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Journal Articles

The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes

Klara R. Klein, Jennifer L.R. Freeman, Imogene Dunn, Chris Dvergsten, M. Sue Kirkman, John B. Buse, Carmen Valcarce, SimpliciT1 research group, John B. Buse, Klara R. Klein, M. Sue Kirkman, Katherine A. Bergamo, Elizabeth H. Harris, Jean M. Dostou, Laura A. Young, Sriram Machineni, Alex M. Kass, Jamie C. Diner, Milana Dezube, Virginia C. Purrington, Julie M. Uehling, Rachael M. Fraser, Katherine R. Schuch, Jennifer V. Rowell, Ali Qamar, K. Jean Lucas, Luke Snedaker, Stephanie Hoover, Justin Smith, Paul Becton, Jeffrey Hainsworth, Timothy S. Bailey, Juan Pablo Garcia-Naranjo, Niki Nguyen, Bruce W. Bode, Jennifer M. Boyd, Betsy Childs, Pablo Mora, Allison Camacho, Carl D. Vance, Karen Lugo, Anuj Bhargava, Kirstie Stifel, Lisa B. Connery, Birjis Khan, Simone D. Smith, John Parker, Kathryn Zweier, Emily Kronenfeld, Brittany Savoca, Viral N. Shah, Prakriti Joshee, Shivani Dixit, Hal Joseph, Halis Kaan Akturk, Subbulaxami Trikudanathan, Dori Khakpour, Julia Chang, Anne Peters, Pejman Cohan, Mark Harmel, Wendy S . Lane
Journal: Diabetes Care
Diabetes Care 2021;44(4):960–968
https://doi.org/10.2337/dc20-2684
Published: 23 February 2021
View article titled, The SimpliciT1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2 Adaptive Study of TTP399, a Hepatoselective Glucokinase Activator, for Adjunctive Treatment of Type 1 Diabetes
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Journal Articles

Pharmacokinetic and Pharmacodynamic Head-to-Head Comparison of Clinical, Equivalent Doses of Insulin Glargine 300 units · mL−1 and Insulin Degludec 100 units · mL−1 in Type 1 Diabetes

Paola Lucidi, Paola Candeloro, Patrizia Cioli, Anna Marinelli Andreoli, Chiara Pascucci, Angela Gambelunghe, Geremia B. Bolli, Carmine G. Fanelli, Francesca Porcellati
Journal: Diabetes Care
Diabetes Care 2021;44(1):125–132
https://doi.org/10.2337/dc20-1033
Published: 10 November 2020
View article titled, Pharmacokinetic and Pharmacodynamic Head-to-Head Comparison of Clinical, Equivalent Doses of Insulin Glargine 300 units · mL<sup>−1</sup> and Insulin Degludec 100 units · mL<sup>−1</sup> in Type 1 Diabetes
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Journal Articles

Nutritional Lifestyle Intervention in Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-β-Hydroxybutyrate, and Fasting Glucose Concentrations: A Secondary Factorial Analysis of the European Multicenter, Randomized Controlled DALI Lifestyle Intervention Trial

Jürgen Harreiter, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M. Adelantado, Roland Devlieger, Sander Galjaard, Peter Damm, Elisabeth R. Mathiesen, Dorte M. Jensen, Lise Lotte T. Andersen, Fidelma Dunne, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, Urszula Mantaj, David Hill, Judith G.M. Jelsma, Frank J. Snoek, Michael Leutner, Christian Lackinger, Christof Worda, Dagmar Bancher-Todesca, Hubert Scharnagl, Mireille N.M. van Poppel, Alexandra Kautzky-Willer
Journal: Diabetes Care
Diabetes Care 2019;42(8):1380–1389
https://doi.org/10.2337/dc19-0418
Published: 10 June 2019
View article titled, Nutritional Lifestyle Intervention in Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-β-Hydroxybutyrate, and Fasting Glucose Concentrations: A Secondary Factorial Analysis of the European Multicenter, Randomized Controlled DALI Lifestyle Intervention Trial
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Includes: Supplementary data
Journal Articles

Response to Comment on Ferrannini et al. CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis. Diabetes Care 2016;39:1108–1114

Ele Ferrannini, Michael Mark, Eric Mayoux
Journal: Diabetes Care
Diabetes Care 2016;39(12):e226
https://doi.org/10.2337/dci16-0033
Published: 10 November 2016
View article titled, Response to Comment on Ferrannini et al. CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis. Diabetes Care 2016;39:1108–1114
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Journal Articles

Response to Comment on Ferrannini et al. Diabetes Care 2016;39:1108–1114. Comment on Mudaliar et al. Diabetes Care 2016;39:1115–1122

