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March 2022
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Cover: Floral watercolor portrait of a young spiritual ethereal woman.
Credit: Kateryna Kovarzh. For more information, please visit istockphoto.com.
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ISSN 0149-5992
EISSN 1935-5548
In this Issue
Profiles in Progress
Clinical Care / Education / Nutrition / Psychosocial Research
Prediction of Personal Glycemic Responses to Food for Individuals With Type 1 Diabetes Through Integration of Clinical and Microbial Data
Smadar Shilo; Anastasia Godneva; Marianna Rachmiel; Tal Korem; Dmitry Kolobkov; Tal Karady; Noam Bar; Bat Chen Wolf; Yitav Glantz-Gashai; Michal Cohen; Nehama Zuckerman Levin; Naim Shehadeh; Noah Gruber; Neriya Levran; Shlomit Koren; Adina Weinberger; Orit Pinhas-Hamiel; Eran Segal
Diabetes Care October 2021, Vol.45, 502-511. doi:https://doi.org/10.2337/dc21-1048
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial
Marta Garaulet; Jesus Lopez-Minguez; Hassan S. Dashti; Céline Vetter; Antonio Miguel Hernández-Martínez; Millán Pérez-Ayala; Juan Carlos Baraza; Wei Wang; Jose C. Florez; Frank A.J.L. Scheer; Richa Saxena
Diabetes Care January 2022, Vol.45, 512-519. doi:https://doi.org/10.2337/dc21-1314
Beliefs Around Hypoglycemia and Their Impacts on Hypoglycemia Outcomes in Individuals with Type 1 Diabetes and High Risks for Hypoglycemia Despite Using Advanced Diabetes Technologies
Yu Kuei Lin; Caroline R. Richardson; Iulia Dobrin; Melissa J. DeJonckheere; Kara Mizokami-Stout; Michael D. Fetters; James E. Aikens; Simon J. Fisher; Wen Ye; Rodica Pop-Busui
Diabetes Care January 2022, Vol.45, 520-528. doi:https://doi.org/10.2337/dc21-1285
Diabetes Distress in Young Adults With Youth-Onset Type 2 Diabetes: TODAY2 Study Results
Paula M. Trief; Diane Uschner; Melinda Tung; Marsha D. Marcus; Maria Rayas; Sarah MacLeish; Ryan Farrell; Joyce Keady; Lily Chao; Ruth S. Weinstock; on behalf of the TODAY Study Group
Diabetes Care January 2022, Vol.45, 529-537. doi:https://doi.org/10.2337/dc21-1689
Hypoglycemia Subtypes in Type 1 Diabetes: An Exploration of the Hypoglycemia Fear Survey-II
Rory H. Maclean; Peter Jacob; Pratik Choudhary; Simon R. Heller; Elena Toschi; Dulmini Kariyawasam; Augustin Brooks; Mike Kendall; Nicole de Zoysa; Linda A. Gonder-Frederick; Stephanie A. Amiel
Diabetes Care January 2022, Vol.45, 538-546. doi:https://doi.org/10.2337/dc21-1120
HbA1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial
Anita Y.M. Kwan; Hertzel C. Gerstein; Jan Basile; Denis Xavier; Juan M. Maldonado; Sohini Raha; Manige Konig
Diabetes Care January 2022, Vol.45, 547-554. doi:https://doi.org/10.2337/dc21-1160
The Gut Microbiome of Adults With Type 1 Diabetes and Its Association With the Host Glycemic Control
Smadar Shilo; Anastasia Godneva; Marianna Rachmiel; Tal Korem; Yuval Bussi; Dmitry Kolobkov; Tal Karady; Noam Bar; Bat Chen Wolf; Yitav Glantz-Gashai; Michal Cohen; Nehama Zuckerman Levin; Naim Shehadeh; Noah Gruber; Neriya Levran; Shlomit Koren; Adina Weinberger; Orit Pinhas-Hamiel; Eran Segal
Diabetes Care January 2022, Vol.45, 555-563. doi:https://doi.org/10.2337/dc21-1656
Circulating Fatty Acids and Genetic Predisposition to Type 2 Diabetes: Gene-Nutrient Interaction Analysis
Diabetes Care January 2022, Vol.45, 564-575. doi:https://doi.org/10.2337/dc21-2048
