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Hirotaka Watada
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Journal Articles

Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial

Hirotaka Watada, Akane Takami, Robert Spranger, Atsushi Amano, Yasuhiro Hashimoto, Elisabeth Niemoeller
Journal: Diabetes Care
Diabetes Care 2020;43(6):1249–1257
https://doi.org/10.2337/dc19-2452
Published: 15 April 2020
View article titled, Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial
Open the PDF for Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial in another window
Journal Articles

Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial

Eiichi Araki, Shizuya Yamashita, Hidenori Arai, Koutaro Yokote, Jo Satoh, Toyoshi Inoguchi, Jiro Nakamura, Hiroshi Maegawa, Narihito Yoshioka, Yukio Tanizawa, Hirotaka Watada, Hideki Suganami, Shun Ishibashi
Journal: Diabetes Care
Diabetes Care 2018;41(3):538–546
https://doi.org/10.2337/dc17-1589
Published: 03 January 2018
View article titled, Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial
Open the PDF for Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial in another window
Includes: Supplementary data
Journal Articles

Erratum. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). A Randomized Controlled Trial. Diabetes Care 2016;39: 455–464

Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Tomio Onuma, Nobuichi Kuribayashi, Takeshi Osonoi, Hideaki Kaneto, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Kazunari Matsumoto, Hiroki Yokoyama, Mamiko Tsugawa, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada, on behalf of the Collaborators on the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE) Trial
Journal: Diabetes Care
Diabetes Care 2017;40(6):808
https://doi.org/10.2337/dc17-er06a
Published: 18 April 2017
View article titled, Erratum. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). A Randomized Controlled Trial. Diabetes Care 2016;39: 455–464
Open the PDF for Erratum. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). A Randomized Controlled Trial. Diabetes Care 2016;39: 455–464 in another window
Journal Articles

Erratum. Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 2016;39: 139–148

Tomoya Mita, Naoto Katakami, Hidenori Yoshii, Tomio Onuma, Hideaki Kaneto, Takeshi Osonoi, Toshihiko Shiraiwa, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Hiroki Yokoyama, Nobuichi Kuribayashi, Hideaki Jinnouchi, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada, on behalf of the Collaborators on the Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A) Trial
Journal: Diabetes Care
Diabetes Care 2017;40(6):808
https://doi.org/10.2337/dc17-er06b
Published: 18 April 2017
View article titled, Erratum. Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 2016;39: 139–148
Open the PDF for Erratum. Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A). Diabetes Care 2016;39: 139–148 in another window
Journal Articles

Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455–464

Tomoya Mita, Naoto Katakami, Iichiro Shimomura, Hirotaka Watada
Journal: Diabetes Care
Diabetes Care 2016;39(7):e104–e105
https://doi.org/10.2337/dci16-0012
Published: 09 June 2016
View article titled, Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455–464
Open the PDF for Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455–464 in another window
Journal Articles

Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial

Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Tomio Onuma, Nobuichi Kuribayashi, Takeshi Osonoi, Hideaki Kaneto, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Kazunari Matsumoto, Hiroki Yokoyama, Mamiko Tsugawa, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada, on behalf of the Collaborators on the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE) Trial
Journal: Diabetes Care
Diabetes Care 2016;39(3):455–464
https://doi.org/10.2337/dc15-2145
Published: 28 January 2016
View article titled, Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): <subtitle>A Randomized Controlled Trial</subtitle>
Open the PDF for Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): <subtitle>A Randomized Controlled Trial</subtitle> in another window
Includes: Supplementary data
Journal Articles

Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A)

Tomoya Mita, Naoto Katakami, Hidenori Yoshii, Tomio Onuma, Hideaki Kaneto, Takeshi Osonoi, Toshihiko Shiraiwa, Keisuke Kosugi, Yutaka Umayahara, Tsunehiko Yamamoto, Hiroki Yokoyama, Nobuichi Kuribayashi, Hideaki Jinnouchi, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Journal: Diabetes Care
Diabetes Care 2016;39(1):139–148
https://doi.org/10.2337/dc15-0781
Published: 01 December 2015
View article titled, Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A)
Open the PDF for Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A) in another window
Includes: Supplementary data
Journal Articles

Gut Dysbiosis and Detection of “Live Gut Bacteria” in Blood of Japanese Patients With Type 2 Diabetes

Junko Sato, Akio Kanazawa, Fuki Ikeda, Tomoaki Yoshihara, Hiromasa Goto, Hiroko Abe, Koji Komiya, Minako Kawaguchi, Tomoaki Shimizu, Takeshi Ogihara, Yoshifumi Tamura, Yuko Sakurai, Risako Yamamoto, Tomoya Mita, Yoshio Fujitani, Hiroshi Fukuda, Koji Nomoto, Takuya Takahashi, Takashi Asahara, Takahisa Hirose, Satoru Nagata, Yuichiro Yamashiro, Hirotaka Watada
Journal: Diabetes Care
Diabetes Care 2014;37(8):2343–2350
https://doi.org/10.2337/dc13-2817
Published: 12 July 2014
View article titled, Gut Dysbiosis and Detection of “Live Gut Bacteria” in Blood of Japanese Patients With Type 2 Diabetes
Open the PDF for Gut Dysbiosis and Detection of “Live Gut Bacteria” in Blood of Japanese Patients With Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

