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Robert J. Heine
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Journal Articles

Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program

Philip Zeitler, Rodolfo J. Galindo, Melanie J. Davies, Brandon K. Bergman, Vivian T. Thieu, Claudia Nicolay, Sheryl Allen, Robert J. Heine, Clare J. Lee
Journal: Diabetes Care
Diabetes Care 2024;47(6):1056–1064
https://doi.org/10.2337/dc23-2356
Published: 19 April 2024
View article titled, Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program
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Journal Articles

Perspectives on Some Controversies in Cardiovascular Disease Risk Assessment in the Pharmaceutical Development of Glucose-Lowering Medications

Byron J. Hoogwerf, David H. Manner, Haoda Fu, Elena Moscarelli, Brenda L. Gaydos, Robert J. Heine
Journal: Diabetes Care
Diabetes Care 2016;39(Supplement_2):S219–S227
https://doi.org/10.2337/dcS15-3025
Published: 16 July 2016
View article titled, Perspectives on Some Controversies in Cardiovascular Disease Risk Assessment in the Pharmaceutical Development of Glucose-Lowering Medications
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Journal Articles

Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels

Mark M. Smits, Mathijs C. Bunck, Michaela Diamant, Anja Corner, Bjorn Eliasson, Robert J. Heine, Ulf Smith, Hannele Yki-Järvinen, Daniël H. van Raalte
Journal: Diabetes Care
Diabetes Care 2016;39(3):e42–e43
https://doi.org/10.2337/dc15-2489
Published: 30 December 2015
View article titled, Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels
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Journal Articles

Comment on Zhang et al. Second-Line Agents for Glycemic Control for Type 2 Diabetes: Are Newer Agents Better? Diabetes Care 2014;37:1338–1345

Jay Bae, Bradley H. Curtis, David M. Kendall, Robert J. Heine
Journal: Diabetes Care
Diabetes Care 2014;37(9):e204
https://doi.org/10.2337/dc14-1041
Published: 07 August 2014
View article titled, Comment on Zhang et al. Second-Line Agents for Glycemic Control for Type 2 Diabetes: Are Newer Agents Better? Diabetes Care 2014;37:1338–1345
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Journal Articles

Effects of Exenatide on Measures of β-Cell Function After 3 Years in Metformin-Treated Patients With Type 2 Diabetes

Mathijs C. Bunck, MD, Anja Cornér, MD, Bjorn Eliasson, MD, Robert J. Heine, MD, Rimma M. Shaginian, MD, Marja-Riitta Taskinen, MD, Ulf Smith, MD, Hannele Yki-Järvinen, MD, Michaela Diamant, MD
Journal: Diabetes Care
Diabetes Care 2011;34(9):2041–2047
https://doi.org/10.2337/dc11-0291
Published: 19 August 2011
View article titled, Effects of Exenatide on Measures of β-Cell Function After 3 Years in Metformin-Treated Patients With Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Does Glucose Variability Influence the Relationship Between Mean Plasma Glucose and HbA1c Levels in Type 1 and Type 2 Diabetic Patients?

Judith C. Kuenen, MD, Rikke Borg, MD, Dirk J. Kuik, MSC, Hui Zheng, PHD, David Schoenfeld, PHD, Michaela Diamant, MD, David M. Nathan, MD, Robert J. Heine, MD, on behalf of the ADAG Study Group
Journal: Diabetes Care
Diabetes Care 2011;34(8):1843–1847
https://doi.org/10.2337/dc10-2217
Published: 16 July 2011
View article titled, Does Glucose Variability Influence the Relationship Between Mean Plasma Glucose and HbA<sub>1c</sub> Levels in Type 1 and Type 2 Diabetic Patients?
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Includes: Supplementary data
Journal Articles

Exenatide Affects Circulating Cardiovascular Risk Biomarkers Independently of Changes in Body Composition

Mathijs C. Bunck, MD, Michaela Diamant, MD, PHD, Bjorn Eliasson, MD, PHD, Anja Cornér, MD, Rimma M. Shaginian, MD, Robert J. Heine, MD, PHD, FRCP, Marja-Riitta Taskinen, MD, PHD, Hannele Yki-Järvinen, MD, PHD, FRCP, Ulf Smith, MD, PHD, FRCP
Journal: Diabetes Care
Diabetes Care 2010;33(8):1734–1737
https://doi.org/10.2337/dc09-2361
Published: 27 April 2010
View article titled, Exenatide Affects Circulating Cardiovascular Risk Biomarkers Independently of Changes in Body Composition
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Includes: Supplementary data
Journal Articles

Microalbuminuria and Cardiovascular Autonomic Dysfunction Are Independently Associated With Cardiovascular Mortality: Evidence for Distinct Pathways: The Hoorn Study

