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February 2022
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ISSN 0149-5992
EISSN 1935-5548
In this Issue
Perspectives in Care
ADA/EASD Precision Medicine in Diabetes Initiative: An International Perspective and Future Vision for Precision Medicine in Diabetes
John J. Nolan; Anna R. Kahkoska; Zhila Semnani-Azad; Marie-France Hivert; Linong Ji; Viswanathan Mohan; Robert H. Eckel; Louis H. Philipson; Stephen S. Rich; Chandra Gruber; Paul W. Franks
Topics:
precision medicine
,
vision
,
genetics
,
partnerships
,
phenotype
Diabetes Care January 2022, Vol.45, 261-266. doi:https://doi.org/10.2337/dc21-2216
Controversies Around the Measurement of Blood Ketones to Diagnose and Manage Diabetic Ketoacidosis
Topics:
diabetic ketoacidosis
,
ketones
Diabetes Care January 2022, Vol.45, 267-272. doi:https://doi.org/10.2337/dc21-2279
Commentary
The Brains Behind SGLT2 Inhibition
Topics:
brain
,
empagliflozin
,
insulin
,
sodium-glucose transporter 2 inhibitors
,
hypothalamus
Diabetes Care January 2022, Vol.45, 273-275. doi:https://doi.org/10.2337/dci21-0050
Clinical Care / Education / Nutrition / Psychosocial Research
Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES
Topics:
cobalamin
,
metformin
,
diabetes mellitus, type 2
,
diet
Diabetes Care December 2021, Vol.45, 276-284. doi:https://doi.org/10.2337/dc21-1674
Trends in Glycemic Control Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study
Faisal S. Malik; Katherine A. Sauder; Scott Isom; Beth A. Reboussin; Dana Dabelea; Jean M. Lawrence; Alissa Roberts; Elizabeth J. Mayer-Davis; Santica Marcovina; Lawrence Dolan; Daria Igudesman; Catherine Pihoker; for the SEARCH for Diabetes in Youth Study
Topics:
adolescent
,
diabetes mellitus, type 1
,
diabetes mellitus, type 2
,
glycemic control
,
hemoglobin a, glycosylated
Diabetes Care January 2022, Vol.45, 285-294. doi:https://doi.org/10.2337/dc21-0507
Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation
Sarah E. Swauger; Lindsey N. Hornung; Deborah A. Elder; Appakalai N. Balamurugan; David S. Vitale; Tom K. Lin; Jaimie D. Nathan; Maisam Abu-El-Haija
Topics:
insulin
,
c-peptide
,
transplantation, autologous
,
postoperative care
,
pancreatectomy
Diabetes Care January 2022, Vol.45, 295-302. doi:https://doi.org/10.2337/dc21-1222
Epidemiology / Health Services Research
Factors Associated With Nonattendance in a Nationwide Screening Program for Diabetic Retinopathy: A Register-Based Cohort Study
Gabriela B. Petersen; Stine Byberg; Dorte Vistisen; Mia V. Fangel; Henrik Vorum; Lene E. Joensen; Jette K. Kristensen
Topics:
diabetes mellitus, type 2
,
diabetic retinopathy
,
diabetic retinopathy screening
,
screening
,
denmark
Diabetes Care November 2021, Vol.45, 303-310. doi:https://doi.org/10.2337/dc21-1380
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes
Brandon M. Nathan; Maria J. Redondo; Heba Ismail; Laura Jacobsen; Emily K. Sims; Jerry Palmer; Jay Skyler; Laura Bocchino; Susan Geyer; Jay M. Sosenko
Topics:
c-peptide
,
deuterium
,
diabetes mellitus, type 1
,
glucose
,
autoantibodies
Diabetes Care December 2021, Vol.45, 311-318. doi:https://doi.org/10.2337/dc21-0944
Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank
Han Han; Yaying Cao; Chengwu Feng; Yan Zheng; Klodian Dhana; Shu Zhu; Cong Shang; Changzheng Yuan; Geng Zong
Topics:
biobanks
,
diabetes mellitus, type 2
,
healthy lifestyle
,
life style
,
digestive system disorders
Diabetes Care December 2021, Vol.45, 319-329. doi:https://doi.org/10.2337/dc21-1512
Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort
