute; Melissa A. Haendel; Klara R. Klein; Hemalkumar Mehta; Joshua D. Miller; Richard A. Moffitt; Til Stürmer; Kajsa Kvist; John B. Buse; N3C Consortium
Diabetes Care July 2021, Vol.44, 1564-1572. doi:https://doi.org/10.2337/dc21-0065
Increase in Prevalence of Diabetic Ketoacidosis at Diagnosis Among Youth With Type 1 Diabetes: The SEARCH for Diabetes in Youth Study
Elizabeth T. Jensen; Jeanette M. Stafford; Sharon Saydah; Ralph B. D’Agostino; Lawrence M. Dolan; Jean M. Lawrence; Santica Marcovina; Elizabeth J. Mayer-Davis; Catherine Pihoker; Arleta Rewers; Dana Dabelea
Diabetes Care July 2021, Vol.44, 1573-1578. doi:https://doi.org/10.2337/dc20-0389
Emerging Therapies: Drugs and Regimens
Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial
Harpreet S. Bajaj; Richard M. Bergenstal; Andreas Christoffersen; Melanie J. Davies; Amoolya Gowda; Joakim Isendahl; Ildiko Lingvay; Peter A. Senior; Robert J. Silver; Roberto Trevisan; Julio Rosenstock
Diabetes Care March 2021, Vol.44, 1586-1594. doi:https://doi.org/10.2337/dc20-2877
A Randomized, Open-Label Comparison of Once-Weekly Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
Ildiko Lingvay; John B. Buse; Edward Franek; Melissa V. Hansen; Mette M. Koefoed; Chantal Mathieu; Jeremy Pettus; Karolina Stachlewska; Julio Rosenstock
Diabetes Care April 2021, Vol.44, 1595-1603. doi:https://doi.org/10.2337/dc20-2878
Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial
Johnny Ludvigsson; Zdenek Sumnik; Terezie Pelikanova; Lia Nattero Chavez; Elena Lundberg; Itxaso Rica; Maria A. Martínez-Brocca; Marisol Ruiz de Adana; Jeanette Wahlberg; Anastasia Katsarou; Ragnar Hanas; Cristina Hernandez; Maria Clemente León; Ana Gómez-Gila; Marcus Lind; Marta Ferrer Lozano; Theo Sas; Ulf Samuelsson; Stepanka Pruhova; Fabricia Dietrich; Sara Puente Marin; Anders Nordlund; Ulf Hannelius; Rosaura Casas
Diabetes Care May 2021, Vol.44, 1604-1612. doi:https://doi.org/10.2337/dc21-0318
Effect of Recombinant Human Parathyroid Hormone (1-84) on Resolution of Active Charcot Neuro-osteoarthropathy in Diabetes: A Randomized, Double-Blind, Placebo-Controlled Study
Nina L. Petrova; Nicholas K. Donaldson; Maureen Bates; Wegin Tang; Timothy Jemmott; Victoria Morris; Tracy Dew; Lisa Meacock; David A. Elias; Cajetan F. Moniz; Michael E. Edmonds
Diabetes Care July 2021, Vol.44, 1613-1621. doi:https://doi.org/10.2337/dc21-0008
The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure–Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial
Tu N. Nguyen; Katie Harris; Mark Woodward; John Chalmers; Mark Cooper; Pavel Hamet; Stephen Harrap; Simon Heller; Stephen MacMahon; Giuseppe Mancia; Michel Marre; Neil Poulter; Anthony Rogers; Bryan Williams; Sophia Zoungas; Clara K. Chow; Richard I. Lindley
Diabetes Care May 2021, Vol.44, 1622-1629. doi:https://doi.org/10.2337/dc20-2664
Emerging Technologies: Data Systems and Devices
Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes
Sue A. Brown; Gregory P. Forlenza; Bruce W. Bode; Jordan E. Pinsker; Carol J. Levy; Amy B. Criego; David W. Hansen; Irl B. Hirsch; Anders L. Carlson; Richard M. Bergenstal; Jennifer L. Sherr; Sanjeev N. Mehta; Lori M. Laffel; Viral N. Shah; Anuj Bhargava; Ruth S. Weinstock; Sarah A. MacLeish; Daniel J. DeSalvo; Thomas C. Jones; Grazia Aleppo; Bruce A. Buckingham; Trang T. Ly; Omnipod 5 Research Group
