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Journal Articles

Metformin and Cancer: Solutions to a Real-World Evidence Failure

Oriana Hoi Yun Yu, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2023;46(5):904–912
https://doi.org/10.2337/dci22-0047
Published: 26 April 2023
View article titled, Metformin and Cancer: Solutions to a Real-World Evidence Failure
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Journal Articles

Sodium–Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study

Oriana Hoi Yun Yu, Sophie Dell’Aniello, Baiju R. Shah, Vanessa C. Brunetti, Jean-Marc Daigle, Michael Fralick, Antonios Douros, Nianping Hu, Silvia Alessi-Severini, Anat Fisher, Shawn C. Bugden, Paul E. Ronksley, Kristian B. Filion, Pierre Ernst, Lisa M. Lix, Canadian Network for Observational Drug Effect Studies (CNODES) Investigators, Samy Suissa, Colin R. Dormuth, Brenda R. Hemmelgarn, Jacqueline Quail, Dan Chateau, J. Michael Paterson, Jacques LeLorier, Adrian R. Levy, Pierre Ernst, Kristian B. Filion, Lisa M. Lix, Robert W. Platt, Ingrid S. Sketris
Journal: Diabetes Care
Diabetes Care 2020;43(10):2444–2452
https://doi.org/10.2337/dc20-0267
Published: 05 August 2020
View article titled, Sodium–Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study
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Journal Articles

Response to Comment on Suissa. Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias? Diabetes Care 2018;41:6–10

Samy Suissa
Journal: Diabetes Care
Diabetes Care 2018;41(6):e109–e110
https://doi.org/10.2337/dci18-0015
Published: 11 May 2018
View article titled, Response to Comment on Suissa. Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias? Diabetes Care 2018;41:6–10
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Journal Articles

Mortality Reduction in EMPA-REG OUTCOME Trial: Beyond the Antidiabetes Effect

Samy Suissa
Journal: Diabetes Care
Diabetes Care 2018;41(2):219–223
https://doi.org/10.2337/dc17-1059
Published: 12 January 2018
View article titled, Mortality Reduction in EMPA-REG OUTCOME Trial: Beyond the Antidiabetes Effect
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Includes: Supplementary data
Journal Articles

Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias?

Samy Suissa
Journal: Diabetes Care
Diabetes Care 2018;41(1):6–10
https://doi.org/10.2337/dc17-1223
Published: 11 December 2017
View article titled, Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias?
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Journal Articles

Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events

Antonios Douros, Hui Yin, Oriana Hoi Yun Yu, Kristian B. Filion, Laurent Azoulay, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2017;40(11):1506–1513
https://doi.org/10.2337/dc17-0595
Published: 01 September 2017
View article titled, Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events
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Includes: Supplementary data
Journal Articles

Sulfonylureas and the Risks of Cardiovascular Events and Death: A Methodological Meta-Regression Analysis of the Observational Studies

Laurent Azoulay, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2017;40(5):706–714
https://doi.org/10.2337/dc16-1943
Published: 12 April 2017
View article titled, Sulfonylureas and the Risks of Cardiovascular Events and Death: A Methodological Meta-Regression Analysis of the Observational Studies
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Journal Articles

Identifying Causes for Excess Mortality in Patients With Diabetes: Closer but Not There Yet

Oriana Hoi Yun Yu, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2016;39(11):1851–1853
https://doi.org/10.2337/dci16-0026
Published: 11 October 2016
View article titled, Identifying Causes for Excess Mortality in Patients With Diabetes: Closer but Not There Yet
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Journal Articles

DPP-4 Inhibitors and Heart Failure: Some Reassurance, Some Uncertainty

Kristian B. Filion, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2016;39(5):735–737
https://doi.org/10.2337/dci15-0036
Published: 14 April 2016
View article titled, DPP-4 Inhibitors and Heart Failure: Some Reassurance, Some Uncertainty
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Journal Articles

Effect of Long-Acting Insulin Analogs on the Risk of Cancer: A Systematic Review of Observational Studies

Jennifer W. Wu, Kristian B. Filion, Laurent Azoulay, Margaret K. Doll, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2016;39(3):486–494
https://doi.org/10.2337/dc15-1816
Published: 06 January 2016
View article titled, Effect of Long-Acting Insulin Analogs on the Risk of Cancer: A Systematic Review of Observational Studies
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Includes: Supplementary data
Journal Articles