Hanneke J.B.H. Beijers, MD, Isabel Ferreira, PHD, Bert Bravenboer, MD, PHD, Jacqueline M. Dekker, PHD, Giel Nijpels, MD, PHD, Robert J. Heine, MD, PHD, Coen D.A. Stehouwer, MD, PHD
Journal: Diabetes Care
Diabetes Care 2009;32(9):1698–1703
https://doi.org/10.2337/dc08-1544
Published: 29 June 2009
View article titled, Microalbuminuria and Cardiovascular Autonomic Dysfunction Are Independently Associated With Cardiovascular Mortality: Evidence for Distinct Pathways: <subtitle>The Hoorn Study</subtitle>
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Includes: Supplementary data
Journal Articles

One-Year Treatment With Exenatide Improves β-Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients: A randomized, controlled trial

Mathijs C. Bunck, MD, Michaela Diamant, MD, PHD, Anja Cornér, MD, Bjorn Eliasson, MD, PHD, Jaret L. Malloy, PHD, Rimma M. Shaginian, MD, Wei Deng, PHD, David M. Kendall, MD, Marja-Riitta Taskinen, MD, PHD, Ulf Smith, MD, PHD, FRCP, Hannele Yki-Järvinen, MD, PHD, FRCP, Robert J. Heine, MD, PHD, FRCP
Journal: Diabetes Care
Diabetes Care 2009;32(5):762–768
https://doi.org/10.2337/dc08-1797
Published: 05 February 2009
View article titled, One-Year Treatment With Exenatide Improves β-Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients: <subtitle>A randomized, controlled trial</subtitle>
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Includes: Supplementary data
Journal Articles

Hyperglycemia and Stroke Mortality: Comparison between fasting and 2-h glucose criteria

Marjukka Hyvärinen, MSC, Qing Qiao, MD, PHD, Jaakko Tuomilehto, MD, PHD, Tiina Laatikainen, MD, PHD, Robert J. Heine, MD, PHD, Coen D.A. Stehouwer, MD, PHD, K. George M.M. Alberti, MD, PHD, Kalevi Pyörälä, MD, PHD, Björn Zethelius, MD, PHD, Birgitta Stegmayr, MD, PHD, for the DECODE Study Group
Journal: Diabetes Care
Diabetes Care 2009;32(2):348–354
https://doi.org/10.2337/dc08-1411
Published: 01 February 2009
View article titled, Hyperglycemia and Stroke Mortality: <subtitle>Comparison between fasting and 2-h glucose criteria</subtitle>
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Includes: Supplementary data
Journal Articles

Diabetes-Related Symptom Distress in Association With Glucose Metabolism and Comorbidity: The Hoorn Study

Marcel C. Adriaanse, PHD, Frans Pouwer, PHD, Jacqueline M. Dekker, PHD, Giel Nijpels, MD, PHD, Coen D. Stehouwer, MD, PHD, Robert J. Heine, MD, PHD, Frank J. Snoek, PHD
Journal: Diabetes Care
Diabetes Care 2008;31(12):2268–2270
https://doi.org/10.2337/dc08-1074
Published: 01 December 2008
View article titled, Diabetes-Related Symptom Distress in Association With Glucose Metabolism and Comorbidity: <subtitle>The Hoorn Study</subtitle>
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Includes: Supplementary data
Journal Articles

Translating the A1C Assay Into Estimated Average Glucose Values

David M. Nathan, MD, Judith Kuenen, MD, Rikke Borg, MD, Hui Zheng, PHD, David Schoenfeld, PHD, Robert J. Heine, MD, for the A1c-Derived Average Glucose (ADAG) Study Group
Journal: Diabetes Care
Diabetes Care 2008;31(8):1473–1478
https://doi.org/10.2337/dc08-0545
Published: 01 August 2008
View article titled, Translating the A1C Assay Into Estimated Average Glucose Values
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Includes: Supplementary data
Journal Articles

Pancreatic Fat Content and β-Cell Function in Men With and Without Type 2 Diabetes

Maarten E. Tushuizen, MD, Mathijs C. Bunck, MD, Petra J. Pouwels, PHD, Saskia Bontemps, MSC, Jan Hein T. van Waesberghe, MD, PHD, Roger K. Schindhelm, MD, PHD, Andrea Mari, PHD, Robert J. Heine, MD, PHD, FRCP, Michaela Diamant, MD, PHD
Journal: Diabetes Care
Diabetes Care 2007;30(11):2916–2921
https://doi.org/10.2337/dc07-0326
Published: 01 November 2007
View article titled, Pancreatic Fat Content and β-Cell Function in Men With and Without Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients: Response to Targher et al.

