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Trevor J. Orchard
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Journal Articles

Neuropathic Pain With and Without Diabetic Peripheral Neuropathy in Type 1 Diabetes

Barbara H. Braffett, Laure El ghormli, James W. Albers, Eva L. Feldman, William H. Herman, Rose A. Gubitosi-Klug, Catherine L. Martin, Trevor J. Orchard, Neil H. White, John M. Lachin, Bruce A. Perkins, Rodica Pop-Busui, DCCT/EDIC Research Group
Journal: Diabetes Care
Diabetes Care 2024;47(9):1559–1567
https://doi.org/10.2337/dc23-1749
Published: 01 February 2024
View article titled, Neuropathic Pain With and Without Diabetic Peripheral Neuropathy in Type 1 Diabetes
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Journal Articles

Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes

Christine P. Limonte, Erkka Valo, Viktor Drel, Loki Natarajan, Manjula Darshi, Carol Forsblom, Clark M. Henderson, Andrew N. Hoofnagle, Wenjun Ju, Matthias Kretzler, Daniel Montemayor, Viji Nair, Robert G. Nelson, John F. O’Toole, Robert D. Toto, Sylvia E. Rosas, John Ruzinski, Niina Sandholm, Insa M. Schmidt, Tomas Vaisar, Sushrut S. Waikar, Jing Zhang, Peter Rossing, Tarunveer S. Ahluwalia, Per-Henrik Groop, Subramaniam Pennathur, Janet K. Snell-Bergeon, Tina Costacou, Trevor J. Orchard, Kumar Sharma, Ian H. de Boer, for the Kidney Precision Medicine Project
Journal: Diabetes Care
Diabetes Care 2022;45(6):1416–1427
https://doi.org/10.2337/dc21-2204
Published: 04 April 2022
View article titled, Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
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Journal Articles

30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-term Patterns of Glycemic Control

Rachel G. Miller, Trevor J. Orchard, Tina Costacou
Journal: Diabetes Care
Diabetes Care 2022;45(1):142–150
https://doi.org/10.2337/dc21-1381
Published: 15 November 2021
View article titled, 30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-term Patterns of Glycemic Control
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Journal Articles

Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes

Farsad Afshinnia, Thekkelnaycke M. Rajendiran, Chenchen He, Jaeman Byun, Daniel Montemayor, Manjula Darshi, Jana Tumova, Jiwan Kim, Christine P. Limonte, Rachel G. Miller, Tina Costacou, Trevor J. Orchard, Tarunveer S. Ahluwalia, Peter Rossing, Janet K. Snell-Bergeon, Ian H. de Boer, Loki Natarajan, George Michailidis, Kumar Sharma, Subramaniam Pennathur
Journal: Diabetes Care
Diabetes Care 2021;44(9):2098–2106
https://doi.org/10.2337/dc21-0737
Published: 08 July 2021
View article titled, Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes
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Journal Articles

Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study

Ionut Bebu, Sareh Keshavarzi, Xiaoyu Gao, Barbara H. Braffett, Angelo J. Canty, William H. Herman, Trevor J. Orchard, Samuel Dagogo-Jack, David M. Nathan, John M. Lachin, Andrew D. Paterson
Journal: Diabetes Care
Diabetes Care 2021;44(6):1309–1316
https://doi.org/10.2337/dc20-2388
Published: 21 April 2021
View article titled, Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study
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Journal Articles

Risk Factors for Longitudinal Resting Heart Rate and Its Associations With Cardiovascular Outcomes in the DCCT/EDIC Study

Sareh Keshavarzi, Barbara H. Braffett, Rodica Pop-Busui, Trevor J. Orchard, Elsayed Z. Soliman, Gayle M. Lorenzi, Annette Barnie, Amy B. Karger, Rose A. Gubitosi-Klug, Samuel Dagogo-Jack, Andrew D. Paterson, the DCCT/EDIC Research Group
Journal: Diabetes Care
Diabetes Care 2021;44(5):1125–1132
https://doi.org/10.2337/dc20-2387
Published: 25 February 2021
View article titled, Risk Factors for Longitudinal Resting Heart Rate and Its Associations With Cardiovascular Outcomes in the DCCT/EDIC Study
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Journal Articles

High-Sensitivity Cardiac Troponin-T and N-Terminal Prohormone of B-Type Natriuretic Peptide in Relation to Cardiovascular Outcomes in Type 1 Diabetes