White Matter Alteration in Metabolic Syndrome: Diffusion tensor analysis

Keigo Shimoji, MD, Osamu Abe, MD, Takanori Uka, MD, Hasina Yasmin, MBBS, Koji Kamagata, MD, Kouichi Asahi, MD, Masaaki Hori, MD, Atsushi Nakanishi, MD, Yoshifumi Tamura, MD, Hirotaka Watada, MD, Ryuzo Kawamori, MD, Shigeki Aoki, MD
Journal: Diabetes Care
Diabetes Care 2013;36(3):696–700
https://doi.org/10.2337/dc12-0666
Published: 13 February 2013
View article titled, White Matter Alteration in Metabolic Syndrome: <subtitle>Diffusion tensor analysis</subtitle>
Open the PDF for White Matter Alteration in Metabolic Syndrome: <subtitle>Diffusion tensor analysis</subtitle> in another window
Includes: Supplementary data
Journal Articles

Combination of the Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes

Michiko Yoshida, MD, Tomoya Mita, MD, Risako Yamamoto, PHD, Tomoaki Shimizu, MD, Fuki Ikeda, MD, Chie Ohmura, MD, Akio Kanazawa, MD, Takahisa Hirose, MD, Ryuzo Kawamori, MD, Hirotaka Watada, MD
Journal: Diabetes Care
Diabetes Care 2012;35(1):178–180
https://doi.org/10.2337/dc11-1333
Published: 09 December 2011
View article titled, Combination of the Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes
Open the PDF for Combination of the Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes in another window
Journal Articles

Glucose Monitoring After Fruit Peeling: Pseudohyperglycemia When Neglecting Hand Washing Before Fingertip Blood Sampling: Wash your hands with tap water before you check blood glucose level

Takahisa Hirose, MD, Tomoya Mita, MD, Yoshio Fujitani, MD, Ryuzo Kawamori, MD, Hirotaka Watada, MD
Journal: Diabetes Care
Diabetes Care 2011;34(3):596–597
https://doi.org/10.2337/dc10-1705
Published: 17 February 2011
View article titled, Glucose Monitoring After Fruit Peeling: Pseudohyperglycemia When Neglecting Hand Washing Before Fingertip Blood Sampling: <subtitle>Wash your hands with tap water before you check blood glucose level</subtitle>
Open the PDF for Glucose Monitoring After Fruit Peeling: Pseudohyperglycemia When Neglecting Hand Washing Before Fingertip Blood Sampling: <subtitle>Wash your hands with tap water before you check blood glucose level</subtitle> in another window
Journal Articles

A Single Nucleotide Polymorphism in KCNQ1 Is Associated With Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes

Toshihiko Ohshige, MD, Yasushi Tanaka, MD, PHD, Shin-ichi Araki, MD, PHD, Tetsuya Babazono, MD, PHD, Masao Toyoda, MD, PHD, Tomoya Umezono, MD, PHD, Hirotaka Watada, MD, PHD, Daisuke Suzuki, MD, PHD, Yasuhiko Iwamoto, MD, PHD, Ryuzo Kawamori, MD, PHD, Yusuke Nakamura, MD, PHD, Shiro Maeda, MD, PHD
Journal: Diabetes Care
Diabetes Care 2010;33(4):842–846
https://doi.org/10.2337/dc09-1933
Published: 07 January 2010
View article titled, A Single Nucleotide Polymorphism in <em>KCNQ1</em> Is Associated With Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes
Open the PDF for A Single Nucleotide Polymorphism in <em>KCNQ1</em> Is Associated With Susceptibility to Diabetic Nephropathy in Japanese Subjects With Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Hypoglycemia Following a Nateglinide Overdose in a Suicide Attempt

Shiho Nakayama, MD, Takahisa Hirose, MD, Hirotaka Watada, MD, Yasushi Tanaka, MD, Ryuzo Kawamori, MD
Journal: Diabetes Care
Diabetes Care 2005;28(1):227–228
https://doi.org/10.2337/diacare.28.1.227
Published: 01 January 2005
View article titled, Hypoglycemia Following a Nateglinide Overdose in a Suicide Attempt
Open the PDF for Hypoglycemia Following a Nateglinide Overdose in a Suicide Attempt in another window
Journal Articles

RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects

Kunihiro Nakajima, MD, Yasushi Tanaka, MD, Takashi Nomiyama, MD, Takeshi Ogihara, MD, Fuki Ikeda, MD, Rei Kanno, MD, Noseki Iwashita, MD, Ken Sakai, MD, Hirotaka Watada, MD, Tomio Onuma, MD, Ryuzo Kawamori, MD
Journal: Diabetes Care
Diabetes Care 2003;26(3):892–898
https://doi.org/10.2337/diacare.26.3.892
Published: 01 March 2003
View article titled, RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects
Open the PDF for RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects in another window