Katharina Herzog; Tomas Andersson; Valdemar Grill; Niklas Hammar; Håkan Malmström; Mats Talbäck; Göran Walldius; Sofia Carlsson
Topics:
biological markers
,
diabetes mellitus, type 1
,
glucose
,
triglycerides
,
inflammation
Diabetes Care December 2021, Vol.45, 330-338. doi:https://doi.org/10.2337/dc21-1238
Associations of Daily Steps and Step Intensity With Incident Diabetes in a Prospective Cohort Study of Older Women: The OPACH Study
Alexis C. Garduno; Andrea Z. LaCroix; Michael J. LaMonte; David W. Dunstan; Kelly R. Evenson; Guangxing Wang; Chongzhi Di; Benjamin T. Schumacher; John Bellettiere
Topics:
older adult
,
accelerometers
,
physical function
,
diabetes mellitus, type 2
,
prospective studies
Diabetes Care January 2022, Vol.45, 339-347. doi:https://doi.org/10.2337/dc21-1202
Lifestyle Changes and Long-term Weight Gain in Women With and Without a History of Gestational Diabetes Mellitus: A Prospective Study of 54,062 Women in the Nurses’ Health Study II
Jiaxi Yang; Cuilin Zhang; Jorge E. Chavarro; Janet W. Rich-Edwards; Molin Wang; Wafaie W. Fawzi; JoAnn E. Manson; I-Min Lee; Frank B. Hu; Deirdre K. Tobias
Topics:
body weight changes
,
diet
,
weight gain
,
follow-up
,
life style
Diabetes Care December 2021, Vol.45, 348-356. doi:https://doi.org/10.2337/dc21-1692
Risk of Foot Ulcer and Lower-Extremity Amputation Among Participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
Edward J. Boyko; Leila R. Zelnick; Barbara H. Braffett; Rodica Pop-Busui; Catherine C. Cowie; Gayle M. Lorenzi; Rose Gubitosi-Klug; Bernard Zinman; Ian H. de Boer; for the DCCT/EDIC Research Group
Topics:
dcct trial
,
diabetic foot ulcer
,
edic trial
,
hemoglobin a, glycosylated
,
follow-up
Diabetes Care January 2022, Vol.45, 357-364. doi:https://doi.org/10.2337/dc21-1816
CGM Metrics Predict Imminent Progression to Type 1 Diabetes: Autoimmunity Screening for Kids (ASK) Study
Andrea K. Steck; Fran Dong; Cristy Geno Rasmussen; Kimberly Bautista; Flor Sepulveda; Judith Baxter; Liping Yu; Brigitte I. Frohnert; Marian J. Rewers; for the ASK Study Group
Topics:
autoantibodies
,
child
,
continuous glucose monitoring
,
diabetes mellitus, type 1
,
screening
Diabetes Care December 2021, Vol.45, 365-371. doi:https://doi.org/10.2337/dc21-0602
Utilization Rates of SGLT2 Inhibitors and GLP-1 Receptor Agonists and Their Facility-Level Variation Among Patients With Atherosclerotic Cardiovascular Disease and Type 2 Diabetes: Insights From the Department of Veterans Affairs
Dhruv Mahtta; David J. Ramsey; Michelle T. Lee; Liang Chen; Mahmoud Al Rifai; Julia M. Akeroyd; Elizabeth M. Vaughan; Michael E. Matheny; Karla Rodrigues do Espirito Santo; Sankar D. Navaneethan; Carl J. Lavie; Yochai Birnbaum; Christie M. Ballantyne; Laura A. Petersen; Salim S. Virani
Topics:
atherosclerosis
,
diabetes mellitus, type 2
,
glucagon-like peptide 1
,
hypoglycemic agents
,
glucagon-like peptide-1 agonists
Diabetes Care January 2022, Vol.45, 372-380. doi:https://doi.org/10.2337/dc21-1815
Emerging Technologies: Data Systems and Devices
Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial
Sybil A. McAuley; Steven Trawley; Sara Vogrin; Glenn M. Ward; Spiros Fourlanos; Charlotte A. Grills; Melissa H. Lee; Andisheh Mohammad Alipoor; David N. O’Neal; Niamh A. O’Regan; Vijaya Sundararajan; Peter G. Colman; Richard J. MacIsaac
Topics:
continuous glucose monitoring
,
diabetes mellitus, type 1
,
glucose
,
hypoglycemia
,
insulin
Diabetes Care November 2021, Vol.45, 381-390. doi:https://doi.org/10.2337/dc21-1667