Tina Costacou, Amy K. Saenger, Trevor J. Orchard
Journal: Diabetes Care
Diabetes Care 2020;43(9):2199–2207
https://doi.org/10.2337/dc20-0359
Published: 02 July 2020
View article titled, High-Sensitivity Cardiac Troponin-T and N-Terminal Prohormone of B-Type Natriuretic Peptide in Relation to Cardiovascular Outcomes in Type 1 Diabetes
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Journal Articles

Optimal Blood Pressure Thresholds for Minimal Coronary Artery Disease Risk in Type 1 Diabetes

Jingchuan Guo, Maria M. Brooks, Matthew F. Muldoon, Ashely I. Naimi, Trevor J. Orchard, Tina Costacou
Journal: Diabetes Care
Diabetes Care 2019;42(9):1692–1699
https://doi.org/10.2337/dc19-0480
Published: 27 June 2019
View article titled, Optimal Blood Pressure Thresholds for Minimal Coronary Artery Disease Risk in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Mediation of the Effect of Glycemia on the Risk of CVD Outcomes in Type 1 Diabetes: The DCCT/EDIC Study

Ionut Bebu, Barbara H. Braffett, Trevor J. Orchard, Gayle M. Lorenzi, John M. Lachin, the DCCT/EDIC Research Group
Journal: Diabetes Care
Diabetes Care 2019;42(7):1284–1289
https://doi.org/10.2337/dc18-1613
Published: 20 March 2019
View article titled, Mediation of the Effect of Glycemia on the Risk of CVD Outcomes in Type 1 Diabetes: The DCCT/EDIC Study
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Includes: Supplementary data
Journal Articles

Aspects of Multicomponent Integrated Care Promote Sustained Improvement in Surrogate Clinical Outcomes: A Systematic Review and Meta-analysis

Lee Ling Lim, Eric S.H. Lau, Alice P.S. Kong, Melanie J. Davies, Naomi S. Levitt, Björn Eliasson, Carlos A. Aguilar-Salinas, Guang Ning, Yutaka Seino, Wing Yee So, Margaret McGill, Graham D. Ogle, Trevor J. Orchard, Philip Clarke, Rury R. Holman, Edward W. Gregg, Juan José Gagliardino, Juliana C.N. Chan
Journal: Diabetes Care
Diabetes Care 2018;41(6):1312–1320
https://doi.org/10.2337/dc17-2010
Published: 11 May 2018
View article titled, Aspects of Multicomponent Integrated Care Promote Sustained Improvement in Surrogate Clinical Outcomes: A Systematic Review and Meta-analysis
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Includes: Supplementary data
Journal Articles

Cumulative Kidney Complication Risk by 50 Years of Type 1 Diabetes: The Effects of Sex, Age, and Calendar Year at Onset

Tina Costacou, Trevor J. Orchard
Journal: Diabetes Care
Diabetes Care 2018;41(3):426–433
https://doi.org/10.2337/dc17-1118
Published: 20 September 2017
View article titled, Cumulative Kidney Complication Risk by 50 Years of Type 1 Diabetes: The Effects of Sex, Age, and Calendar Year at Onset
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Includes: Supplementary data
Journal Articles

Electrocardiographic Abnormalities and Cardiovascular Disease Risk in Type 1 Diabetes: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study

Elsayed Z. Soliman, Jye-Yu C. Backlund, Ionut Bebu, Trevor J. Orchard, Bernard Zinman, John M. Lachin, the DCCT/EDIC Research Group
Journal: Diabetes Care
Diabetes Care 2017;40(6):793–799
https://doi.org/10.2337/dc16-2050
Published: 16 March 2017
View article titled, Electrocardiographic Abnormalities and Cardiovascular Disease Risk in Type 1 Diabetes: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study
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Includes: Supplementary data
Journal Articles

A Contemporary Estimate of Total Mortality and Cardiovascular Disease Risk in Young Adults With Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study

Rachel G. Miller, Hemant D. Mahajan, Tina Costacou, Akira Sekikawa, Stewart J. Anderson, Trevor J. Orchard
Journal: Diabetes Care
Diabetes Care 2016;39(12):2296–2303
https://doi.org/10.2337/dc16-1162
Published: 21 September 2016
View article titled, A Contemporary Estimate of Total Mortality and Cardiovascular Disease Risk in Young Adults With Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study
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Includes: Supplementary data
Journal Articles

