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Rury R. Holman
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Journal Articles

Osteoprotegerin, Osteopontin, and Osteocalcin Are Associated With Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL

Ernesto Maddaloni, Maggie Nguyen, Svati H. Shah, Rury R. Holman
Journal: Diabetes Care
Diabetes Care dc241455
https://doi.org/10.2337/dc24-1455
Published: 22 November 2024
View article titled, Osteoprotegerin, Osteopontin, and Osteocalcin Are Associated With Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL
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Journal Articles

Effect of Fenofibrate Therapy on Laser Treatment for Diabetic Retinopathy: A Meta-Analysis of Randomized Controlled Trials

David Preiss, Enti Spata, Rury R. Holman, Ruth L. Coleman, Laura Lovato, Henry N. Ginsberg, Jane Armitage
Journal: Diabetes Care
Diabetes Care 2022;45(1):e1–e2
https://doi.org/10.2337/dc21-1439
Published: 28 December 2021
View article titled, Effect of Fenofibrate Therapy on Laser Treatment for Diabetic Retinopathy: A Meta-Analysis of Randomized Controlled Trials
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Journal Articles

Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine

Abhinav Sharma, Yinggan Zheng, Justin A. Ezekowitz, Cynthia M. Westerhout, Jacob A. Udell, Shaun G. Goodman, Paul W. Armstrong, John B. Buse, Jennifer B. Green, Robert G. Josse, Keith D. Kaufman, Darren K. McGuire, Giuseppe Ambrosio, Lee-Ming Chuang, Renato D. Lopes, Eric D. Peterson, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2022;45(1):204–212
https://doi.org/10.2337/dc20-2806
Published: 29 October 2021
View article titled, Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine
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Journal Articles

Increased Risk of Incident Heart Failure and Death Is Associated With Insulin Resistance in People With Newly Diagnosed Type 2 Diabetes: UKPDS 89

Malgorzata Wamil, Ruth L. Coleman, Amanda I. Adler, John J.V. McMurray, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2021;44(8):1877–1884
https://doi.org/10.2337/dc21-0429
Published: 11 August 2021
View article titled, Increased Risk of Incident Heart Failure and Death Is Associated With Insulin Resistance in People With Newly Diagnosed Type 2 Diabetes: UKPDS 89
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Journal Articles

Historical HbA1c Values May Explain the Type 2 Diabetes Legacy Effect: UKPDS 88

Marcus Lind, Henrik Imberg, Ruth L. Coleman, Olle Nerman, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2021;44(10):2231–2237
https://doi.org/10.2337/dc20-2439
Published: 08 July 2021
View article titled, Historical HbA<sub>1c</sub> Values May Explain the Type 2 Diabetes Legacy Effect: UKPDS 88
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Journal Articles

Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL

Eberhard Standl, Susanna R. Stevens, Yuliya Lokhnygina, M. Angelyn Bethel, John B. Buse, Stephanie M. Gustavson, Aldo P. Maggioni, Robert J. Mentz, Adrian F. Hernandez, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2020;43(3):643–652
https://doi.org/10.2337/dc19-1079
Published: 27 December 2020
View article titled, Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL
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Includes: Supplementary data
Journal Articles

Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study

Louise A. Donnelly, John M. Dennis, Ruth L. Coleman, Naveed Sattar, Andrew T. Hattersley, Rury R. Holman, Ewan R. Pearson
Journal: Diabetes Care
Diabetes Care 2020;43(10):2493–2499
https://doi.org/10.2337/dc20-1104
Published: 14 August 2020
View article titled, Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study
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Journal Articles

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data

Jose Leal, Shelby D. Reed, Rishi Patel, Oliver Rivero-Arias, Yanhong Li, Kevin A. Schulman, Robert M. Califf, Rury R. Holman, Alastair M. Gray
Journal: Diabetes Care
Diabetes Care 2020;43(10):2485–2492
https://doi.org/10.2337/dc20-0717
Published: 12 August 2020
View article titled, Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data
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Journal Articles