Roger K. Schindhelm, MD, PHD, MEPI, Robert J. Heine, MD, PHD, FRCP, Michaela Diamant, MD, PHD
Journal: Diabetes Care
Diabetes Care 2007;30(9):e94
https://doi.org/10.2337/dc07-0982
Published: 01 September 2007
View article titled, Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients: <subtitle>Response to Targher et al.</subtitle>
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Journal Articles

Fasting and Postprandial Glycoxidative and Lipoxidative Stress Are Increased in Women With Type 2 Diabetes

Roger K. Schindhelm, BSC, MD, Marjan Alssema, MSC, Peter G. Scheffer, PHD, Michaela Diamant, MD, PHD, Jacqueline M. Dekker, PHD, Rob Barto, Giel Nijpels, MD, PHD, Piet J. Kostense, PHD, Robert J. Heine, MD, PHD, Casper G. Schalkwijk, PHD, Tom Teerlink, PHD
Journal: Diabetes Care
Diabetes Care 2007;30(7):1789–1794
https://doi.org/10.2337/dc06-2585
Published: 01 July 2007
View article titled, Fasting and Postprandial Glycoxidative and Lipoxidative Stress Are Increased in Women With Type 2 Diabetes
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Journal Articles

Elevated Endothelial Microparticles Following Consecutive Meals Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Maarten E. Tushuizen, MD, Rienk Nieuwland, PHD, Cees Rustemeijer, MD, PHD, Bert E. Hensgens, PHD, Augueste Sturk, PHD, Robert J. Heine, MD, PHD, FRCP, Michaela Diamant, MD, PHD
Journal: Diabetes Care
Diabetes Care 2007;30(3):728–730
https://doi.org/10.2337/dc06-1473
Published: 01 March 2007
View article titled, Elevated Endothelial Microparticles Following Consecutive Meals Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes
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Journal Articles

Impaired Fasting Glucose and Impaired Glucose Tolerance: Implications for care

David M. Nathan, MD, Mayer B. Davidson, MD, Ralph A. DeFronzo, MD, Robert J. Heine, MD, PHD, FRCP, Robert R. Henry, MD, Richard Pratley, MD, Bernard Zinman, MD
Journal: Diabetes Care
Diabetes Care 2007;30(3):753–759
https://doi.org/10.2337/dc07-9920
Published: 01 March 2007
View article titled, Impaired Fasting Glucose and Impaired Glucose Tolerance: <subtitle>Implications for care</subtitle>
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Journal Articles

High Risk of Cardiovascular Mortality in Individuals With Impaired Fasting Glucose Is Explained by Conversion to Diabetes: The Hoorn Study

Josina M. Rijkelijkhuizen, PHD, Giel Nijpels, MD, PHD, Robert J. Heine, MD, PHD, Lex M. Bouter, PHD, Coen D.A. Stehouwer, MD, PHD, Jacqueline M. Dekker, PHD
Journal: Diabetes Care
Diabetes Care 2007;30(2):332–336
https://doi.org/10.2337/dc06-1238
Published: 01 February 2007
View article titled, High Risk of Cardiovascular Mortality in Individuals With Impaired Fasting Glucose Is Explained by Conversion to Diabetes: <subtitle>The Hoorn Study</subtitle>
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Journal Articles

Associations of Adiponectin Levels With Incident Impaired Glucose Metabolism and Type 2 Diabetes in Older Men and Women : The Hoorn Study

Marieke B. Snijder, PHD, Robert J. Heine, MD, PHD, Jacob C. Seidell, PHD, Lex M. Bouter, PHD, Coen D.A. Stehouwer, MD, PHD, Giel Nijpels, MD, PHD, Tohru Funahashi, PHD, Yuji Matsuzawa, MD, PHD, Iichiro Shimomura, MD, PHD, Jacqueline M. Dekker, PHD
Journal: Diabetes Care
Diabetes Care 2006;29(11):2498–2503
https://doi.org/10.2337/dc06-0952
Published: 01 November 2006
View article titled, Associations of Adiponectin Levels With Incident Impaired Glucose Metabolism and Type 2 Diabetes in Older Men and Women : <subtitle>The Hoorn Study</subtitle>
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Journal Articles

Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

David M. Nathan, MD, John B. Buse, MD, PHD, Mayer B. Davidson, MD, Robert J. Heine, MD, Rury R. Holman, FRCP, Robert Sherwin, MD, Bernard Zinman, MD
Journal: Diabetes Care
Diabetes Care 2006;29(8):1963–1972
https://doi.org/10.2337/dc06-9912
Published: 01 August 2006
View article titled, Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: <subtitle>A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes</subtitle>
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