Universal Subsidized Continuous Glucose Monitoring Funding for Young People With Type 1 Diabetes: Uptake and Outcomes Over 2 Years, a Population-Based Study
Stephanie R. Johnson; Deborah J. Holmes-Walker; Melissa Chee; Arul Earnest; Timothy W. Jones; on behalf of the CGM Advisory Committee and Working Party and the ADDN Study Group
Topics:
continuous glucose monitoring
,
hemoglobin a, glycosylated
,
diabetic ketoacidosis
,
hypoglycemia
,
glycemic control
Diabetes Care December 2021, Vol.45, 391-397. doi:https://doi.org/10.2337/dc21-1666
Pathophysiology / Complications
Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial
Stephanie Kullmann; Julia Hummel; Robert Wagner; Corinna Dannecker; Andreas Vosseler; Louise Fritsche; Ralf Veit; Konstantinos Kantartzis; Jürgen Machann; Andreas L. Birkenfeld; Norbert Stefan; Hans-Ulrich Häring; Andreas Peter; Hubert Preissl; Andreas Fritsche; Martin Heni
Topics:
brain
,
empagliflozin
,
hypothalamus
,
insulin
,
insulin sensitivity
Diabetes Care October 2021, Vol.45, 398-406. doi:https://doi.org/10.2337/dc21-1136
Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes
Kamel Mohammedi; Yawa Abouleka; Charlyne Carpentier; Louis Potier; Severine Dubois; Ninon Foussard; Vincent Rigalleau; Jean-François Gautier; Pierre Gourdy; Guillaume Charpentier; Ronan Roussel; André Scheen; Bernard Bauduceau; Samy Hadjadj; François Alhenc-Gelas; Michel Marre; Gilberto Velho
Topics:
angiotensin-converting enzyme inhibitors
,
diabetes mellitus, type 1
,
follow-up
,
genotype
,
amputation
Diabetes Care December 2021, Vol.45, 407-415. doi:https://doi.org/10.2337/dc21-0973
Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity
Jennifer L. Rosenbaum; Susan J. Melhorn; Stefan Schoen; Mary F. Webb; Mary Rosalynn B. De Leon; Madelaine Humphreys; Kristina M. Utzschneider; Ellen A. Schur
Topics:
gliosis
,
glucose
,
obesity
,
transverse spin relaxation time
,
glucose homeostasis
Diabetes Care November 2021, Vol.45, 416-424. doi:https://doi.org/10.2337/dc21-1535
Impaired Insulin Clearance as the Initial Regulator of Obesity-Associated Hyperinsulinemia: Novel Insight Into the Underlying Mechanism Based on Serum Bile Acid Profiles
Zhenzhen Fu; Qinyi Wu; Wen Guo; Jingyu Gu; Xuqin Zheng; Yingyun Gong; Chenyan Lu; Jingya Ye; Xuan Ye; Wanzi Jiang; Moran Hu; Baowen Yu; Qi Fu; Xiang Liu; Jianling Bai; John Zhong Li; Tao Yang; Hongwen Zhou
Topics:
basilar artery stenosis
,
drug clearance
,
insulin
,
obesity
,
hyperinsulinism
Diabetes Care December 2021, Vol.45, 425-435. doi:https://doi.org/10.2337/dc21-1023
Structural Lesions on Kidney Biopsy in Youth-Onset and Adult-Onset Type 2 Diabetes
Helen C. Looker; Laura Pyle; Tim Vigers; Cameron Severn; Pierre J. Saulnier; Behzad Najafian; Michael Mauer; Robert G. Nelson; Petter Bjornstad
Topics:
adolescent
,
diabetes mellitus, type 2
,
renal biopsy
Diabetes Care January 2022, Vol.45, 436-443. doi:https://doi.org/10.2337/dc21-1688
Cardiovascular and Metabolic Risk
Association of Bariatric Surgery With Cancer Incidence in Patients With Obesity and Diabetes: Long-term Results From the Swedish Obese Subjects Study
Kajsa Sjöholm; Lena M.S. Carlsson; Per-Arne Svensson; Johanna C. Andersson-Assarsson; Felipe Kristensson; Peter Jacobson; Markku Peltonen; Magdalena Taube
Topics:
cancer
,
follow-up
,
obesity
,
bariatric surgery
,
surgical procedures, operative
Diabetes Care November 2021, Vol.45, 444-450. doi:https://doi.org/10.2337/dc21-1335
Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses’ Health Study and the Health Professionals Follow-up Study
Topics:
cancer
,
cardiovascular diseases
,
diet