Diabetes Care July 2021, Vol.44, 1630-1640. doi:https://doi.org/10.2337/dc21-0172
Accuracy of Dexcom G6 Continuous Glucose Monitoring in Non–Critically Ill Hospitalized Patients With Diabetes
Georgia M. Davis; Elias K. Spanakis; Alexandra L. Migdal; Lakshmi G. Singh; Bonnie Albury; Maria Agustina Urrutia; K. Walkiria Zamudio-Coronado; William H. Scott; Rebecca Doerfler; Sergio Lizama; Medha Satyarengga; Kashif Munir; Rodolfo J. Galindo; Priyathama Vellanki; Saumeth Cardona; Francisco J. Pasquel; Limin Peng; Guillermo E. Umpierrez
Diabetes Care July 2021, Vol.44, 1641-1646. doi:https://doi.org/10.2337/dc20-2856
Pathophysiology / Complications
Hemodialysis-Related Glycemic Disarray Proven by Continuous Glucose Monitoring; Glycemic Markers and Hypoglycemia
Akinori Hayashi; Naoya Shimizu; Agena Suzuki; Kenta Matoba; Akari Momozono; Tsuguto Masaki; Akifumi Ogawa; Ibuki Moriguchi; Koji Takano; Naoyuki Kobayashi; Masayoshi Shichiri
Diabetes Care May 2021, Vol.44, 1647-1656. doi:https://doi.org/10.2337/dc21-0269
Cardiovascular and Metabolic Risk
High Burden of Subclinical and Cardiovascular Disease Risk in Adults With Metabolically Healthy Obesity: The Atherosclerosis Risk in Communities (ARIC) Study
Yvonne Commodore-Mensah; Mariana Lazo; Olive Tang; Justin B. Echouffo-Tcheugui; Chiadi E. Ndumele; Vijay Nambi; Dan Wang; Christie Ballantyne; Elizabeth Selvin
Diabetes Care May 2021, Vol.44, 1657-1663. doi:https://doi.org/10.2337/dc20-2227
Long-term Predictions of Incident Coronary Artery Calcium to 85 Years of Age for Asymptomatic Individuals With and Without Type 2 Diabetes
Bart S. Ferket; M.G. Myriam Hunink; Umesh Masharani; Wendy Max; Joseph Yeboah; Kirsten E. Fleischmann
Diabetes Care July 2021, Vol.44, 1664-1671. doi:https://doi.org/10.2337/dc20-1960
Dose-Dependent Associations of Dietary Glycemic Index, Glycemic Load, and Fiber With 3-Year Weight Loss Maintenance and Glycemic Status in a High-Risk Population: A Secondary Analysis of the Diabetes Prevention Study PREVIEW
Ruixin Zhu; Thomas M. Larsen; Mikael Fogelholm; Sally D. Poppitt; Pia S. Vestentoft; Marta P. Silvestre; Elli Jalo; Santiago Navas-Carretero; Maija Huttunen-Lenz; Moira A. Taylor; Gareth Stratton; Nils Swindell; Mathijs Drummen; Tanja C. Adam; Christian Ritz; Jouko Sundvall; Liisa M. Valsta; Roslyn Muirhead; Shannon Brodie; Teodora Handjieva-Darlenska; Svetoslav Handjiev; J. Alfredo Martinez; Ian A. Macdonald; Margriet S. Westerterp-Plantenga; Jennie Brand-Miller; Anne Raben
Diabetes Care May 2021, Vol.44, 1672-1681. doi:https://doi.org/10.2337/dc20-3092
Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort
Zhila Semnani-Azad; Philip W. Connelly; Richard P. Bazinet; Ravi Retnakaran; David J.A. Jenkins; Stewart B. Harris; Bernard Zinman; Anthony J. Hanley
Diabetes Care May 2021, Vol.44, 1682-1691. doi:https://doi.org/10.2337/dc20-1918
Differences in Body Composition Convey a Similar Risk of Type 2 Diabetes Among Different Ethnic Groups With Disparate Cardiometabolic Risk—The HELIUS Study
Marleen Zethof; Charlotte M. Mosterd; Didier Collard; Henrike Galenkamp; Charles Agyemang; Max Nieuwdorp; Daniël H. van Raalte; Bert-Jan H. van den Born
Diabetes Care May 2021, Vol.44, 1692-1698. doi:https://doi.org/10.2337/dc21-0230
Type 2 Diabetes, Metabolic Traits, and Risk of Heart Failure: A Mendelian Randomization Study