Impact of Acarbose on Incident Diabetes and Regression to Normoglycemia in People With Coronary Heart Disease and Impaired Glucose Tolerance: Insights From the ACE Trial

Hertzel C. Gerstein, Ruth L. Coleman, Charles A.B. Scott, Shishi Xu, Jaakko Tuomilehto, Lars Rydén, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2020;43(9):2242–2247
https://doi.org/10.2337/dc19-2046
Published: 08 July 2020
View article titled, Impact of Acarbose on Incident Diabetes and Regression to Normoglycemia in People With Coronary Heart Disease and Impaired Glucose Tolerance: Insights From the ACE Trial
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Journal Articles

Within-Trial Evaluation of Medical Resources, Costs, and Quality of Life Among Patients With Type 2 Diabetes Participating in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)

Shelby D. Reed, Yanhong Li, Helen A. Dakin, Frauke Becker, Jose Leal, Stephanie M. Gustavson, Bernt Kartman, Eric Wittbrodt, Robert J. Mentz, Neha J. Pagidipati, M. Angelyn Bethel, Alastair M. Gray, Rury R. Holman, Adrian F. Hernandez
Journal: Diabetes Care
Diabetes Care 2020;43(2):374–381
https://doi.org/10.2337/dc19-0950
Published: 05 December 2019
View article titled, Within-Trial Evaluation of Medical Resources, Costs, and Quality of Life Among Patients With Type 2 Diabetes Participating in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)
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Includes: Supplementary data
Journal Articles

Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial

M. Angelyn Bethel, Robert J. Mentz, Peter Merrill, John B. Buse, Juliana C. Chan, Shaun G. Goodman, Nayyar Iqbal, Neli Jakuboniene, Brian Katona, Yuliya Lokhnygina, Renato D. Lopes, Aldo P. Maggioni, Peter Ohman, Tsvetalina Tankova, George L. Bakris, Adrian F. Hernandez, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2020;43(2):446–452
https://doi.org/10.2337/dc19-1065
Published: 22 November 2019
View article titled, Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial
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Includes: Supplementary data
Journal Articles

Comment on Kim et al. The Effect of a Smartphone-Based, Patient-Centered Diabetes Care System in Patients With Type 2 Diabetes: A Randomized, Controlled Trial for 24 Weeks. Diabetes Care 2019;42:3–9

Xiqian Huo, Rury R. Holman, Jane Armitage
Journal: Diabetes Care
Diabetes Care 2019;42(7):e125
https://doi.org/10.2337/dc19-0535
Published: 12 June 2019
View article titled, Comment on Kim et al. The Effect of a Smartphone-Based, Patient-Centered Diabetes Care System in Patients With Type 2 Diabetes: A Randomized, Controlled Trial for 24 Weeks. Diabetes Care 2019;42:3–9
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Journal Articles

Comment on Davis et al. Effects of Severe Hypoglycemia on Cardiovascular Outcomes and Death in the Veterans Affairs Diabetes Trial. Diabetes Care 2019;42:157–163

Eberhard Standl, Jennifer B. Green, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2019;42(6):e95
https://doi.org/10.2337/dc18-2597
Published: 10 May 2019
View article titled, Comment on Davis et al. Effects of Severe Hypoglycemia on Cardiovascular Outcomes and Death in the Veterans Affairs Diabetes Trial. Diabetes Care 2019;42:157–163
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Journal Articles

Diabetes Care Editors’ Expert Forum 2018: Managing Big Data for Diabetes Research and Care

Matthew C. Riddle, Lawrence Blonde, Hertzel C. Gerstein, Edward W. Gregg, Rury R. Holman, John M. Lachin, Gregory A. Nichols, Alexander Turchin, William T. Cefalu
Journal: Diabetes Care
Diabetes Care 2019;42(6):1136–1146
https://doi.org/10.2337/dci19-0020
Published: 10 May 2019
View article titled, <em>Diabetes Care</em> Editors’ Expert Forum 2018: Managing Big Data for Diabetes Research and Care
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Journal Articles

