Severe hypoglycemia (SH) is the most frequent and potentially serious complication affecting individuals with type 1 diabetes and can have major clinical and psychosocial consequences. Glucagon is the only approved treatment for SH that can be administered by non–health care professionals (HCPs); however, reports on the experiences and emotions of people with type 1 diabetes associated with SH and glucagon rescue use are limited. This survey study demonstrated that an increasing number of individuals with type 1 diabetes have current and filled prescriptions for glucagon and have been educated about glucagon rescue use by an HCP. Despite this positive trend, challenges with SH remain, including a high level of health care resource utilization, considerable out-of-pocket expenses for glucagon kits, a high prevalence of hypoglycemia unawareness, and a negative emotional impact on individuals with diabetes. Nocturnal and exercise-related hypoglycemia were concerns for most survey participants.
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March 06 2023
Severe Hypoglycemia and the Use of Glucagon Rescue Agents: An Observational Survey in Adults With Type 1 Diabetes
Allyson S. Hughes
;
1Department of Primary Care, Ohio University Heritage College of Osteopathic Medicine, Athens, OH
Corresponding author: Allyson S. Hughes, ashughes@ohio.edu
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Katherine S. Chapman;
Katherine S. Chapman
2T1D Exchange, Boston, MA
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Jeoffrey Bispham;
Jeoffrey Bispham
2T1D Exchange, Boston, MA
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Melissa Winget;
Melissa Winget
3Zealand Pharma A/S, Boston, MA
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Stuart A. Weinzimer;
Stuart A. Weinzimer
4Department of Pediatrics, Yale School of Medicine, New Haven, CT
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Wendy A. Wolf
Wendy A. Wolf
2T1D Exchange, Boston, MA
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J.L. is currently affiliated with Ironwood Pharmaceuticals, Boston, MA.
J.B. is currently affiliated with PatientsLikeMe, Boston, MA.
M.W. is currently affiliated with Market Access and RWE Consulting and Contract Services, Winget LLC, Boston, MA.
Corresponding author: Allyson S. Hughes, ashughes@ohio.edu
Clin Diabetes cd220099
Citation
Allyson S. Hughes, Katherine S. Chapman, Huyen Nguyen, Jingwen Liu, Jeoffrey Bispham, Melissa Winget, Stuart A. Weinzimer, Wendy A. Wolf; Severe Hypoglycemia and the Use of Glucagon Rescue Agents: An Observational Survey in Adults With Type 1 Diabetes. Clin Diabetes 2023; cd220099. https://doi.org/10.2337/cd22-0099
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