Ele Ferrannini, Michael Mark, Eric Mayoux
Journal: Diabetes Care
Diabetes Care 2016;39(11):e196–e197
https://doi.org/10.2337/dci16-0027
Published: 11 October 2016
View article titled, Response to Comment on Ferrannini et al. Diabetes Care 2016;39:1108–1114. Comment on Mudaliar et al. Diabetes Care 2016;39:1115–1122
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Journal Articles

CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis

Ele Ferrannini, Michael Mark, Eric Mayoux
Journal: Diabetes Care
Diabetes Care 2016;39(7):1108–1114
https://doi.org/10.2337/dc16-0330
Published: 11 June 2016
View article titled, CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis
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Journal Articles

A Low–Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes

Matthew D. Campbell, Mark Walker, Michael I. Trenell, Emma J. Stevenson, Daniel Turner, Richard M. Bracken, James A. Shaw, Daniel J. West
Journal: Diabetes Care
Diabetes Care 2014;37(7):1845–1853
https://doi.org/10.2337/dc14-0186
Published: 12 June 2014
View article titled, A Low–Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Safety of Nighttime 2-Hour Suspension of Basal Insulin in Pump-Treated Type 1 Diabetes Even in the Absence of Low Glucose

Jennifer L. Sherr, Miladys Palau Collazo, Eda Cengiz, Camille Michaud, Lori Carria, Amy T. Steffen, Kate Weyman, Melinda Zgorski, Eileen Tichy, William V. Tamborlane, Stuart A. Weinzimer
Journal: Diabetes Care
Diabetes Care 2014;37(3):773–779
https://doi.org/10.2337/dc13-1608
Published: 11 February 2014
View article titled, Safety of Nighttime 2-Hour Suspension of Basal Insulin in Pump-Treated Type 1 Diabetes Even in the Absence of Low Glucose
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Journal Articles

Can Serum β-Hydroxybutyrate Be Used to Diagnose Diabetic Ketoacidosis?

Mae Sheikh-Ali, MD, Brad S. Karon, MD, PHD, Ananda Basu, MB, BS, Yogish C. Kudva, MB, BS, Lisa A. Muller, BA, Jia Xu, MS, W. Frederick Schwenk, MD, John M. Miles, MD
Journal: Diabetes Care
Diabetes Care 2008;31(4):643–647
https://doi.org/10.2337/dc07-1683
Published: 01 April 2008
View article titled, Can Serum β-Hydroxybutyrate Be Used to Diagnose Diabetic Ketoacidosis?
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Includes: Supplementary data
Journal Articles

Accuracy of an Electrochemical Sensor for Measuring Capillary Blood Ketones by Fingerstick Samples During Metabolic Deterioration After Continuous Subcutaneous Insulin Infusion Interruption in Type 1 Diabetic Patients

Bruno Guerci, MD, PHD, Muriel Benichou, MD, Michèle Floriot, MD, Philip Bohme, MD, Sebastien Fougnot, MD, Patricia Franck, MD, Pierre Drouin, MD
Journal: Diabetes Care
Diabetes Care 2003;26(4):1137–1141
https://doi.org/10.2337/diacare.26.4.1137
Published: 01 April 2003
View article titled, Accuracy of an Electrochemical Sensor for Measuring Capillary Blood Ketones by Fingerstick Samples During Metabolic Deterioration After Continuous Subcutaneous Insulin Infusion Interruption in Type 1 Diabetic Patients
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Journal Articles

Cost Effectiveness of the Direct Measurement of 3-β-Hydroxybutyrate in the Management of Diabetic Ketoacidosis in Children

Maurizio Vanelli, MD, Giovanni Chiari, MD, Ciro Capuano, MD
Journal: Diabetes Care
Diabetes Care 2003;26(3):959
https://doi.org/10.2337/diacare.26.3.959
Published: 01 March 2003
View article titled, Cost Effectiveness of the Direct Measurement of 3-β-Hydroxybutyrate in the Management of Diabetic Ketoacidosis in Children
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Meeting Abstracts

Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.

S K Jain, R McVie, R Jackson, S N Levine, G Lim
Journal: Diabetes Care
Diabetes Care 1999;22(7):1171–1175
https://doi.org/10.2337/diacare.22.7.1171
Published: 01 July 1999
View article titled, Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.
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Meeting Abstracts

The Diabetes in Early Pregnancy Study: beta-hydroxybutyrate levels in type 1 diabetic pregnancy compared with normal pregnancy. NICHD-Diabetes in Early Pregnancy Study Group (DIEP). National Institute of Child Health and Development.