Changes in Serum Calcitonin Concentrations, Incidence of Medullary Thyroid Carcinoma, and Impact of Routine Calcitonin Concentration Monitoring in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL)

M. Angelyn Bethel, Rishi A. Patel, Vivian P. Thompson, Peter Merrill, Shelby D. Reed, Yanhong Li, Sara Ahmadi, Brian G. Katona, Stephanie M. Gustavson, Peter Ohman, Nayyar Iqbal, Robert F. Gagel, Adrian F. Hernandez, John B. Buse, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2019;42(6):1075–1080
https://doi.org/10.2337/dc18-2028
Published: 22 April 2019
View article titled, Changes in Serum Calcitonin Concentrations, Incidence of Medullary Thyroid Carcinoma, and Impact of Routine Calcitonin Concentration Monitoring in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL)
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Includes: Supplementary data
Journal Articles

Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL

Lindsay E. Clegg, Hiddo J.L. Heerspink, Robert C. Penland, Weifeng Tang, David W. Boulton, Srinivas Bachina, Robert D. Fox, Peter Fenici, Marcus Thuresson, Robert J. Mentz, Adrian F. Hernandez, Rury R. Holman
Journal: Diabetes Care
Diabetes Care 2019;42(2):318–326
https://doi.org/10.2337/dc18-1871
Published: 06 December 2018
View article titled, Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL
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Includes: Supplementary data
Journal Articles

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data

John M. Dennis, William E. Henley, Michael N. Weedon, Mike Lonergan, Lauren R. Rodgers, Angus G. Jones, William T. Hamilton, Naveed Sattar, Salim Janmohamed, Rury R. Holman, Ewan R. Pearson, Beverley M. Shields, Andrew T. Hattersley, MASTERMIND Consortium, Catherine Angwin, Kennedy J. Cruickshank, Andrew J. Farmer, Stephen C.L. Gough, Alastair M. Gray, Christopher Hyde, Christopher Jennison, Mark Walker
Journal: Diabetes Care
Diabetes Care 2018;41(9):1844–1853
https://doi.org/10.2337/dc18-0344
Published: 02 August 2018
View article titled, Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data
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Includes: Supplementary data
Journal Articles

A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks

Matthew C. Riddle, Hertzel C. Gerstein, Rury R. Holman, Silvio E. Inzucchi, Bernard Zinman, Sophia Zoungas, William T. Cefalu
Journal: Diabetes Care
Diabetes Care 2018;41(6):1121–1124
https://doi.org/10.2337/dci18-0018
Published: 11 May 2018
View article titled, A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks
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Journal Articles

Aspects of Multicomponent Integrated Care Promote Sustained Improvement in Surrogate Clinical Outcomes: A Systematic Review and Meta-analysis

Lee Ling Lim, Eric S.H. Lau, Alice P.S. Kong, Melanie J. Davies, Naomi S. Levitt, Björn Eliasson, Carlos A. Aguilar-Salinas, Guang Ning, Yutaka Seino, Wing Yee So, Margaret McGill, Graham D. Ogle, Trevor J. Orchard, Philip Clarke, Rury R. Holman, Edward W. Gregg, Juan José Gagliardino, Juliana C.N. Chan
Journal: Diabetes Care
Diabetes Care 2018;41(6):1312–1320
https://doi.org/10.2337/dc17-2010
Published: 11 May 2018
View article titled, Aspects of Multicomponent Integrated Care Promote Sustained Improvement in Surrogate Clinical Outcomes: A Systematic Review and Meta-analysis
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Includes: Supplementary data
Journal Articles

Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy

John M. Dennis, Beverley M. Shields, Anita V. Hill, Bridget A. Knight, Timothy J. McDonald, Lauren R. Rodgers, Michael N. Weedon, William E. Henley, Naveed Sattar, Rury R. Holman, Ewan R. Pearson, Andrew T. Hattersley, Angus G. Jones
Journal: Diabetes Care
Diabetes Care 2018;41(4):705–712
https://doi.org/10.2337/dc17-1827
Published: 31 January 2018
View article titled, Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy
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Includes: Supplementary data