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Journal Articles

SGLT2 Inhibitor Dapagliflozin Increases Skeletal Muscle and Brain Fatty Acid Uptake in Individuals With Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Positron Emission Tomography Study

Aino Latva-Rasku, Eleni Rebelos, Jouni Tuisku, Richard Aarnio, Achol Bhowmik, Helmi Keskinen, Sanna Laurila, Minna Lahesmaa-Hatting, Laura Pekkarinen, Henrik Isackson, Anna K. Kirjavainen, Jukka Koffert, Kerstin Heurling, Lauri Nummenmaa, Ele Ferrannini, Jonas Oldgren, Jan Oscarsson, Pirjo Nuutila
Journal: Diabetes Care
Diabetes Care 2024;47(9):1630–1637
https://doi.org/10.2337/dc24-0470
Published: 28 June 2024
View article titled, SGLT2 Inhibitor Dapagliflozin Increases Skeletal Muscle and Brain Fatty Acid Uptake in Individuals With Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Positron Emission Tomography Study
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Journal Articles

High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors

Elena Fortin, Beatrice Campi, Ele Ferrannini, Andrea Mari, Linda G. Mellbin, Anna Norhammar, Per Näsman, Lars Rydén, Alessandro Saba, Giulia Ferrannini
Journal: Diabetes Care
Diabetes Care 2024;47(2):246–251
https://doi.org/10.2337/dc23-0870
Published: 06 December 2023
View article titled, High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors
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Journal Articles

Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS)

Ele Ferrannini, Simona Baldi, Tiziana Scozzaro, Vasilis Tsimihodimos, Fisseha Tesfaye, Wayne Shaw, Norman Rosenthal, Gemma A. Figtree, Bruce Neal, Kenneth W. Mahaffey, Vlado Perkovic, Michael K. Hansen
Journal: Diabetes Care
Diabetes Care 2022;45(8):1893–1899
https://doi.org/10.2337/dc21-2398
Published: 26 July 2022
View article titled, Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS)
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Journal Articles

Metabolic, Intestinal, and Cardiovascular Effects of Sotagliflozin Compared With Empagliflozin in Patients With Type 2 Diabetes: A Randomized, Double-Blind Study

Maximilian G. Posch, Niklas Walther, Ele Ferrannini, David R. Powell, Phillip Banks, Suman Wason, Raphael Dahmen
Journal: Diabetes Care
Diabetes Care 2022;45(9):2118–2126
https://doi.org/10.2337/dc21-2166
Published: 11 July 2022
View article titled, Metabolic, Intestinal, and Cardiovascular Effects of Sotagliflozin Compared With Empagliflozin in Patients With Type 2 Diabetes: A Randomized, Double-Blind Study
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Journal Articles

New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms

Roberto Bizzotto, Domenico Tricò, Andrea Natali, Amalia Gastaldelli, Elza Muscelli, Ralph A. De Fronzo, Silva Arslanian, Ele Ferrannini, Andrea Mari
Journal: Diabetes Care
Diabetes Care 2021;44(9):2115–2123
https://doi.org/10.2337/dc21-0545
Published: 26 August 2021
View article titled, New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms
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Journal Articles

Response to Comment on Ferrannini and Rosenstock. Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye? Diabetes Care 2021;44:641–646

Ele Ferrannini, Julio Rosenstock
Journal: Diabetes Care
Diabetes Care 2021;44(7):e155
https://doi.org/10.2337/dci21-0014
Published: 20 July 2021
View article titled, Response to Comment on Ferrannini and Rosenstock. Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye? Diabetes Care 2021;44:641–646
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Journal Articles

Erratum. Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye? Diabetes Care 2021;44: 641–646

Ele Ferrannini, Julio Rosenstock
Journal: Diabetes Care
Diabetes Care 2021;44(6):1454
https://doi.org/10.2337/dc21-er06
Published: 23 April 2021
View article titled, Erratum. Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye? Diabetes Care 2021;44: 641–646
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Journal Articles

Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye?