Prolonged Glycemic Adaptation Following Transition From a Low- to High-Carbohydrate Diet: A Randomized Controlled Feeding Trial
Lisa T. Jansen; Nianlan Yang; Julia M.W. Wong; Tapan Mehta; David B. Allison; David S. Ludwig; Cara B. Ebbeling
Diabetes Care March 2022, Vol.45, 576-584. doi:https://doi.org/10.2337/dc21-1970
Epidemiology / Health Services Research
Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes
Bruce A. Perkins; Ionut Bebu; Xiaoyu Gao; Amy B. Karger; Irl B. Hirsch; Harsha Karanchi; Mark E. Molitch; Bernard Zinman; John M. Lachin; Ian H. de Boer; for the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
Diabetes Care January 2022, Vol.45, 585-593. doi:https://doi.org/10.2337/dc21-1883
Cost-Related Medication Nonadherence in Adults With Diabetes in the United States: The National Health Interview Survey 2013–2018
Mohamad B. Taha; Javier Valero-Elizondo; Tamer Yahya; César Caraballo; Rohan Khera; Kershaw V. Patel; Hyeon Ju R. Ali; Garima Sharma; Elias Mossialos; Miguel Cainzos-Achirica; Khurram Nasir
Diabetes Care January 2022, Vol.45, 594-603. doi:https://doi.org/10.2337/dc21-1757
Three Sides to the Story: Adherence Trajectories During the First Year of SGLT2 Inhibitor Therapy Among Medicare Beneficiaries
Chelsea E. Hawley; Julie C. Lauffenburger; Julie M. Paik; Deborah J. Wexler; Seoyoung C. Kim; Elisabetta Patorno
Diabetes Care January 2022, Vol.45, 604-613. doi:https://doi.org/10.2337/dc21-1676
Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies
Elmar W. Tobi; Diana L. Juvinao-Quintero; Justiina Ronkainen; Raffael Ott; Rossella Alfano; Mickaël Canouil; Madelon L. Geurtsen; Amna Khamis; Leanne K. Küpers; Ives Y. Lim; Patrice Perron; Giancarlo Pesce; Johanna Tuhkanen; Anne P. Starling; Toby Andrew; Elisabeth Binder; Robert Caiazzo; Jerry K.Y. Chan; Romy Gaillard; Peter D. Gluckman; Elina Keikkala; Neerja Karnani; Sanna Mustaniemi; Tim S. Nawrot; François Pattou; Michelle Plusquin; Violeta Raverdy; Kok Hian Tan; Evangelia Tzala; Katri Raikkonen; Christiane Winkler; Anette-G. Ziegler; Isabella Annesi-Maesano; Luigi Bouchard; Yap Seng Chong; Dana Dabelea; Janine F. Felix; Barbara Heude; Vincent W.V. Jaddoe; Jari Lahti; Brigitte Reimann; Marja Vääräsmäki; Amélie Bonnefond; Philippe Froguel; Sandra Hummel; Eero Kajantie; Marjo-Riita Jarvelin; Regine P.M. Steegers-Theunissen; Caitlin G. Howe; Marie-France Hivert; Sylvain Sebert
Diabetes Care March 2022, Vol.45, 614-623. doi:https://doi.org/10.2337/dc21-1701
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
Laura M. Jacobsen; Kendra Vehik; Riitta Veijola; Katharina Warncke; Jorma Toppari; Andrea K. Steck; Patricia Gesualdo; Beena Akolkar; Markus Lundgren; William A. Hagopian; Jin-Xiong She; Marian Rewers; Anette-G. Ziegler; Jeffrey P. Krischer; Helena Elding Larsson; Michael J. Haller; the TEDDY Study Group
Diabetes Care January 2022, Vol.45, 624-633. doi:https://doi.org/10.2337/dc21-0422
Type 2 Diabetes, Glycemic Control, and Their Association With Dementia and Its Major Subtypes: Findings From the Swedish National Diabetes Register
Carlos A. Celis-Morales; Stefan Franzén; Katarina Eeg-Olofsson; Emma Nauclér; Ann-Marie Svensson; Soffia Gudbjornsdottir; Bjorn Eliasson; Naveed Sattar
Diabetes Care January 2022, Vol.45, 634-641. doi:https://doi.org/10.2337/dc21-0601
Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.
