Search Results for fatty acids

...; Michael Y. Tsai; Renata Micha; Dariush Mozaffarian; the Fatty Acids and Outcomes Research Consortium (FORCE) OBJECTIVE Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate...

... glucose uptake lower with dapagliflozin than placebo. Plasma β-hydroxybutyrate (BOHB) concentrations and [¹³C₂]BOHB concentrations were higher and glucose concentrations lower with dapagliflozin than placebo. Nonesterified fatty acids (NEFAs) were higher with dapagliflozin at 300...

...Meena Shah, PHD; Beverley Adams-Huet, MS; Linda Brinkley, RD; Scott M. Grundy, MD, PHD; Abhimanyu Garg, MD OBJECTIVE —The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty...

..., microvascular complications, and depression. The role of altered fatty acid profiles in type 1 diabetic patients should be considered as well. Decsi et al. ( 2 ) found that type 1 diabetic patients have lower levels of long-chain polyunsaturated fatty acids (LCPUFAs). They speculate that this is because...

...Augustina M.A. Brands, MSC; Geert Jan Biessels, PHD, MD; Edward H.F. de Haan, PHD; L. Jaap Kappelle, PHD, MD; Roy P.C. Kessels, PHD References 1 Ross CM: Are fatty acids a link between diabetes and lowered cognitive performance? (Letter). Diabetes Care   28 : 2335 , 2005 2 Brands AMA...

... with insulin resistance. This study examined the effects of feeding monounsaturated, saturated, and trans fatty acids on insulin action in healthy adults. RESEARCH DESIGN AND METHODS —A randomized, double-blind, crossover study was conducted comparing three controlled 4-week diets (57% carbohydrate...

...Guenther Boden, MD We have demonstrated that physiological elevations in plasma free fatty acid concentrations inhibit insulin-stimulated glucose uptake in a dose-dependent manner in normal control subjects and in patients with NIDDM. Two possible mechanisms were identified: 1) a fat-related...

...Lloyd Axelrod, MD; Janice Camuso, RN; Ellen Williams, RD; Kenneth Kleinman, BA; Esperanza Briones, PHD; David Schoenfeld, PHD OBJECTIVE To study the effects of a low dose of ω-3 fatty acids on platelet function and other cardiovascular risk factors in patients with non-insulin-dependent diabetes...

...Toree H Malasanos, MD; Peter W Stacpoole, PhD, MD Fish oils exert important biological effects on several pathways predisposing to atherosclerosis. Epidemiological studies provided the initial evidence that omega-3 fatty acids may be the principal factor in fish oils responsible for these effects...

... greater at low dose and less at high dose. No significant difference between insulin types was found in the depression of non-esterified fatty acid (NEFA) concentrations, although significant differences between types with low-dose subcutaneous injection emerged during the later phases of the experiment...

...Qianyi Wang; Fumiaki Imamura; Wenjie Ma; Molin Wang; Rozenn N. Lemaitre; Irena B. King; Xiaoling Song; Mary L. Biggs; Joseph A. Delaney; Kenneth J. Mukamal; Luc Djousse; David S. Siscovick; Dariush Mozaffarian OBJECTIVE To investigate the effects of trans fatty acids (TFAs) on type 2...

...; Catherine Helmer; Johanna M. Geleijnse; Jason H.Y. Wu; Amanda Fretts; Rozenn N. Lemaitre; Renata Micha; Dariush Mozaffarian; Qi Sun OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize...

..., and sex. CONCLUSIONS These metabolomics results, together with the increased rates of in vivo FOX, are not supportive of defective fatty acid or amino acid metabolism in obesity and type 2 diabetes in youth. Such observations are consistent with early adaptive metabolic plasticity in youth, which over...

...José-Manuel Fernández-Real, MD, PHD; Montserrat Broch, PHD; Joan Vendrell, MD, PHD; Wifredo Ricart, MD OBJECTIVE —Fatty acids (FAs) have been involved in the development of chronic inflammatory conditions such as insulin resistance and obesity. However, the relation among insulin resistance...

...Magda S. Perassolo, BC; Jussara C. Almeida, RD; Ronivan L. Prá, BC; Vanessa D. Mello, RD; Ana L. Maia, MD; Cileide C. Moulin, RD; Joíza L. Camargo, MSC; Themis Zelmanovitz, MD; Mirela J. Azevedo, MD; Jorge L. Gross, MD OBJECTIVE —To determine the fatty acid composition of serum phospholipid...

...Katie A. Meyer, MPH; Lawrence H. Kushi, SCD; David R. Jacobs, Jr., PHD; Aaron R. Folsom, MD OBJECTIVE —To examine the associations between reported intakes of dietary fat and incident type 2 diabetes. RESEARCH DESIGN AND METHODS —We studied the relation between dietary fatty acids and diabetes...

...Sean A. Newsom, PHD; Allison C. Everett, BS; Alexander Hinko, PHD; Jeffrey F. Horowitz, PHD OBJECTIVE The purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults. RESEARCH DESIGN...

...David E. Kelley, MD; Bret H. Goodpaster, PHD Recent evidence derived from four independent methods indicates that an excess triglyceride storage within skeletal muscle is linked to insulin resistance. Potential mechanisms for this association include apparent defects in fatty acid metabolism...

...Charles F. Burant, MD, PHD The stimulation of insulin secretion by glucose can be modulated by multiple nutritive, hormonal, and pharmacological inputs. Fatty acids potentiate insulin secretion through the generation of intracellular signaling molecules and through the activation of cell surface...