Ele Ferrannini, Julio Rosenstock
Journal: Diabetes Care
Diabetes Care 2021;44(3):641–646
https://doi.org/10.2337/dc20-0913
Published: 11 February 2021
View article titled, Clinical Translation of Cardiovascular Outcome Trials in Type 2 Diabetes: Is There More or Is There Less Than Meets the Eye?
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Journal Articles

Erratum. Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study. Diabetes Care 2020;43: 843–851

Giulia Ferrannini, Maria Laura Manca, Marco Magnoni, Felicita Andreotti, Daniele Andreini, Roberto Latini, Attilio Maseri, Aldo P. Maggioni, Rachel M. Ostroff, Stephen A. Williams, Ele Ferrannini
Journal: Diabetes Care
Diabetes Care 2021;44(4):1071
https://doi.org/10.2337/dc21-er04a
Published: 26 January 2021
View article titled, Erratum. Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study. Diabetes Care 2020;43: 843–851
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Journal Articles

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort

Eleni Rebelos, Marco Bucci, Tomi Karjalainen, Vesa Oikonen, Alessandra Bertoldo, Jarna C. Hannukainen, Kirsi A. Virtanen, Aino Latva-Rasku, Jussi Hirvonen, Ilkka Heinonen, Riitta Parkkola, Markku Laakso, Ele Ferrannini, Patricia Iozzo, Lauri Nummenmaa, Pirjo Nuutila
Journal: Diabetes Care
Diabetes Care 2021;44(3):788–794
https://doi.org/10.2337/dc20-1549
Published: 14 January 2021
View article titled, Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort
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Journal Articles

Erratum. Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2020;43: 1813–1821

Christopher K. Rayner, Linda E. Watson, Liza K. Phillips, Kylie Lange, Michelle J. Bound, Jacqueline Grivell, Tongzhi Wu, Karen L. Jones, Michael Horowitz, Ele Ferrannini, Domenico Tricò, Silvia Frascerra, Andrea Mari, Andrea Natali
Journal: Diabetes Care
Diabetes Care 2021;44(1):297
https://doi.org/10.2337/dc21-er01
Published: 09 November 2020
View article titled, Erratum. Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2020;43: 1813–1821
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Journal Articles

Mechanisms of Sodium–Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics

Ele Ferrannini, Ashwin C. Murthy, Yong-ho Lee, Elza Muscelli, Sophie Weiss, Rachel M. Ostroff, Naveed Sattar, Stephen A. Williams, Peter Ganz
Journal: Diabetes Care
Diabetes Care 2020;43(9):2183–2189
https://doi.org/10.2337/dc20-0456
Published: 11 June 2020
View article titled, Mechanisms of Sodium–Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics
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Journal Articles

Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial

Christopher K. Rayner, Linda E. Watson, Liza K. Phillips, Kylie Lange, Michelle J. Bound, Jacqueline Grivell, Tongzhi Wu, Karen L. Jones, Michael Horowitz, Ele Ferrannini, Domenico Tricò, Silvia Frascerra, Andrea Mari, Andrea Natali
Journal: Diabetes Care
Diabetes Care 2020;43(8):1813–1821
https://doi.org/10.2337/dc20-0190
Published: 29 May 2020
View article titled, Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial
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Journal Articles

Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study

Giulia Ferrannini, Maria Laura Manca, Marco Magnoni, Felicita Andreotti, Daniele Andreini, Roberto Latini, Attilio Maseri, Aldo P. Maggioni, Rachel M. Ostroff, Stephen A. Williams, Ele Ferrannini
Journal: Diabetes Care
Diabetes Care 2020;43(4):843–851
https://doi.org/10.2337/dc19-1902
Published: 27 January 2020
View article titled, Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
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Includes: Supplementary data
Journal Articles

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium–Glucose Cotransporter (SGLT) Inhibitors