Lewis Pang; Kevin C. Colclough; Maggie H. Shepherd; Joanne McLean; Ewan R. Pearson; Sian Ellard; Andrew T. Hattersley; Beverley M. Shields
Diabetes Care January 2022, Vol.45, 642-649. doi:https://doi.org/10.2337/dc21-2056
Emerging Therapies: Drugs and Regimens
Real-world Evidence of Efficacy and Safety of SGLT2 Inhibitors as Adjunctive Therapy in Adults With Type 1 Diabetes: A European Two-Center Experience
Diabetes Care January 2022, Vol.45, 650-658. doi:https://doi.org/10.2337/dc21-1584
Emerging Technologies: Data Systems and Devices
Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study
Rose A. Gubitosi-Klug; Barbara H. Braffett; Ionut Bebu; Mary L. Johnson; Kaleigh Farrell; David Kenny; Victoria R. Trapani; Lynne Meadema-Mayer; Elsayed Z. Soliman; Rodica Pop-Busui; John M. Lachin; Richard M. Bergenstal; William V. Tamborlane; for the DCCT/EDIC Research Group
Diabetes Care January 2022, Vol.45, 659-665. doi:https://doi.org/10.2337/dc21-0629
Pathophysiology / Complications
Circulating Palmitoyl Sphingomyelin Is Associated With Cardiovascular Disease in Individuals With Type 2 Diabetes: Findings From the China Da Qing Diabetes Study
Yanyan Chen; Hongmei Jia; Xin Qian; Jinping Wang; Meng Yu; Qiuhong Gong; Yali An; Hui Li; Sidong Li; Na Shi; Zhongmei Zou; Guangwei Li
Diabetes Care March 2022, Vol.45, 666-673. doi:https://doi.org/10.2337/dc21-1520
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts
Daniel DiCorpo; Jessica LeClair; Joanne B. Cole; Chloé Sarnowski; Fariba Ahmadizar; Lawrence F. Bielak; Anneke Blokstra; Erwin P. Bottinger; Layal Chaker; Yii-Der I. Chen; Ye Chen; Paul S. de Vries; Tariq Faquih; Mohsen Ghanbari; Valborg Gudmundsdottir; Xiuqing Guo; Natalie R. Hasbani; Dorina Ibi; M. Arfan Ikram; Maryam Kavousi; Hampton L. Leonard; Aaron Leong; Josep M. Mercader; Alanna C. Morrison; Girish N. Nadkarni; Mike A. Nalls; Raymond Noordam; Michael Preuss; Jennifer A. Smith; Stella Trompet; Petra Vissink; Jie Yao; Wei Zhao; Eric Boerwinkle; Mark O. Goodarzi; Vilmundur Gudnason; J. Wouter Jukema; Sharon L.R. Kardia; Ruth J.F. Loos; Ching-Ti Liu; Alisa K. Manning; Dennis Mook-Kanamori; James S. Pankow; H. Susan J. Picavet; Naveed Sattar; Eleanor M. Simonsick; W.M. Monique Verschuren; Ko Willems van Dijk; Jose C. Florez; Jerome I. Rotter; James B. Meigs; Josée Dupuis; Miriam S. Udler
Diabetes Care January 2022, Vol.45, 674-683. doi:https://doi.org/10.2337/dc21-1395
Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes
Diabetes Care January 2022, Vol.45, 684-691. doi:https://doi.org/10.2337/dc21-2196
Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19
Alexi Vasbinder; Elizabeth Anderson; Husam Shadid; Hanna Berlin; Michael Pan; Tariq U. Azam; Ibrahim Khaleel; Kishan Padalia; Chelsea Meloche; Patrick O’Hayer; Erinleigh Michaud; Tonimarie Catalan; Rafey Feroze; Pennelope Blakely; Christopher Launius; Yiyuan Huang; Lili Zhao; Lynn Ang; Monica Mikhael; Kara Mizokami-Stout; Subramaniam Pennathur; Matthias Kretzler; Sven H. Loosen; Athanasios Chalkias; Frank Tacke; Evangelos J. Giamarellos-Bourboulis; Jochen Reiser; Jesper Eugen-Olsen; Eva L. Feldman; Rodica Pop-Busui; Salim S. Hayek; on behalf of the ISIC Study Group
Diabetes Care January 2022, Vol.45, 692-700. doi:https://doi.org/10.2337/dc21-2102
Shortened Leukocyte Telomere Length Is Associated With Glycemic Progression in Type 2 Diabetes: A Prospective and Mendelian Randomization Analysis
Feifei Cheng; Andrea O. Luk; Mai Shi; Chuiguo Huang; Guozhi Jiang; Aimin Yang; Hongjiang Wu; Cadmon K.P. Lim; Claudia H.T. Tam; Baoqi Fan; Eric S.H. Lau; Alex C.W. Ng; Kwun Kiu Wong; Luke Carroll; Heung Man Lee; Alice P. Kong; Anthony C. Keech; Elaine Chow; Mugdha V. Joglekar; Stephen K.W. Tsui; Wing Yee So; Hon Cheong So; Anandwardhan A. Hardikar; Alicia J. Jenkins; Juliana C.N. Chan; Ronald C.W. Ma
