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Beverley M. Shields
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Journal Articles

Age of Diagnosis Does Not Alter the Presentation or Progression of Robustly Defined Adult-Onset Type 1 Diabetes

Nicholas J. Thomas, Anita V. Hill, Colin M. Dayan, Richard A. Oram, Timothy J. McDonald, Beverley M. Shields, Angus G. Jones, StartRight Study Group, Godwin Simon, Dr, Angelo Ramos, Andrea Norris, Dr, Kai Tan, Dr, Parth Narendran, Dr, Shenaz Ramtoola, Dr, Amar Ali, Dr, Moulinath Banerjee, Dr, Augustin Brooks, Dr, Ali Chakera, Dr, Andrew Johnson, Dr, Danijela Tatovic, Dr, Chitrabhanu Ballav, Dr, Colin Dayan, Prof, Sunil Nair, Dr, Francis Game, Prof, Susan Beames, Gerry Rayman, Prof, Marie Snell, Susie Butler, Sarah Beck, Janet Beecham, John Wilding, Prof, Sam Rice, Dr, Mimi Chen, Dr, Athinyaa Thiraviaraj, Dr, Siva Sivappriyan, Dr, Basil Issa, Dr, Asif Humayun, Dr, Rebecca Hinch, Leena Krishnan, Dr, Khin Swe Myint, Dr, Charles Fox, Dr, Jennifer Prouten, Dr, Mike Sampson, Prof, Peter Mansell, Dr, Carolyn Chee, Dr, Katherine Owen, Dr, Ioannis Dimitropoulis, Dr, Michael Cummings, Prof, Foteini Kavourra, Dr, Adrian Heald, Dr, Simon Heller, Prof, Sarbpreet Sihota, Dr, Vakkat Muraleedharan, Dr, Tara Watson, Dr, Hermione Price, Dr, Roger Whittaker, Sarah Orme, Ben Field, Dr, Stephen Bain, Prof, Beas Battacharya, Dr, Lesley Haxton, Suzannah Pegler, Catherine Thompson, Rob Andrew, Prof, Jamie Smith, Dr, Duncan Browne, Dr, Steve Creely, Dr, Rahul Yadav, Dr, Rakhi Kakad, Dr, Ken Laji, Dr, Mohit Kumar, Dr, Alirezi Mohammadi, Dr, James Young, Dr, Seshadri Pramodh, Dr, Vijay Jayagopal, Dr, Angus Jones, Dr, Anita Hill, Robert Bolt, Suzanne Hammersley, Migaila Aldred, Anna Steele, Peter Tippett
Journal: Diabetes Care
Diabetes Care 2023;46(6):1156–1163
DOI: https://doi.org/10.2337/dc22-2159
Published: 21 February 2023
View article titled, Age of Diagnosis Does Not Alter the Presentation or Progression of Robustly Defined Adult-Onset Type 1 Diabetes
Click here to open pdf in another window PDF for Age of Diagnosis Does Not Alter the Presentation or Progression of Robustly Defined Adult-Onset Type 1 Diabetes
Journal Articles

Routine Islet Autoantibody Testing in Clinically Diagnosed Adult-Onset Type 1 Diabetes Can Help Identify Misclassification and the Possibility of Successful Insulin Cessation

Russell J. Eason, Nicholas J. Thomas, Anita V. Hill, Bridget A. Knight, Alice Carr, Andrew T. Hattersley, Timothy J. McDonald, Beverley M. Shields, Angus G. Jones, for the StartRight Study Group , Godwin Simon, Angelo Ramos, Andrea Norris, Kai Tan, Parth Narendran, Shenaz Ramtoola, Amar Ali, Moulinath Banerjee, Augustin Brooks, Ali Chakera, Andrew Johnson, Danijela Tatovic, Chitrabhanu Ballav, Colin Dayan, Sunil Nair, Frances Game, Angus Jones, Susan Beames, Gerry Rayman, Marie Snell, Susie Butler, Sarah Beck, Janet Beecham, John Wilding, Sam Rice, Mimi Chen, Athinyaa Thiraviaraj, Siva Sivappriyan, Basil Issa, Asif Humayun, Rebecca Hinch, Leena Krishnan, Khin Swe Myint, Charles Fox, Jennifer Prouten, Mike Sampson, Peter Mansell, Carolyn Chee, Katharine Owen, Ioannis Dimitropoulis, Michael Cummings, Foteini Kavourra, Adrian Heald, Simon Heller, Sarbpreet Sihota, Vakkat Muraleedharan, Tara Watson, Hermione Price, Roger Whittaker, Sarah Orme, Ben Field, Stephen Bain, Beas Battacharya, Lesley Haxton, Suzannah Pegler, Catherine Thompson, Rob Andrew, Jamie Smith, Duncan Browne, Steve Creely, Rahul Yadav, Rakhi Kakad, Ken Laji, Mohit Kumar, Alirezi Mohammadi, James Young, Seshadri Pramodh, Vijay Jayagopal
Journal: Diabetes Care
Diabetes Care 2022;45(12):2844–2851
DOI: https://doi.org/10.2337/dc22-0623
Published: 07 October 2022
View article titled, Routine Islet Autoantibody Testing in Clinically Diagnosed Adult-Onset Type 1 Diabetes Can Help Identify Misclassification and the Possibility of Successful Insulin Cessation
Click here to open pdf in another window PDF for Routine Islet Autoantibody Testing in Clinically Diagnosed Adult-Onset Type 1 Diabetes Can Help Identify Misclassification and the Possibility of Successful Insulin Cessation
Journal Articles

Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.

Lewis Pang, Kevin C. Colclough, Maggie H. Shepherd, Joanne McLean, Ewan R. Pearson, Sian Ellard, Andrew T. Hattersley, Beverley M. Shields
Journal: Diabetes Care
Diabetes Care 2022;45(3):642–649
DOI: https://doi.org/10.2337/dc21-2056
Published: 21 January 2022
View article titled, Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.
Click here to open pdf in another window PDF for Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.
Journal Articles

Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes

Angus G. Jones, Timothy J. McDonald, Beverley M. Shields, William Hagopian, Andrew T. Hattersley
Journal: Diabetes Care
Diabetes Care 2021;44(6):1243–1251
DOI: https://doi.org/10.2337/dc20-2834
Published: 18 June 2021
View article titled, Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes
Click here to open pdf in another window PDF for Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes
Journal Articles

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

Kashyap A. Patel, Michael N. Weedon, Beverley M. Shields, Ewan R. Pearson, Andrew T. Hattersley, Timothy J. McDonald
Journal: Diabetes Care
Diabetes Care 2019;42(2):e16–e17
DOI: https://doi.org/10.2337/dc18-0373
Published: 08 November 2018
View article titled, Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes
Click here to open pdf in another window PDF for Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes
Journal Articles

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Anita L. Grubb, Timothy J. McDonald, Femke Rutters, Louise A. Donnelly, Andrew T. Hattersley, Richard A. Oram, Colin N.A. Palmer, Amber A. van der Heijden, Fiona Carr, Petra J.M. Elders, Mike N. Weedon, Roderick C. Slieker, Leen M. ’t Hart, Ewan R. Pearson, Beverley M. Shields, Angus G. Jones
Journal: Diabetes Care
Diabetes Care 2019;42(2):208–214
DOI: https://doi.org/10.2337/dc18-0431
Published: 23 October 2018
View article titled, A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy
Click here to open pdf in another window PDF for A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy
Includes: Supplementary data
Journal Articles

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data

John M. Dennis, William E. Henley, Michael N. Weedon, Mike Lonergan, Lauren R. Rodgers, Angus G. Jones, William T. Hamilton, Naveed Sattar, Salim Janmohamed, Rury R. Holman, Ewan R. Pearson, Beverley M. Shields, Andrew T. Hattersley, MASTERMIND Consortium, Catherine Angwin, Kennedy J. Cruickshank, Andrew J. Farmer, Stephen C.L. Gough, Alastair M. Gray, Christopher Hyde, Christopher Jennison, Mark Walker
Journal: Diabetes Care
Diabetes Care 2018;41(9):1844–1853
DOI: https://doi.org/10.2337/dc18-0344
Published: 02 August 2018
View article titled, Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data
Click here to open pdf in another window PDF for Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data
Includes: Supplementary data
Journal Articles

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase

Beverley M. Shields, Timothy J. McDonald, Richard Oram, Anita Hill, Michelle Hudson, Pia Leete, Ewan R. Pearson, Sarah J. Richardson, Noel G. Morgan, Andrew T. Hattersley, The TIGI Consortium, Bart O. Roep, Tim I. Tree, Suzy Hammersley, Robert Bolt, Anita V. Hill
Journal: Diabetes Care
Diabetes Care 2018;41(7):1486–1492
DOI: https://doi.org/10.2337/dc18-0465
Published: 07 June 2018
View article titled, C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase
Click here to open pdf in another window PDF for C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase
Includes: Supplementary data
Journal Articles

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy

John M. Dennis, Beverley M. Shields, Anita V. Hill, Bridget A. Knight, Timothy J. McDonald, Lauren R. Rodgers, Michael N. Weedon, William E. Henley, Naveed Sattar, Rury R. Holman, Ewan R. Pearson, Andrew T. Hattersley, Angus G. Jones
Journal: Diabetes Care
Diabetes Care 2018;41(4):705–712
DOI: https://doi.org/10.2337/dc17-1827
Published: 31 January 2018
View article titled, Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy
Click here to open pdf in another window PDF for Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy
Includes: Supplementary data
Journal Articles

Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients

Beverley M. Shields, Maggie Shepherd, Michelle Hudson, Timothy J. McDonald, Kevin Colclough, Jaime Peters, Bridget Knight, Chris Hyde, Sian Ellard, Ewan R. Pearson, Andrew T. Hattersley
Journal: Diabetes Care
Diabetes Care 2017;40(8):1017–1025
DOI: https://doi.org/10.2337/dc17-0224
Published: 11 July 2017
View article titled, Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients
Click here to open pdf in another window PDF for Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients
Includes: Supplementary data
Journal Articles

Markers of β-Cell Failure Predict Poor Glycemic Response to GLP-1 Receptor Agonist Therapy in Type 2 Diabetes

Angus G. Jones, Timothy J. McDonald, Beverley M. Shields, Anita V. Hill, Christopher J. Hyde, Bridget A. Knight, Andrew T. Hattersley
Journal: Diabetes Care
Diabetes Care 2016;39(2):250–257
DOI: https://doi.org/10.2337/dc15-0258
Published: 04 August 2015
View article titled, Markers of β-Cell Failure Predict Poor Glycemic Response to GLP-1 Receptor Agonist Therapy in Type 2 Diabetes
Click here to open pdf in another window PDF for Markers of β-Cell Failure Predict Poor Glycemic Response to GLP-1 Receptor Agonist Therapy in Type 2 Diabetes
Includes: Supplementary data
Journal Articles

Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors

Richard A. Oram, Timothy J. McDonald, Beverley M. Shields, Michelle M. Hudson, Maggie H. Shepherd, Suzanne Hammersley, Ewan R. Pearson, Andrew T. Hattersley, on behalf of the UNITED Team
Journal: Diabetes Care
Diabetes Care 2015;38(2):323–328
DOI: https://doi.org/10.2337/dc14-0871
Published: 17 December 2014
View article titled, Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors
Click here to open pdf in another window PDF for Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors
Includes: Supplementary data
Journal Articles

Effect of the Holiday Season in Patients With Diabetes: Glycemia and Lipids Increase Postholiday, but the Effect Is Small and Transient

Angus G. Jones, Timothy J. McDonald, Andrew T. Hattersley, Beverley M. Shields
Journal: Diabetes Care
Diabetes Care 2014;37(5):e98–e99
DOI: https://doi.org/10.2337/dc13-2353
Published: 10 April 2014
View article titled, Effect of the Holiday Season in Patients With Diabetes: Glycemia and Lipids Increase Postholiday, but the Effect Is Small and Transient
Click here to open pdf in another window PDF for Effect of the Holiday Season in Patients With Diabetes: Glycemia and Lipids Increase Postholiday, but the Effect Is Small and Transient
Journal Articles

Response to Comment on: Besser et al. Lessons From the Mixed-Meal Tolerance Test: Use of 90-Minute and Fasting C-Peptide in Pediatric Diabetes. Diabetes Care 2013;36:195–201

Beverley M. Shields, PHD, William Henley, PHD, Rachel E.J. Besser, PHD, Andrew T. Hattersley, DM, Johnny Ludvigsson, PHD
Journal: Diabetes Care
Diabetes Care 2013;36(12):e222
DOI: https://doi.org/10.2337/dc13-0609
Published: 13 November 2013
View article titled, Response to Comment on: Besser et al. Lessons From the Mixed-Meal Tolerance Test: Use of 90-Minute and Fasting C-Peptide in Pediatric Diabetes. Diabetes Care 2013;36:195–201
Click here to open pdf in another window PDF for Response to Comment on: Besser et al. Lessons From the Mixed-Meal Tolerance Test: Use of 90-Minute and Fasting C-Peptide in Pediatric Diabetes. Diabetes Care 2013;36:195–201
Includes: Supplementary data
Journal Articles

Lessons From the Mixed-Meal Tolerance Test: Use of 90-minute and fasting C-peptide in pediatric diabetes

Rachel E.J. Besser, PHD, Beverley M. Shields, PHD, Rosaura Casas, PHD, Andrew T. Hattersley, DM, Johnny Ludvigsson, MD
Journal: Diabetes Care
Diabetes Care 2013;36(2):195–201
DOI: https://doi.org/10.2337/dc12-0836
Published: 17 January 2013
View article titled, Lessons From the Mixed-Meal Tolerance Test: <span class="subtitle">Use of 90-minute and fasting C-peptide in pediatric diabetes</span>
Click here to open pdf in another window PDF for Lessons From the Mixed-Meal Tolerance Test: <span class="subtitle">Use of 90-minute and fasting C-peptide in pediatric diabetes</span>
Includes: Supplementary data
Journal Articles