Thomas Danne, Satish Garg, Anne L. Peters, John B. Buse, Chantal Mathieu, Jeremy H. Pettus, Charles M. Alexander, Tadej Battelino, F. Javier Ampudia-Blasco, Bruce W. Bode, Bertrand Cariou, Kelly L. Close, Paresh Dandona, Sanjoy Dutta, Ele Ferrannini, Spiros Fourlanos, George Grunberger, Simon R. Heller, Robert R. Henry, Martin J. Kurian, Jake A. Kushner, Tal Oron, Christopher G. Parkin, Thomas R. Pieber, Helena W. Rodbard, Desmond Schatz, Jay S. Skyler, William V. Tamborlane, Koutaro Yokote, Moshe Phillip
Journal: Diabetes Care
Diabetes Care 2019;42(6):1147–1154
https://doi.org/10.2337/dc18-2316
Published: 06 February 2019
View article titled, International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium–Glucose Cotransporter (SGLT) Inhibitors
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Includes: Supplementary data
Journal Articles

Empagliflozin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy: A Subanalysis of the EMPA-REG OUTCOME Trial

Subodh Verma, C. David Mazer, Deepak L. Bhatt, Satish R. Raj, Andrew T. Yan, Atul Verma, Ele Ferrannini, Gudrun Simons, Jisoo Lee, Bernard Zinman, Jyothis T. George, David Fitchett
Journal: Diabetes Care
Diabetes Care 2019;42(3):e42–e44
https://doi.org/10.2337/dc18-1959
Published: 23 January 2019
View article titled, Empagliflozin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy: A Subanalysis of the EMPA-REG OUTCOME Trial
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Journal Articles

How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial

Silvio E. Inzucchi, Bernard Zinman, David Fitchett, Christoph Wanner, Ele Ferrannini, Martin Schumacher, Claudia Schmoor, Kristin Ohneberg, Odd Erik Johansen, Jyothis T. George, Stefan Hantel, Erich Bluhmki, John M. Lachin
Journal: Diabetes Care
Diabetes Care 2018;41(2):356–363
https://doi.org/10.2337/dc17-1096
Published: 04 December 2017
View article titled, How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial
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Includes: Supplementary data
Journal Articles

Diabetes Research and Care Through the Ages

Bernard Zinman, Jay S. Skyler, Matthew C. Riddle, Ele Ferrannini
Journal: Diabetes Care
Diabetes Care 2017;40(10):1302–1313
https://doi.org/10.2337/dci17-0042
Published: 12 September 2017
View article titled, Diabetes Research and Care Through the Ages
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Journal Articles

Renal Handling of Ketones in Response to Sodium–Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes

Ele Ferrannini, Simona Baldi, Silvia Frascerra, Brenno Astiarraga, Elisabetta Barsotti, Aldo Clerico, Elza Muscelli
Journal: Diabetes Care
Diabetes Care 2017;40(6):771–776
https://doi.org/10.2337/dc16-2724
Published: 21 March 2017
View article titled, Renal Handling of Ketones in Response to Sodium–Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Response to Comment on Cefalu et al. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum. Diabetes Care 2016;39:1186–1201

William T. Cefalu, John B. Buse, Jaakko Tuomilehto, G. Alexander Fleming, Ele Ferrannini, Hertzel C. Gerstein, Peter H. Bennett, Ambady Ramachandran, Itamar Raz, Julio Rosenstock, Steven E. Kahn
Journal: Diabetes Care
Diabetes Care 2017;40(2):e23–e24
https://doi.org/10.2337/dci16-0036
Published: 11 January 2017
View article titled, Response to Comment on Cefalu et al. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a <em>Diabetes Care</em> Editors’ Expert Forum. Diabetes Care 2016;39:1186–1201
Open the PDF for Response to Comment on Cefalu et al. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a <em>Diabetes Care</em> Editors’ Expert Forum. Diabetes Care 2016;39:1186–1201 in another window