Comment on Bordeleau et al. The Association of Basal Insulin Glargine and/or n-3 Fatty Acids With Incident Cancers in Patients With Dysglycemia. Diabetes Care 2014;37:1360–1366

Samy Suissa, Laurent Azoulay
Journal: Diabetes Care
Diabetes Care 2014;37(10):e216
https://doi.org/10.2337/dc14-1075
Published: 10 September 2014
View article titled, Comment on Bordeleau et al. The Association of Basal Insulin Glargine and/or n-3 Fatty Acids With Incident Cancers in Patients With Dysglycemia. Diabetes Care 2014;37:1360–1366
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Journal Articles

Incretin-Based Drugs and the Risk of Congestive Heart Failure

Oriana Hoi Yun Yu, Kristian B. Filion, Laurent Azoulay, Valerie Patenaude, Agnieszka Majdan, Samy Suissa
Journal: Diabetes Care
Diabetes Care 2015;38(2):277–284
https://doi.org/10.2337/dc14-1459
Published: 09 September 2014
View article titled, Incretin-Based Drugs and the Risk of Congestive Heart Failure
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Includes: Supplementary data
Journal Articles

Metformin and Cancer: Mounting Evidence Against an Association

Samy Suissa, Laurent Azoulay
Journal: Diabetes Care
Diabetes Care 2014;37(7):1786–1788
https://doi.org/10.2337/dc14-0500
Published: 12 June 2014
View article titled, Metformin and Cancer: Mounting Evidence Against an Association
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Journal Articles

Response to Bodmer et al. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673

Samy Suissa, PHD, Laurent Azoulay, PHD
Journal: Diabetes Care
Diabetes Care 2013;36(6):e86
https://doi.org/10.2337/dc13-0257
Published: 15 May 2013
View article titled, Response to Bodmer et al. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673
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Journal Articles

Response to Yang and Chan. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673

Samy Suissa, PHD, Laurent Azoulay, PHD
Journal: Diabetes Care
Diabetes Care 2013;36(6):e88
https://doi.org/10.2337/dc13-0133
Published: 15 May 2013
View article titled, Response to Yang and Chan. Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies. Diabetes Care 2012;35:2665–2673
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Journal Articles

Response to Comment on: Smiechowski et al. The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes. Diabetes Care 2013;36:124–129

Samy Suissa, PHD, Laurent Azoulay, PHD
Journal: Diabetes Care
Diabetes Care 2013;36(3):e41
https://doi.org/10.2337/dc12-2262
Published: 13 February 2013
View article titled, Response to Comment on: Smiechowski et al. The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes. Diabetes Care 2013;36:124–129
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Journal Articles

The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes

Brielan B. Smiechowski, MSC, Laurent Azoulay, PHD, Hui Yin, MSC, Michael N. Pollak, MD, Samy Suissa, PHD
Journal: Diabetes Care
Diabetes Care 2013;36(1):124–129
https://doi.org/10.2337/dc12-0740
Published: 11 December 2012
View article titled, The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes
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Journal Articles

Metformin and the Risk of Cancer: Time-related biases in observational studies

Samy Suissa, PHD, Laurent Azoulay, PHD
Journal: Diabetes Care
Diabetes Care 2012;35(12):2665–2673
https://doi.org/10.2337/dc12-0788
Published: 14 November 2012
View article titled, Metformin and the Risk of Cancer: <subtitle>Time-related biases in observational studies</subtitle>
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Journal Articles

Factors Predicting Course of β-cell Function in IDDM

Alicia Schiffrin, MD, Samy Suissa, PHD, Gabriel Weitzner, BSC, Philippe Poussier, MD, Daniel Lalla, MD
Journal: Diabetes Care
Diabetes Care 1992;15(8):997–1001
https://doi.org/10.2337/diacare.15.8.997
Published: 01 August 1992
View article titled, Factors Predicting Course of β-cell Function in IDDM
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Journal Articles

Severe Hypoglycemia in IDDM Children

Ignacio Bergada, MD, Samy Suissa, PhD, Jackie Dufresne, RN, Alicia Schiffrin, MD
Journal: Diabetes Care
Diabetes Care 1989;12(4):239–244
https://doi.org/10.2337/diacare.12.4.239
Published: 01 April 1989
View article titled, Severe Hypoglycemia in IDDM Children
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