L Jovanovic, B E Metzger, R H Knopp, M R conley, E Park, Y J Lee, J L Simpson, L Holmes, J H Aarons, J L Mills
Journal: Diabetes Care
Diabetes Care 1998;21(11):1978–1984
https://doi.org/10.2337/diacare.21.11.1978
Published: 01 November 1998
View article titled, The Diabetes in Early Pregnancy Study: beta-hydroxybutyrate levels in type 1 diabetic pregnancy compared with normal pregnancy. NICHD-Diabetes in Early Pregnancy Study Group (DIEP). National Institute of Child Health and Development.
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Journal Articles

Treatment of Diabetic Ketoacidosis Using Normalization of Blood 3-Hydroxybutyrate Concentration as the Endpoint of Emergency Management: A randomized controlled study

M Ivan Wiggam, MRCP, Maurice J O'Kane, MD, Roy Harper, MD, A Brew Atkinson, MD, David R Hadden, MD, Elisabeth R Trimble, MD, Patrick M Bell, MD
Journal: Diabetes Care
Diabetes Care 1997;20(9):1347–1352
https://doi.org/10.2337/diacare.20.9.1347
Published: 01 September 1997
View article titled, Treatment of Diabetic Ketoacidosis Using Normalization of Blood 3-Hydroxybutyrate Concentration as the Endpoint of Emergency Management: A randomized controlled study
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Journal Articles

Clinical Utility of β3-Hydroxybutyrate Determined by Reflectance Meter in the Management of Diabetic Ketoacidosis

Guillermo E Umpierrez, MD, Nelson B Watts, MD, Lawrence S Phillips, MD
Journal: Diabetes Care
Diabetes Care 1995;18(1):137–138
https://doi.org/10.2337/diacare.18.1.137
Published: 01 January 1995
View article titled, Clinical Utility of β3-Hydroxybutyrate Determined by Reflectance Meter in the Management of Diabetic Ketoacidosis
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Journal Articles

Evidence for a Role for Insulin and Growth Hormone in Overnight Regulation of 3-Hydroxybutyrate in Normal and Diabetic Adolescents

Julie A Edge, MRCP, Dorothy A Harris, FIMLS, Paula E Phillips, B Rani Pal, MRCP, David R Matthews, David B Dunger, MD
Journal: Diabetes Care
Diabetes Care 1993;16(7):1011–1018
https://doi.org/10.2337/diacare.16.7.1011
Published: 01 July 1993
View article titled, Evidence for a Role for Insulin and Growth Hormone in Overnight Regulation of 3-Hydroxybutyrate in Normal and Diabetic Adolescents
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Journal Articles

Development of Stable Film Test for Rapid Estimation of Blood or Plasma 3-Hydroxybutyrate

Yutaka Harano, MD, PhD, Takahiko Aoki, MD, Yuzuru Nakajima, MD, Hideto Kojima, MD, PhD, Keisuke Kosugi, MD, PhD, Aki Harano, MD, Hideki Hidaka, MD, PhD, Shigeki Yamada, MS, Shizuo Uno, MS, Yukio Shigeta, MD, PhD
Journal: Diabetes Care
Diabetes Care 1990;13(5):522–524
https://doi.org/10.2337/diacare.13.5.522
Published: 01 May 1990
View article titled, Development of Stable Film Test for Rapid Estimation of Blood or Plasma 3-Hydroxybutyrate
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Journal Articles

Metabolic and Hormonal Changes in IDDM During Long-Distance Run

Arend E Meinders, MD, PhD, Frans L A Willekens, PhD, Leo P Heere, MD
Journal: Diabetes Care
Diabetes Care 1988;11(1):1–7
https://doi.org/10.2337/diacare.11.1.1
Published: 01 January 1988
View article titled, Metabolic and Hormonal Changes in IDDM During Long-Distance Run
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Journal Articles

Development of Paper-strip Test for 3-Hydroxybutyrate and its Clinical Application

Yutaka Harano, M.D., Masaaki Suzuki, M.D., Hideto Kojima, M.D., Atsunori Kashiwagi, M.D. Ph.D., Hideki Hidaka, M.D. Ph.D., Yukio Shigeta, M.D. Ph.D.
Journal: Diabetes Care
Diabetes Care 1984;7(5):481–485
https://doi.org/10.2337/diacare.7.5.481
Published: 01 September 1984
View article titled, Development of Paper-strip Test for 3-Hydroxybutyrate and its Clinical Application
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Journal Articles

Can β-Hydroxybutyrate Be Detected at the Bedside by In Vitro Oxidation with Hydrogen Peroxide?

James R Oster, M.D., Barbara Rietberg, B.S., Andrew L Taylor, M.D., Guido O Perez, M.D., Rajiv Chandra, M.D., Laurence B Gardner, M.D.
Journal: Diabetes Care
Diabetes Care 1984;7(1):80–82
https://doi.org/10.2337/diacare.7.1.80
Published: 01 January 1984
View article titled, Can β-Hydroxybutyrate Be Detected at the Bedside by In Vitro Oxidation with Hydrogen Peroxide?
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