Diabetes Care January 2022, Vol.45, 701-709. doi:https://doi.org/10.2337/dc21-1609
Cardiovascular and Metabolic Risk
Prediction of Major Adverse Cardiovascular Events From Retinal, Clinical, and Genomic Data in Individuals With Type 2 Diabetes: A Population Cohort Study
Ify R. Mordi; Emanuele Trucco; Mohammad Ghouse Syed; Tom MacGillivray; Adi Nar; Yu Huang; Gittu George; Stephen Hogg; Venkatesan Radha; Vijayaraghavan Prathiba; Ranjit Mohan Anjana; Viswanathan Mohan; Colin N.A. Palmer; Ewan R. Pearson; Chim C. Lang; Alex S.F. Doney; for the INSPIRED Investigators
Diabetes Care January 2022, Vol.45, 710-716. doi:https://doi.org/10.2337/dc21-1124
Polygenic Prediction of Type 2 Diabetes in Africa
Tinashe Chikowore; Kenneth Ekoru; Marijana Vujkovi; Dipender Gill; Fraser Pirie; Elizabeth Young; Manjinder S. Sandhu; Mark McCarthy; Charles Rotimi; Adebowale Adeyemo; Ayesha Motala; Segun Fatumo
Diabetes Care January 2022, Vol.45, 717-723. doi:https://doi.org/10.2337/dc21-0365
Risk of Developing Type 2 Diabetes in Individuals With a Psychiatric Disorder: A Nationwide Register-Based Cohort Study
Nanna Lindekilde; Stine H. Scheuer; Lars J. Diaz; Katrine H. Rubin; Oleguer Plana-Ripoll; Jan Erik Henriksen; Mathias Lasgaard; Gregers S. Andersen; Frans Pouwer
Diabetes Care January 2022, Vol.45, 724-733. doi:https://doi.org/10.2337/dc21-1864
Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With Type 1 Diabetes
Raija Lithovius; Anni A. Antikainen; Stefan Mutter; Erkka Valo; Carol Forsblom; Valma Harjutsalo; Niina Sandholm; Per-Henrik Groop; on behalf of the FinnDiane Study Group
Diabetes Care January 2022, Vol.45, 734-741. doi:https://doi.org/10.2337/dc21-0974
Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial
Diabetes Care January 2022, Vol.45, 742-749. doi:https://doi.org/10.2337/dc21-1206
Novel Communications in Diabetes
Continuous Glucose Monitoring Initiation Within First Year of Type 1 Diabetes Diagnosis Is Associated With Improved Glycemic Outcomes: 7-Year Follow-Up Study
Diabetes Care January 2022, Vol.45, 750-753. doi:https://doi.org/10.2337/dc21-2004
Impact of Diabetes Duration on Functional and Clinical Status in Older Adults With Type 1 Diabetes
Medha Munshi; Christine Slyne; Atif Adam; Dai’Quann Davis; Amy Michals; Astrid Atakov-Castillo; Katie Weinger; Elena Toschi
Diabetes Care January 2022, Vol.45, 754-757. doi:https://doi.org/10.2337/dc21-2000
Errata
Erratum. 11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes—2022. Diabetes Care 2022;45(Suppl. 1): S175–S184
Diabetes Care December 2021, Vol.45, 758. doi:https://doi.org/10.2337/dc22-er03
Erratum. Rationale and Design of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Diabetes Care 2013;36:2254–2261
David M. Nathan; John B. Buse; Steven E. Kahn; Heidi Krause-Steinrauf; Mary E. Larkin; Myrlene Staten; Deborah Wexler; John M. Lachin; the GRADE Study Research Group
Diabetes Care January 2022, Vol.45, 759. doi:https://doi.org/10.2337/dc22-er03a
Erratum. Characteristics of the Gut Microbiota and Metabolism in Patients With Latent Autoimmune Diabetes in Adults: A Case-Control Study. Diabetes Care 2021;44:2738–2746
Yuanyuan Fang; Chenhong Zhang; Hongcai Shi; Wei Wei; Jing Shang; Ruizhi Zheng; Lu Yu; Pingping Wang; Junpeng Yang; Xinru Deng; Yun Zhang; Shasha Tang; Xiaoyang Shi; Yalei Liu; Huihui Yang; Qian Yuan; Rui Zhai; Huijuan Yuan
Diabetes Care January 2022, Vol.45, 761. doi:https://doi.org/10.2337/dc22-er03c
Issues and Events
e-Letters
Observations
Economic Disparities Among Pediatric Diabetic Ketoacidosis Readmissions in the U.S.