High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes

Tim J. McDonald, MSC, Beverley M. Shields, PHD, Jane Lawry, BSC, Katharine R. Owen, MD, Anna L. Gloyn, DPHIL, Sian Ellard, PHD, Andrew T. Hattersley, DM
Journal: Diabetes Care
Diabetes Care 2011;34(8):1860–1862
DOI: https://doi.org/10.2337/dc11-0323
Published: 16 July 2011
View article titled, High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes
Click here to open pdf in another window PDF for High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes
Includes: Supplementary data
Journal Articles

Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes

Rachel E.J. Besser, MBBS, Johnny Ludvigsson, PHD, Angus G. Jones, MBBS, Timothy J. McDonald, MSC, Beverley M. Shields, PHD, Bridget A. Knight, PHD, Andrew T. Hattersley, DM
Journal: Diabetes Care
Diabetes Care 2011;34(3):607–609
DOI: https://doi.org/10.2337/dc10-2114
Published: 17 February 2011
View article titled, Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes
Click here to open pdf in another window PDF for Urine C-Peptide Creatinine Ratio Is a Noninvasive Alternative to the Mixed-Meal Tolerance Test in Children and Adults With Type 1 Diabetes
Includes: Supplementary data
Journal Articles

Urinary C-Peptide Creatinine Ratio Is a Practical Outpatient Tool for Identifying Hepatocyte Nuclear Factor 1-α/Hepatocyte Nuclear Factor 4-α Maturity-Onset Diabetes of the Young From Long-Duration Type 1 Diabetes

Rachel E.J. Besser, MBBS, Maggie H. Shepherd, PHD, Timothy J. McDonald, MSC, Beverley M. Shields, PHD, Bridget A. Knight, PHD, Sian Ellard, PHD, Andrew T. Hattersley, DM
Journal: Diabetes Care
Diabetes Care 2011;34(2):286–291
DOI: https://doi.org/10.2337/dc10-1293
Published: 20 January 2011
View article titled, Urinary C-Peptide Creatinine Ratio Is a Practical Outpatient Tool for Identifying Hepatocyte Nuclear Factor 1-α/Hepatocyte Nuclear Factor 4-α Maturity-Onset Diabetes of the Young From Long-Duration Type 1 Diabetes
Click here to open pdf in another window PDF for Urinary C-Peptide Creatinine Ratio Is a Practical Outpatient Tool for Identifying Hepatocyte Nuclear Factor 1-α/Hepatocyte Nuclear Factor 4-α Maturity-Onset Diabetes of the Young From Long-Duration Type 1 Diabetes
Includes: Supplementary data
Journal Articles

Mutations in the Glucokinase Gene of the Fetus Result in Reduced Placental Weight

Beverley M. Shields, PHD, Gill Spyer, MD, MRCP, Annabelle S. Slingerland, MD, MPH, Bridget A. Knight, PHD, Sian Ellard, PHD, MRCPATH, Penelope M. Clark, PHD, FRCPATH, Sylvie Hauguel-de Mouzon, PHD, Andrew T. Hattersley, DM, FRCP
Journal: Diabetes Care
Diabetes Care 2008;31(4):753–757
DOI: https://doi.org/10.2337/dc07-1750
Published: 01 April 2008
View article titled, Mutations in the Glucokinase Gene of the Fetus Result in Reduced Placental Weight
Click here to open pdf in another window PDF for Mutations in the Glucokinase Gene of the Fetus Result in Reduced Placental Weight
Journal Articles

Effective Treatment With Oral Sulfonylureas in Patients With Diabetes Due to Sulfonylurea Receptor 1 (SUR1) Mutations

Meena Rafiq, Sarah E. Flanagan, BSC, Ann-Marie Patch, PHD, Beverley M. Shields, PHD, Sian Ellard, PHD, MRCPATH, Andrew T. Hattersley, FRCP, DM, The Neonatal Diabetes International Collaborative Group
Journal: Diabetes Care
Diabetes Care 2008;31(2):204–209
DOI: https://doi.org/10.2337/dc07-1785
Published: 01 February 2008
View article titled, Effective Treatment With Oral Sulfonylureas in Patients With Diabetes Due to Sulfonylurea Receptor 1 (SUR1) Mutations
Click here to open pdf in another window PDF for Effective Treatment With Oral Sulfonylureas in Patients With Diabetes Due to Sulfonylurea Receptor 1 (SUR1) Mutations