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Journal Articles

Aldose Reductase Genotypes and Cardiorenal Complications: An 8-year prospective analysis of 1,074 type 2 diabetic patients

Wing-Yee So, MBCHB, FRCP, Ying Wang, PHD, Maggie C.Y. Ng, BSC, PHD, Xilin Yang, PHD, Ronald C.W. Ma, MBBCHIR, MRCP, Vincent Lam, BSC, MPHIL, Alice P.S. Kong, MBCHB, FRCP, Peter C.Y. Tong, PHD, FRCP, Juliana C.N. Chan, MD, FRCP
Journal: Diabetes Care
Diabetes Care 2008;31(11):2148–2153
https://doi.org/10.2337/dc08-0712
Published: 01 November 2008
View article titled, Aldose Reductase Genotypes and Cardiorenal Complications: <subtitle>An 8-year prospective analysis of 1,074 type 2 diabetic patients</subtitle>
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Journal Articles

Decline in Neurophysiological Function After 7 Years in an Adolescent Diabetic Cohort and the Role of Aldose Reductase Gene Polymorphisms

Keerthi Thamotharampillai, GMEDSC, Albert K.F. Chan, MAPPSTAT, Bruce Bennetts, PHD, Maria E. Craig, PHD, Janine Cusumano, Martin Silink, MD, Peter J. Oates, PHD, Kim C. Donaghue, PHD
Journal: Diabetes Care
Diabetes Care 2006;29(9):2053–2057
https://doi.org/10.2337/dc06-0678
Published: 01 September 2006
View article titled, Decline in Neurophysiological Function After 7 Years in an Adolescent Diabetic Cohort and the Role of Aldose Reductase Gene Polymorphisms
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Journal Articles

Long-Term Clinical Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Peripheral Neuropathy: The 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial

Nigishi Hotta, MD, Yasuo Akanuma, MD, Ryuzo Kawamori, MD, Kempei Matsuoka, MD, Yoshitomo Oka, MD, Motoaki Shichiri, MD, Takayoshi Toyota, MD, Mitsuyoshi Nakashima, MD, Isao Yoshimura, PHD, Nobuo Sakamoto, MD, Yukio Shigeta, MD, the ADCT Study Group
Journal: Diabetes Care
Diabetes Care 2006;29(7):1538–1544
https://doi.org/10.2337/dc05-2370
Published: 01 July 2006
View article titled, Long-Term Clinical Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Peripheral Neuropathy: <subtitle>The 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial</subtitle>
Open the PDF for Long-Term Clinical Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Peripheral Neuropathy: <subtitle>The 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial</subtitle> in another window
Journal Articles

Diabetes and Advanced Glycoxidation End Products

Amy G. Huebschmann, MD, Judith G. Regensteiner, PHD, Helen Vlassara, MD, Jane E.B. Reusch, MD
Journal: Diabetes Care
Diabetes Care 2006;29(6):1420–1432
https://doi.org/10.2337/dc05-2096
Published: 01 June 2006
View article titled, Diabetes and Advanced Glycoxidation End Products
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Journal Articles

Long-Term Effects of Ranirestat (AS-3201) on Peripheral Nerve Function in Patients With Diabetic Sensorimotor Polyneuropathy

Vera Bril, MD, FRCPC, Robert A. Buchanan, MD, the Ranirestat Study Group*
Journal: Diabetes Care
Diabetes Care 2006;29(1):68–72
https://doi.org/10.2337/diacare.29.01.06.dc05-1447
Published: 01 January 2006
View article titled, Long-Term Effects of Ranirestat (AS-3201) on Peripheral Nerve Function in Patients With Diabetic Sensorimotor Polyneuropathy
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Journal Articles

Aldose Reductase Inhibition by AS-3201 in Sural Nerve From Patients With Diabetic Sensorimotor Polyneuropathy

Vera Bril, MD, Robert A. Buchanan, MD, the AS-3201 Study Group
Journal: Diabetes Care
Diabetes Care 2004;27(10):2369–2375
https://doi.org/10.2337/diacare.27.10.2369
Published: 01 October 2004
View article titled, Aldose Reductase Inhibition by AS-3201 in Sural Nerve From Patients With Diabetic Sensorimotor Polyneuropathy
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Journal Articles

