Optimizing the management of glycemia, blood pressure, and lipids can reduce or slow the progression of microvascular complications of diabetes.

Screening

Recommended DR screenings can allow for timely treatment to prevent or reverse vision loss.

Screening

All people with diabetes should be assessed for diabetic peripheral neuropathy (DPN):

  • Starting at the diagnosis of type 2 diabetes

  • 5 years after the diagnosis of type 1 diabetes

  • At least annually thereafter

Symptoms and signs of autonomic neuropathy should be assessed:

  • Starting at the diagnosis of type 2 diabetes

  • 5 years after the diagnosis of type 1 diabetes

  • At least annually thereafter

  • With evidence of other microvascular complications, particularly kidney disease and DPN

Treatment

  • Various drugs may reduce pain from DPN, and both drug and non-drug strategies may ease symptoms of DPN and autonomic neuropathy.

  • The safest and most evidence-based pharmacologic options for DPN include gabapentinoids, serotonin- norepinephrine reuptake inhibitors, tricyclic antidepressants, and sodium channel blockers.

  • Refer to a neurologist or pain specialist when pain control is not achieved within the scope of practice of the treating clinician.

Initial treatment recommendations should include:

  • Daily foot inspection

  • Use of moisturizers for dry, scaly skin and avoidance of self-care of ingrown nails and calluses

  • Well-fitted athletic or walking shoes with customized pressure-relieving orthoses for people with increased plantar pressures (e.g., with plantar calluses).

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Adapted with permission from Schaper NC, van Netten JJ, Apelqvist J, Bus SA, Hinchliffe RJ; IWGDF Editorial Board. Practical guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update). Diabetes Metab Res Rev 2020;36(Suppl. 1):e3266. LOPS, loss of protective sensation. PAD, peripheral artery disease. Examination frequency suggestions are based on expert opinion and person-centered requirements.

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