Response to Comment on Nunley et al. Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes. Diabetes Care 2015;38:1768–1776

Karen A. Nunley, Christopher M. Ryan, Judith A. Saxton, Tina Costacou, Trevor J. Orchard, Caterina Rosano
Journal: Diabetes Care
Diabetes Care 2016;39(2):e25
https://doi.org/10.2337/dci15-0028
Published: 12 January 2016
View article titled, Response to Comment on Nunley et al. Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes. Diabetes Care 2015;38:1768–1776
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Journal Articles

Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report

Diane K. Wherrett, Jane L. Chiang, Alan M. Delamater, Linda A. DiMeglio, Stephen E. Gitelman, Peter A. Gottlieb, Kevan C. Herold, Daniel J. Lovell, Trevor J. Orchard, Christopher M. Ryan, Desmond A. Schatz, David S. Wendler, Carla J. Greenbaum, the Type 1 Diabetes TrialNet Study Group
Journal: Diabetes Care
Diabetes Care 2015;38(10):1975–1985
https://doi.org/10.2337/dc15-1429
Published: 15 September 2015
View article titled, Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report
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Includes: Supplementary data
Journal Articles

Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes

Karen A. Nunley, Caterina Rosano, Christopher M. Ryan, J. Richard Jennings, Howard J. Aizenstein, Janice C. Zgibor, Tina Costacou, Robert M. Boudreau, Rachel Miller, Trevor J. Orchard, Judith A. Saxton
Journal: Diabetes Care
Diabetes Care 2015;38(9):1768–1776
https://doi.org/10.2337/dc15-0041
Published: 07 July 2015
View article titled, Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association

Sarah D. de Ferranti, MD, MPH, Ian H. de Boer, MD, MS, Vivian Fonseca, MD, Caroline S. Fox, MD, MPH, Sherita Hill Golden, MD, MHS, Carl J. Lavie, MD, Sheela N. Magge, MD, MSCE, Nikolaus Marx, MD, Darren K. McGuire, MD, Trevor J. Orchard, MD, MMedSci, Bernard Zinman, MD, Robert H. Eckel, MD, FAHA
Journal: Diabetes Care
Diabetes Care 2014;37(10):2843–2863
https://doi.org/10.2337/dc14-1720
Published: 10 September 2014
View article titled, Type 1 Diabetes Mellitus and Cardiovascular Disease: A Scientific Statement From the American Heart Association and American Diabetes Association
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Includes: Supplementary data
Journal Articles

Regression From Prediabetes to Normal Glucose Regulation Is Associated With Reduction in Cardiovascular Risk: Results From the Diabetes Prevention Program Outcomes Study

Leigh Perreault, Marinella Temprosa, Kieren J. Mather, Ed Horton, Abbas Kitabchi, Mary Larkin, Maria G. Montez, Debra Thayer, Trevor J. Orchard, Richard F. Hamman, Ronald B. Goldberg, for the Diabetes Prevention Program Research Group
Journal: Diabetes Care
Diabetes Care 2014;37(9):2622–2631
https://doi.org/10.2337/dc14-0656
Published: 07 August 2014
View article titled, Regression From Prediabetes to Normal Glucose Regulation Is Associated With Reduction in Cardiovascular Risk: Results From the Diabetes Prevention Program Outcomes Study
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Includes: Supplementary data
Journal Articles

Lifestyle and Metformin Interventions Have a Durable Effect to Lower CRP and tPA Levels in the Diabetes Prevention Program Except in Those Who Develop Diabetes

Ronald B. Goldberg, Marinella G. Temprosa, Kieren J. Mather, Trevor J. Orchard, Abbas E. Kitabchi, Karol E. Watson, for the Diabetes Prevention Program Research Group
Journal: Diabetes Care
Diabetes Care 2014;37(8):2253–2260
https://doi.org/10.2337/dc13-2471
Published: 12 July 2014
View article titled, Lifestyle and Metformin Interventions Have a Durable Effect to Lower CRP and tPA Levels in the Diabetes Prevention Program Except in Those Who Develop Diabetes
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Includes: Supplementary data
Journal Articles

Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

John M. Lachin, Trevor J. Orchard, David M. Nathan, for the DCCT/EDIC Research Group
Journal: Diabetes Care
Diabetes Care 2014;37(1):39–43
https://doi.org/10.2337/dc13-2116
Published: 11 December 2013
View article titled, Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
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