Optimizing the management of glycemia, blood pressure, and lipids can reduce or slow the progression of microvascular complications of diabetes.
Diabetic Retinopathy (DR)
Screening
Recommended DR screenings can allow for timely treatment to prevent or reverse vision loss.
Neuropathy
Screening
All people with diabetes should be assessed for diabetic peripheral neuropathy (DPN):
Starting at the diagnosis of type 2 diabetes
5 years after the diagnosis of type 1 diabetes
At least annually thereafter
Symptoms and signs of autonomic neuropathy should be assessed:
Starting at the diagnosis of type 2 diabetes
5 years after the diagnosis of type 1 diabetes
At least annually thereafter
With evidence of other microvascular complications, particularly kidney disease and DPN
Treatment
Various drugs may reduce pain from DPN, and both drug and non-drug strategies may ease symptoms of DPN and autonomic neuropathy.
The safest and most evidence-based pharmacologic options for DPN include gabapentinoids, serotonin- norepinephrine reuptake inhibitors, tricyclic antidepressants, and sodium channel blockers.
Refer to a neurologist or pain specialist when pain control is not achieved within the scope of practice of the treating clinician.
Foot Care
Initial treatment recommendations should include:
Daily foot inspection
Use of moisturizers for dry, scaly skin and avoidance of self-care of ingrown nails and calluses
Well-fitted athletic or walking shoes with customized pressure-relieving orthoses for people with increased plantar pressures (e.g., with plantar calluses).
Risk Stratification and Screening Frequency

Adapted with permission from Schaper NC, van Netten JJ, Apelqvist J, Bus SA, Hinchliffe RJ; IWGDF Editorial Board. Practical guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev 2020;36(Suppl. 1):e3266. LOPS, loss of protective sensation. PAD, peripheral artery disease. Examination frequency suggestions are based on expert opinion and person-centered requirements.