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Jens J. Holst
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Journal Articles

Dasiglucagon Treatment for Postprandial Hypoglycemia After Gastric Bypass: A Randomized, Double-Blind, Placebo-Controlled Trial

Casper K. Nielsen, Caroline C. Øhrstrøm, Inas J.K. Houji, Mads M. Helsted, Liva S.L. Krogh, Nicklas J. Johansen, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Filip K. Knop
Journal: Diabetes Care
Diabetes Care 2023;46(12):2208–2217
https://doi.org/10.2337/dc23-1193
Published: 11 October 2023
View article titled, Dasiglucagon Treatment for Postprandial Hypoglycemia After Gastric Bypass: A Randomized, Double-Blind, Placebo-Controlled Trial
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Journal Articles

Empagliflozin Normalizes Fasting Hyperglycemia and Improves Postprandial Glucose Tolerance in Totally Pancreatectomized Patients: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Mille Baekdal, Sophie W. Nielsen, Carsten P. Hansen, Jan H. Storkholm, Gerrit van Hall, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Asger Lund, Filip K. Knop
Journal: Diabetes Care
Diabetes Care 2024;47(1):71–80
https://doi.org/10.2337/dc23-0645
Published: 13 September 2023
View article titled, Empagliflozin Normalizes Fasting Hyperglycemia and Improves Postprandial Glucose Tolerance in Totally Pancreatectomized Patients: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
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Journal Articles

Dasiglucagon Effectively Mitigates Postbariatric Postprandial Hypoglycemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

Casper K. Nielsen, Caroline C. Øhrstrøm, Urd L. Kielgast, Dorte L. Hansen, Bolette Hartmann, Jens J. Holst, Asger Lund, Tina Vilsbøll, Filip K. Knop
Journal: Diabetes Care
Diabetes Care 2022;45(6):1476–1481
https://doi.org/10.2337/dc21-2252
Published: 23 March 2022
View article titled, Dasiglucagon Effectively Mitigates Postbariatric Postprandial Hypoglycemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
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Journal Articles

Effects of DPP-4 Inhibitor Linagliptin Versus Sulfonylurea Glimepiride as Add-on to Metformin on Renal Physiology in Overweight Patients With Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial

Marcel H.A. Muskiet, Lennart Tonneijck, Mark M. Smits, Mark H.H. Kramer, D. Margriet Ouwens, Bolette Hartmann, Jens J. Holst, Daan J. Touw, A.H. Jan Danser, Jaap A. Joles, Daniël H. van Raalte
Journal: Diabetes Care
Diabetes Care 2020;43(11):2889–2893
https://doi.org/10.2337/dc20-0902
Published: 08 September 2020
View article titled, Effects of DPP-4 Inhibitor Linagliptin Versus Sulfonylurea Glimepiride as Add-on to Metformin on Renal Physiology in Overweight Patients With Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial
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Journal Articles

Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)

Alexander S. Christensen, Sofie Hædersdal, Julie Støy, Heidi Storgaard, Ulla Kampmann, Julie L. Forman, Marta Seghieri, Jens J. Holst, Torben Hansen, Filip K. Knop, Tina Vilsbøll
Journal: Diabetes Care
Diabetes Care 2020;43(9):2025–2033
https://doi.org/10.2337/dc20-0408
Published: 13 July 2020
View article titled, Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)
Open the PDF for Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA) in another window
Journal Articles

No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes

Natasha C. Bergmann, Lærke S. Gasbjerg, Sebastian M. Heimbürger, Liva S.L. Krogh, Flemming Dela, Bolette Hartmann, Jens J. Holst, Lene Jessen, Mikkel B. Christensen, Tina Vilsbøll, Asger Lund, Filip K. Knop
Journal: Diabetes Care
Diabetes Care 2020;43(3):588–596
https://doi.org/10.2337/dc19-0578
Published: 16 January 2020
View article titled, No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes
Open the PDF for No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People

Samyah Shadid, Kessewa Abosi-Appeadu, Anne-Sophie De Maertelaere, Justine Defreyne, Laurens Veldeman, Jens J. Holst, Bruno Lapauw, Tina Vilsbøll, Guy T’Sjoen
Journal: Diabetes Care
Diabetes Care 2020;43(2):411–417
https://doi.org/10.2337/dc19-1061
Published: 18 November 2019
View article titled, Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People
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Journal Articles

Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study

Preeshila Behary, George Tharakan, Kleopatra Alexiadou, Nicholas Johnson, Nicolai J. Wewer Albrechtsen, Julia Kenkre, Joyceline Cuenco, David Hope, Oluwaseun Anyiam, Sirazum Choudhury, Haya Alessimii, Ankur Poddar, James Minnion, Chedie Doyle, Gary Frost, Carel Le Roux, Sanjay Purkayastha, Krishna Moorthy, Waljit Dhillo, Jens J. Holst, Ahmed R. Ahmed, A. Toby Prevost, Stephen R. Bloom, Tricia M. Tan
Journal: Diabetes Care
Diabetes Care 2019;42(8):1446–1453
https://doi.org/10.2337/dc19-0449
Published: 08 June 2019
View article titled, Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study
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Includes: Supplementary data
Journal Articles

Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

Sine Knorr, Birgitte Bytoft, Zuzana Lohse, Anne B. Boisen, Tine D. Clausen, Rikke B. Jensen, Peter Damm, Henning Beck-Nielsen, Jens J. Holst, Bolette Hartmann, Holger J. Møller, Kurt Højlund, Claus H. Gravholt, Dorte M. Jensen
Journal: Diabetes Care
Diabetes Care 2019;42(8):1560–1568
https://doi.org/10.2337/dc19-0571
Published: 04 June 2019
View article titled, Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)
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Includes: Supplementary data
Journal Articles

Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers

Magnus F. Grøndahl, Jonatan I. Bagger, Asger Lund, Annesofie Faurschou, Jens F. Rehfeld, Jens J. Holst, Tina Vilsbøll, Filip K. Knop
Journal: Diabetes Care
Diabetes Care 2018;41(6):1260–1267
https://doi.org/10.2337/dc17-1818
Published: 30 March 2018
View article titled, Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers
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Includes: Supplementary data
Journal Articles

Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

Jennifer S. ten Kulve, Dick J. Veltman, Victor E.A. Gerdes, Liselotte van Bloemendaal, Frederik Barkhof, Carolyn F. Deacon, Jens J. Holst, Madeleine L. Drent, Michaela Diamant, Richard G. IJzerman
Journal: Diabetes Care
Diabetes Care 2017;40(11):1522–1529
https://doi.org/10.2337/dc16-2113
Published: 12 October 2017
View article titled, Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues
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Includes: Supplementary data
Journal Articles

Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals

Lena Mumme, Thomas G.K. Breuer, Stephan Rohrer, Nina Schenker, Björn A. Menge, Jens J. Holst, Michael A. Nauck, Juris J. Meier
Journal: Diabetes Care
Diabetes Care 2017;40(10):1314–1322
https://doi.org/10.2337/dc17-0792
Published: 27 July 2017
View article titled, Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals
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Includes: Supplementary data
Journal Articles

Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference

Signe Foghsgaard, Camilla Andreasen, Louise Vedtofte, Emilie S. Andersen, Emilie Bahne, Charlotte Strandberg, Thora Buhl, Jens J. Holst, Jens A. Svare, Tine D. Clausen, Elisabeth R. Mathiesen, Peter Damm, Lise L. Gluud, Filip K. Knop, Tina Vilsbøll
Journal: Diabetes Care
Diabetes Care 2017;40(1):109–116
https://doi.org/10.2337/dc16-1017
Published: 03 November 2016
View article titled, Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference
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Journal Articles

GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes

Thea A.S. Halden, Erlend J. Egeland, Anders Åsberg, Anders Hartmann, Karsten Midtvedt, Hassan Z. Khiabani, Jens J. Holst, Filip K. Knop, Mads Hornum, Bo Feldt-Rasmussen, Trond Jenssen
Journal: Diabetes Care
Diabetes Care 2016;39(4):617–624
https://doi.org/10.2337/dc15-2383
Published: 23 February 2016
View article titled, GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes
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Journal Articles

Twelve-Week Treatment With Liraglutide as Add-on to Insulin in Normal-Weight Patients With Poorly Controlled Type 1 Diabetes: A Randomized, Placebo-Controlled, Double-Blind Parallel Study