,
hpfs trial
,
nurses' health study
Diabetes Care November 2021, Vol.45, 451-459. doi:https://doi.org/10.2337/dc21-1530
Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study
Susan Martin; Elena P. Sorokin; E. Louise Thomas; Naveed Sattar; Madeleine Cule; Jimmy D. Bell; Hanieh Yaghootkar
Topics:
diabetes mellitus, type 2
,
liver
,
pancreas
,
diabetes mellitus, type 1
,
biobanks
Diabetes Care January 2022, Vol.45, 460-468. doi:https://doi.org/10.2337/dc21-1262
Role of the Gut in the Temporal Changes of β-Cell Function After Gastric Bypass in Individuals With and Without Diabetes Remission
Malini Prasad; Victoria Mark; Chanel Ligon; Roxanne Dutia; Nandini Nair; Ankit Shah; Blandine Laferrère
Topics:
disease remission
,
glucose
,
surgery specialty
,
surgical procedures, operative
,
insulin
Diabetes Care December 2021, Vol.45, 469-476. doi:https://doi.org/10.2337/dc21-1270
Novel Communications in Diabetes
Circulating Metabolites and the Development of Type 2 Diabetes in Chinese Adults
Fiona Bragg; Christiana Kartsonaki; Yu Guo; Michael Holmes; Huaidong Du; Canqing Yu; Pei Pei; Ling Yang; Donghui Jin; Yiping Chen; Dan Schmidt; Daniel Avery; Jun Lv; Junshi Chen; Robert Clarke; Michael Hill; Liming Li; Iona Millwood; Zhengming Chen
Topics:
diabetes mellitus, type 2
,
metabolites
Diabetes Care November 2021, Vol.45, 477-480. doi:https://doi.org/10.2337/dc21-1415
Differentiating Diabetic Ketoacidosis and Hyperglycemic Ketosis Due to Cannabis Hyperemesis Syndrome in Adults With Type 1 Diabetes
Halis Kaan Akturk; Janet Snell-Bergeon; Gregory L. Kinney; Anagha Champakanath; Andrew Monte; Viral N. Shah
Topics:
cannabis
,
diabetes mellitus, type 1
,
diabetic ketoacidosis
,
hyperemesis gravidarum
,
hyperglycemic agents
Diabetes Care December 2021, Vol.45, 481-483. doi:https://doi.org/10.2337/dc21-1730
National Standards
2022 National Standards for Diabetes Self-Management Education and Support
Jody Davis, CDCES; Amy Hess Fischl, BC-ADM, CDCES; Joni Beck, BC-ADM, CDCES; Lillian Browning, CDCES; Amy Carter, CDCES; Jo Ellen Condon, CDCES; Michelle Dennison, BC-ADM, CDCES; Terri Francis, CDCES; Peter J. Hughes; Stephen Jaime; Ka Hei Karen Lau, CDCES; Teresa McArthur, CDCES; Karen McAvoy, CDCES; Michelle Magee; Olivia Newby, CDCES; Stephen W. Ponder, CDCES; Uzma Quraishi; Kelly Rawlings; Julia Socke, CDCES; Michelle Stancil, CDCES; Sacha Uelmen, CDCES; Suzanne Villalobos, BC-ADM
Topics:
evidence-based practice
,
national standards
,
self-management
Diabetes Care January 2022, Vol.45, 484-494. doi:https://doi.org/10.2337/dc21-2396
Issues and Events
Issues and Events
Topics:
covid-19
,
diabetes mellitus, type 2
,
kidney failure, chronic
,
podcasts
Diabetes Care January 2022, Vol.45, 495. doi:https://doi.org/10.2337/dc22-ie02
e-Letters
Observations
Trends in Prevalence and Awareness of Prediabetes Among Adults in the U.S., 2005–2020
Peng-Fei Xia; Yu-Xuan Tian; Ting-Ting Geng; Yue Li; Zhou-Zheng Tu; Yan-Bo Zhang; Kunquan Guo; Kun Yang; Gang Liu; An Pan
Diabetes Care December 2021, Vol.45, e21-e23. doi:https://doi.org/10.2337/dc21-2100
Impact of COVID-19 Vaccination on Glycemia in Individuals With Type 1 and Type 2 Diabetes: Substudy of the COVAC-DM Study
Felix Aberer; Othmar Moser; Faisal Aziz; Caren Sourij; Haris Ziko; Jacqueline Lenz; Farah Abbas; Anna M. Obermayer; Harald Kojzar; Peter N. Pferschy; Alexander Müller; Christina Unteregger; Marlies Leitner; Tamara Banfic; Max L. Eckstein; Nadine Wachsmuth; Susanne Kaser; Julia K. Mader; Norbert J. Tripolt; Harald Sourij; for the COVAC-DM Study Group
Topics:
covid-19 vaccines