Ify R. Mordi; R. Thomas Lumbers; Colin N.A. Palmer; Ewan R. Pearson; Naveed Sattar; Michael V. Holmes; Chim C. Lang; on behalf of the HERMES Consortium
Diabetes Care July 2021, Vol.44, 1699-1705. doi:https://doi.org/10.2337/dc20-2518
The Relationship Between Body Fat Distribution and Nonalcoholic Fatty Liver in Adults With Type 1 Diabetes
Erika B. Parente; Emma H. Dahlström; Valma Harjutsalo; Jussi Inkeri; Stefan Mutter; Carol Forsblom; Niina Sandholm; Daniel Gordin; Per-Henrik Groop; on behalf of the FinnDiane Study Group
Diabetes Care May 2021, Vol.44, 1706-1713. doi:https://doi.org/10.2337/dc20-3175
Diabetic Polyneuropathy Early in Type 2 Diabetes Is Associated With Higher Incidence Rate of Cardiovascular Disease: Results From Two Danish Cohort Studies
Lasse Bjerg; Sia K. Nicolaisen; Diana H. Christensen; Jens S. Nielsen; Signe T. Andersen; Marit E. Jørgensen; Troels S. Jensen; Annelli Sandbæk; Henning Andersen; Henning Beck-Nielsen; Henrik T. Sørensen; Daniel R. Witte; Reimar W. Thomsen; Morten Charles
Diabetes Care May 2021, Vol.44, 1714-1721. doi:https://doi.org/10.2337/dc21-0010
Novel Communications in Diabetes
Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?
Jean-Baptiste Julla; Pauline Jacquemier; Guy Fagherazzi; Tiphaine Vidal-Trecan; Vanessa Juddoo; Asma Jaziri; Hanane Mersel; Nicolas Venteclef; Ronan Roussel; Pascale Massin; Aude Couturier; Jean-François Gautier; Jean-Pierre Riveline
Diabetes Care July 2021, Vol.44, 1722-1725. doi:https://doi.org/10.2337/dc20-1847
Issues and Events
e-Letters
Observations
Factors Associated With Healing of Diabetes-Related Foot Ulcers: Observations From a Large Prospective Real-World Cohort
Yuqi Zhang; Susanna Cramb; Steven M. McPhail; Rosana Pacella; Jaap J. van Netten; Qinglu Cheng; Patrick H. Derhy; Ewan M. Kinnear; Peter A. Lazzarini; on behalf of the Diabetic Foot Working Group, Queensland Statewide Diabetes Clinical Network, Australia
Diabetes Care July 2021, Vol.44, e143-e145. doi:https://doi.org/10.2337/dc20-3120
Increase in Diabetes Mortality Associated With COVID-19 Pandemic in the U.S.
Diabetes Care July 2021, Vol.44, e146-e147. doi:https://doi.org/10.2337/dc21-0213
User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics
Natalie S. Chen; Charlotte K. Boughton; Sara Hartnell; Julia Fuchs; Janet M. Allen; Malgorzata E. Willinska; Ajay Thankamony; Carine de Beaufort; Fiona M. Campbell; Elke Fröhlich-Reiterer; Sabine E. Hofer; Thomas M. Kapellen; Birgit Rami-Merhar; Atrayee Ghatak; Tabitha L. Randell; Rachel E. J. Besser; Daniela Elleri; Nicola Trevelyan; Louise Denvir; Nikki Davis; Eleanor Gurnell; Robert Lindsay; Damian Morris; Eleanor M. Scott; Lia Bally; Hood Thabit; Lalantha Leelarathna; Mark L. Evans; Helen R. Murphy; Julia K. Mader; Roman Hovorka; on behalf of AiDAPT, AP@home04, CLOuD, DAN05, DAN06, and KidsAP consortia
Diabetes Care July 2021, Vol.44, e148-e150. doi:https://doi.org/10.2337/dc20-2762
Artificial Intelligence–Based Classification of Diabetic Peripheral Neuropathy From Corneal Confocal Microscopy Images
Tooba Salahouddin; Ioannis N. Petropoulos; Maryam Ferdousi; Georgios Ponirakis; Omar Asghar; Uazman Alam; Saadat Kamran; Ziyad R. Mahfoud; Nathan Efron; Rayaz A. Malik; Uvais A. Qidwai
Diabetes Care July 2021, Vol.44, e151-e153. doi:https://doi.org/10.2337/dc20-2012