Christian S. Frandsen, Thomas F. Dejgaard, Jens J. Holst, Henrik U. Andersen, Birger Thorsteinsson, Sten Madsbad
Journal: Diabetes Care
Diabetes Care 2015;38(12):2250–2257
https://doi.org/10.2337/dc15-1037
Published: 20 October 2015
View article titled, Twelve-Week Treatment With Liraglutide as Add-on to Insulin in Normal-Weight Patients With Poorly Controlled Type 1 Diabetes: A Randomized, Placebo-Controlled, Double-Blind Parallel Study
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Includes: Supplementary data
Journal Articles

Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blind, Parallel-Group, Randomized Trial

Thomas Idorn, Filip K. Knop, Morten B. Jørgensen, Tonny Jensen, Marsela Resuli, Pernille M. Hansen, Karl B. Christensen, Jens J. Holst, Mads Hornum, Bo Feldt-Rasmussen
Journal: Diabetes Care
Diabetes Care 2016;39(2):206–213
https://doi.org/10.2337/dc15-1025
Published: 17 August 2015
View article titled, Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blind, Parallel-Group, Randomized Trial
Open the PDF for Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blind, Parallel-Group, Randomized Trial in another window
Includes: Supplementary data
Journal Articles

Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept

Marie-Christine Simon, Klaus Strassburger, Bettina Nowotny, Hubert Kolb, Peter Nowotny, Volker Burkart, Fariba Zivehe, Jong-Hee Hwang, Peter Stehle, Giovanni Pacini, Bolette Hartmann, Jens J. Holst, Colin MacKenzie, Laure B. Bindels, Ines Martinez, Jens Walter, Birgit Henrich, Nanette C. Schloot, Michael Roden
Journal: Diabetes Care
Diabetes Care 2015;38(10):1827–1834
https://doi.org/10.2337/dc14-2690
Published: 17 June 2015
View article titled, Intake of <em>Lactobacillus reuteri</em> Improves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept
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Includes: Supplementary data
Journal Articles

Glucose-Lowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: A Double-Blind, Randomized, Crossover Trial

Signe H. Østoft, Jonatan I. Bagger, Torben Hansen, Oluf Pedersen, Jens Faber, Jens J. Holst, Filip K. Knop, Tina Vilsbøll
Journal: Diabetes Care
Diabetes Care 2014;37(7):1797–1805
https://doi.org/10.2337/dc13-3007
Published: 12 June 2014
View article titled, Glucose-Lowering Effects and Low Risk of Hypoglycemia in Patients With Maturity-Onset Diabetes of the Young When Treated With a GLP-1 Receptor Agonist: A Double-Blind, Randomized, Crossover Trial
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Includes: Supplementary data
Journal Articles

GLP-1 Responses Are Heritable and Blunted in Acquired Obesity With High Liver Fat and Insulin Resistance

Niina Matikainen, Leonie H. Bogl, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Jaakko Kaprio, Aila Rissanen, Jens J. Holst, Kirsi H. Pietiläinen
Journal: Diabetes Care
Diabetes Care 2014;37(1):242–251
https://doi.org/10.2337/dc13-1283
Published: 11 December 2013
View article titled, GLP-1 Responses Are Heritable and Blunted in Acquired Obesity With High Liver Fat and Insulin Resistance
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Includes: Supplementary data
Journal Articles

Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes: Systematic review and meta-analysis of clinical studies

Salvatore Calanna, MD, Mikkel Christensen, MD, Jens J. Holst, MD, DMSC, Blandine Laferrère, MD, Lise L. Gluud, MD, DMSC, Tina Vilsbøll, MD, DMSC, Filip K. Knop, MD, PHD
Journal: Diabetes Care
Diabetes Care 2013;36(10):3346–3352
https://doi.org/10.2337/dc13-0465
Published: 14 September 2013
View article titled, Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes: <subtitle>Systematic review and meta-analysis of clinical studies</subtitle>
Open the PDF for Secretion of Glucose-Dependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes: <subtitle>Systematic review and meta-analysis of clinical studies</subtitle> in another window
Includes: Supplementary data