Diabetes Care January 2022, Vol.45, e46-e47. doi:https://doi.org/10.2337/dc21-1776
Improving the Prediction of Type 1 Diabetes Across Ancestries
John S. Kaddis; Daniel J. Perry; Anh Nguyet Vu; Stephen S. Rich; Mark A. Atkinson; Desmond A. Schatz; Bart O. Roep; Todd M. Brusko
Diabetes Care January 2022, Vol.45, e48-e50. doi:https://doi.org/10.2337/dc21-1254
Gender Differences in Strategies to Prevent Physical Activity–Related Hypoglycemia in Patients With Type 1 Diabetes: A BETTER Study
Melinda S. Prévost; Remi Rabasa-Lhoret; Meryem K. Talbo; Jane E. Yardley; Emily G. Curry; Anne-Sophie Brazeau
Diabetes Care January 2022, Vol.45, e51-e53. doi:https://doi.org/10.2337/dc21-1899
Medication Use Among U.S. Adults After Bariatric Surgery: A Population-Based Analysis of NHANES 2015–2018
Diabetes Care January 2022, Vol.45, e54-e55. doi:https://doi.org/10.2337/dc21-2285
Comments and Responses
Comment on Gange et al. Incidence of Proliferative Diabetic Retinopathy and Other Neovascular Sequelae at 5 Years Following Diagnosis of Type 2 Diabetes. Diabetes Care 2021;44:2518–2526
Vincent Rigalleau; Alice Larroumet; Kamel Mohammedi; Laurence Baillet-Blanco; Marie Monlun; Marie-Noelle Delyfer; Jean-François Korobelnik; Ninon Foussard
Diabetes Care March 2022, Vol.45, e60. doi:https://doi.org/10.2337/dc21-2254
Comment on Fahrmann et al. Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2021;44;2132–2139
José-Miguel González-Clemente; Gemma Llauradó; Ana Romero; Olga Giménez-Palop; Eugenio Berlanga; Joan Vendrell
Diabetes Care March 2022, Vol.45, e63-e64. doi:https://doi.org/10.2337/dc21-2262
Response to Comment on Fahrmann et al. Modification of the Association Between Severe Hypoglycemia and Ischemic Heart Disease by Surrogates of Vascular Damage Severity in Type 1 Diabetes During ∼30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2021;44;2132–2139
Diabetes Care March 2022, Vol.45, e65-e66. doi:https://doi.org/10.2337/dci21-0058
Comment on Oosterwijk et al. High-Normal Protein Intake Is Not Associated With Faster Renal Function Deterioration in Patients With Type 2 Diabetes: A Prospective Analysis in the DIALECT Cohort. Diabetes Care 2022;45:35–41
Diabetes Care March 2022, Vol.45, e67-e68. doi:https://doi.org/10.2337/dc21-2393
Response to Comment on Oosterwijk et al. High-Normal Protein Intake Is Not Associated With Faster Renal Function Deterioration in Patients With Type 2 Diabetes: A Prospective Analysis in the DIALECT Cohort. Diabetes Care 2022;45:35–41
Diabetes Care March 2022, Vol.45, e69. doi:https://doi.org/10.2337/dci21-0062
Comment on Lachin et al. The Beneficial Effects of Earlier Versus Later Implementation of Intensive Therapy in Type 1 Diabetes. Diabetes Care 2021;44:2225–2230
Diabetes Care March 2022, Vol.45, e70-e71. doi:https://doi.org/10.2337/dc21-2372
Comment on Sjöholm et al. Association of Bariatric Surgery With Cancer Incidence in Patients With Obesity and Diabetes: Long-term Results From the Swedish Obese Subjects Study. Diabetes Care 2022;45:444–450
Vincent Rigalleau; Marie-Amélie Barbet-Massin; Alice Larroumet; Kamel Mohammedi; Laurence Baillet-Blanco; Marie Monlun; Blandine Cherifi; Ninon Foussard
Diabetes Care March 2022, Vol.45, e72. doi:https://doi.org/10.2337/dc21-2477