Aldose Reductase Gene Polymorphisms and Peripheral Nerve Function in Patients With Type 2 Diabetes

Katariina Sivenius, MD, Jussi Pihlajamäki, MD, Juhani Partanen, MD, Leo Niskanen, MD, Markku Laakso, MD, Matti Uusitupa, MD
Journal: Diabetes Care
Diabetes Care 2004;27(8):2021–2026
https://doi.org/10.2337/diacare.27.8.2021
Published: 01 August 2004
View article titled, Aldose Reductase Gene Polymorphisms and Peripheral Nerve Function in Patients With Type 2 Diabetes
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Journal Articles

Natural Progression of Diabetic Peripheral Neuropathy in the Zenarestat Study Population

Mark J. Brown, MD, Shawn J. Bird, MD, Sharon Watling, PHARMD, Hong Kaleta, MS, Lee Hayes, BSC, Stephen Eckert, PHD, Howard L. Foyt, MD, PHD
Journal: Diabetes Care
Diabetes Care 2004;27(5):1153–1159
https://doi.org/10.2337/diacare.27.5.1153
Published: 01 May 2004
View article titled, Natural Progression of Diabetic Peripheral Neuropathy in the Zenarestat Study Population
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Journal Articles

Sural Nerve Sorbitol in Patients With Diabetic Sensorimotor Polyneuropathy

Vera Bril, MD, Yoshiyuki Ono, MSC, Robert A. Buchanan, MD
Journal: Diabetes Care
Diabetes Care 2004;27(5):1160–1163
https://doi.org/10.2337/diacare.27.5.1160
Published: 01 May 2004
View article titled, Sural Nerve Sorbitol in Patients With Diabetic Sensorimotor Polyneuropathy
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Journal Articles

Cardiac Abnormalities in Diabetic Patients With Neuropathy: Effects of aldose reductase inhibitor administration

Brian F. Johnson, MD, Richard W. Nesto, MD, Michael A. Pfeifer, MD, William R. Slater, MD, FACC, Aaron I. Vinik, MD, Deborah A. Chyun, RN, PHD, Gordon Law, PHD, Frans J.Th. Wackers, MD, Lawrence H. Young, MD
Journal: Diabetes Care
Diabetes Care 2004;27(2):448–454
https://doi.org/10.2337/diacare.27.2.448
Published: 01 February 2004
View article titled, Cardiac Abnormalities in Diabetic Patients With Neuropathy: <subtitle>Effects of aldose reductase inhibitor administration </subtitle>
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Journal Articles

Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes: Response to Ng et al.

Juliana Chan, MD, FRCP, Ying Wang, PHD
Journal: Diabetes Care
Diabetes Care 2004;27(1):290
https://doi.org/10.2337/diacare.27.1.290
Published: 01 January 2004
View article titled, Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes: <subtitle>Response to Ng et al.</subtitle>
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Journal Articles

Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes: Response to Wang et al.

Daniel P.K. Ng, PHD, Kee-Seng Chia, FAMS, MD, FFOM, David Koh, MBBS, MSC, PHD
Journal: Diabetes Care
Diabetes Care 2004;27(1):289–290
https://doi.org/10.2337/diacare.27.1.289
Published: 01 January 2004
View article titled, Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes: <subtitle>Response to Wang et al.</subtitle>
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Journal Articles

Association of the p22phox Component of NAD(P)H Oxidase With Susceptibility to Diabetic Nephropathy in Patients With Type 1 Diabetes

Andrea D. Hodgkinson, PHD, Beverley A. Millward, MD, Andrew G. Demaine, PHD
Journal: Diabetes Care
Diabetes Care 2003;26(11):3111–3115
https://doi.org/10.2337/diacare.26.11.3111
Published: 01 November 2003
View article titled, Association of the p22phox Component of NAD(P)H Oxidase With Susceptibility to Diabetic Nephropathy in Patients With Type 1 Diabetes
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Journal Articles