,
diabetes mellitus, type 2
,
vaccination
,
adverse effects
,
continuous glucose monitoring
Diabetes Care November 2021, Vol.45, e24-e26. doi:https://doi.org/10.2337/dc21-1563
Effect of Dapagliflozin on Hematocrit in Patients With Type 2 Diabetes at High Cardiovascular Risk: Observations From DECLARE-TIMI 58
Ahmed A. Kolkailah; Stephen D. Wiviott; Itamar Raz; Sabina A. Murphy; Ofri Mosenzon; Deepak L. Bhatt; Lawrence A. Leiter; John P.H. Wilding; Ingrid Gause-Nilsson; Marc S. Sabatine; Darren K. McGuire
Topics:
dapagliflozin
,
diabetes mellitus, type 2
,
heart disease risk factors
,
hematocrit
,
timi grading system
Diabetes Care January 2022, Vol.45, e27-e29. doi:https://doi.org/10.2337/dc21-1668
GLP-1 Receptor Agonists for Cardiovascular Protection: A Matter of Time
Diabetes Care January 2022, Vol.45, e30-e31. doi:https://doi.org/10.2337/dc21-1839
Socioeconomic Factors Play a More Important Role than Clinical Needs in the Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in People With Type 2 Diabetes
Topics:
diabetes mellitus, type 2
,
glucagon-like peptide-1 agonists
,
sodium-glucose transporter 2 inhibitors
,
kidney failure, chronic
,
atherosclerosis
Diabetes Care January 2022, Vol.45, e32-e33. doi:https://doi.org/10.2337/dc21-1800
Factors Associated With Discontinuation of Subspecialty Diabetes Care During the COVID-19 Pandemic: A Multisite Retrospective Cohort Study
Topics:
coronavirus pandemic
,
hemoglobin a, glycosylated
,
pandemics
,
telehealth
Diabetes Care January 2022, Vol.45, e34-e36. doi:https://doi.org/10.2337/dc21-1360
Comments and Responses
Comment on Lee et al. Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study. Diabetes Care 2021;44:2419–2426
Topics:
diabetes mellitus, type 2
,
propensity score method
,
retinal vein occlusion
,
sodium-glucose transporter 2 inhibitors
Diabetes Care January 2022, Vol.45, e37. doi:https://doi.org/10.2337/dc21-1878
Response to Comment on Lee et al. Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study. Diabetes Care 2021; 44:2419–2426
Topics:
diabetes mellitus, type 2
,
propensity score method
,
retinal vein occlusion
,
sodium-glucose transporter 2 inhibitors
Diabetes Care January 2022, Vol.45, e38. doi:https://doi.org/10.2337/dci21-0049
Comment on Ipp and Kumar. A Clinical Conundrum: Intensifying Glucose Control in the Presence of Advanced Diabetic Retinopathy. Diabetes Care 2021;44:2192–2193
Vincent Rigalleau; Alice Larroumet; Kamel Mohammedi; Laurence Baillet-Blanco; Marie Monlun; Marie-Noelle Delyfer; Jean-François Korobelnik; Ninon Foussard
Diabetes Care January 2022, Vol.45, e39. doi:https://doi.org/10.2337/dc21-2071
Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826–1834
Topics:
c-peptide
,
diabetes mellitus, type 1
,
fetus
,
hyperinsulinism
,
pancreas
Diabetes Care January 2022, Vol.45, e41-e42. doi:https://doi.org/10.2337/dc21-2072
Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826–1834
Claire L. Meek; Richard A. Oram; Timothy J. McDonald; Denice S. Feig; Andrew T. Hattersley; Helen R. Murphy; on behalf of the CONCEPTT Collaborative Group
Topics:
c-peptide
,
diabetes mellitus, type 1
,
fetus
,
hyperinsulinism
,
pancreas
Diabetes Care January 2022, Vol.45, e43-e44. doi:https://doi.org/10.2337/dci21-0054
Comment on Khunti et al. COVID-19, Hyperglycemia, and New-Onset Diabetes. Diabetes Care 2021;44:2645–2655
Carmine Gazzaruso; Adriana Coppola; Pietro Gallotti; Ileana Terruzzi; Tiziana Montalcini; Livio Luzi
Topics:
covid-19
,
hyperglycemia
Diabetes Care January 2022, Vol.45, e45. doi:https://doi.org/10.2337/dc21-2241