Diabetic Retinopathy and Diabetic Macular Edema: Pathophysiology, screening, and novel therapies

Thomas A. Ciulla, MD, Armando G. Amador, MD, Bernard Zinman, MDCM, FRCP(C), FACP
Journal: Diabetes Care
Diabetes Care 2003;26(9):2653–2664
https://doi.org/10.2337/diacare.26.9.2653
Published: 01 September 2003
View article titled, Diabetic Retinopathy and Diabetic Macular Edema: <subtitle>Pathophysiology, screening, and novel therapies</subtitle>
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Journal Articles

Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes

Ying Wang, MD, CHB, Maggie C.Y. Ng, BSC, PHD, Shao-Chin Lee, PHD, Wing-Yee So, MBCHB, MRCP, Peter C.Y. Tong, MBCHB, MRCP, Clive S. Cockram, MD, FRCP, Julian A.J.H. Critchley, PHD, FRCP, Juliana C.N. Chan, MD, FRCP
Journal: Diabetes Care
Diabetes Care 2003;26(8):2410–2415
https://doi.org/10.2337/diacare.26.8.2410
Published: 01 August 2003
View article titled, Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes
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Journal Articles

Errata

Journal: Diabetes Care
Diabetes Care 2002;25(2):413–414
https://doi.org/10.2337/diacare.25.2.413
Published: 01 February 2002
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Journal Articles

Clinical Efficacy of Fidarestat, a Novel Aldose Reductase Inhibitor, for Diabetic Peripheral Neuropathy: A 52-week multicenter placebo-controlled double-blind parallel group study

Nigishi Hotta, MD, Takayoshi Toyota, MD, Kempei Matsuoka, MD, Yukio Shigeta, MD, Ryuichi Kikkawa, MD, Toshio Kaneko, MD, Akira Takahashi, MD, Kimiya Sugimura, MD, Yasuo Koike, MD, Jun Ishii, MD, Nobuo Sakamoto, MD, The SNK-860 Diabetic Neuropathy Study Group
Journal: Diabetes Care
Diabetes Care 2001;24(10):1776–1782
https://doi.org/10.2337/diacare.24.10.1776
Published: 01 October 2001
View article titled, Clinical Efficacy of Fidarestat, a Novel Aldose Reductase Inhibitor, for Diabetic Peripheral Neuropathy: <subtitle>A 52-week multicenter placebo-controlled double-blind parallel group study</subtitle>
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Journal Articles

Aldose Reductase Inhibition Ameliorates Pupillary Light Reflex and F-Wave Latency in Patients With Mild Diabetic Neuropathy

Mikihiro Nakayama, MD, Jiro Nakamura, MD, Yoji Hamada, MD, Sadao Chaya, MD, Ryuichi Mizubayashi, MD, Yutaka Yasuda, MD, Hideki Kamiya, MD, Naoki Koh, MD, Nigishi Hotta, MD
Journal: Diabetes Care
Diabetes Care 2001;24(6):1093–1098
https://doi.org/10.2337/diacare.24.6.1093
Published: 01 June 2001
View article titled, Aldose Reductase Inhibition Ameliorates Pupillary Light Reflex and F-Wave Latency in Patients With Mild Diabetic Neuropathy
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Meeting Abstracts

Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients.

Y Hamada, J Nakamura, K Naruse, T Komori, K Kato, Y Kasuya, R Nagai, S Horiuchi, N Hotta
Journal: Diabetes Care
Diabetes Care 2000;23(10):1539–1544
https://doi.org/10.2337/diacare.23.10.1539
Published: 01 October 2000
View article titled, Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients.
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Meeting Abstracts

Effect of aldose reductase inhibitor on cutaneous nerve fiber length in diabetic patients.

H Yasuda, A Hirai, M Joko, M Terada, T Kawabata, K Maeda, M Haneda, A Kashiwagi, T Maeda, R Kikkawa
Journal: Diabetes Care
Diabetes Care 2000;23(5):705
https://doi.org/10.2337/diacare.23.5.705b
Published: 01 May 2000
View article titled, Effect of aldose reductase inhibitor on cutaneous nerve fiber length in diabetic patients.
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