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Diabetes Paper of the Month

Each month, the Editor-in-Chief of Diabetes chooses a single paper to be designated as the Paper of the Month (POTM), which is then made available for free online and added to the exclusive POTM collection.
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Metabolism
A three-week ketogenic diet increases skeletal muscle insulin sensitivity in individuals with obesity – a randomized, controlled crossover trial
July 25 2024
https://doi.org/10.2337/db24-0162
Metabolism
Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia
June 13 2024
https://doi.org/10.2337/db24-0175
Genetics/Genomes/Proteomics/Metabolomics
Glucose Transporters Are Key Components of the Human Glucostat
May 22 2024
https://doi.org/10.2337/db23-0508
Islet Studies
Gut Microbiota−Tryptophan Metabolism−GLP-1 Axis Participates in β-Cell Regeneration Induced by Dapagliflozin
March 12 2024
https://doi.org/10.2337/db23-0553
Pharmacology and Therapeutics
Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
February 22 2024
https://doi.org/10.2337/db23-0568
Metabolism
High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans
November 28 2023
https://doi.org/10.2337/db23-0201
Metabolism
Adipocyte Glucocorticoid Receptor Activation With High Glucocorticoid Doses Impairs Healthy Adipose Tissue Expansion by Repressing Angiogenesis
November 14 2023
https://doi.org/10.2337/db23-0165
Pathophysiology
Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity
October 26 2023
https://doi.org/10.2337/db23-0009
Obesity Studies
Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis
October 17 2023
https://doi.org/10.2337/db23-0495
Metabolism
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation
September 12 2023
https://doi.org/10.2337/db22-1033
Islet Studies
Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery
August 25 2023
https://doi.org/10.2337/db23-0445
Islet Studies
Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells
July 26 2023
https://doi.org/10.2337/db23-0056
Metabolism
Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia
June 22 2023
https://doi.org/10.2337/db23-0139
Metabolism
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
May 24 2023
https://doi.org/10.2337/db22-0019
Complications
Hematopoietic NLRP3 and AIM2 Inflammasomes Promote Diabetes-Accelerated Atherosclerosis, but Increased Necrosis Is Independent of Pyroptosis
April 21 2023
https://doi.org/10.2337/db22-0962
Pharmacology and Therapeutics
Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
February 23 2023
https://doi.org/10.2337/db22-0515
Pathophysiology
Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients
January 19 2023
https://doi.org/10.2337/db22-0557
Metabolism
Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle
December 29 2022
https://doi.org/10.2337/db22-0590
Metabolism
The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery
December 07 2022
https://doi.org/10.2337/db22-0568
Obesity Studies
Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity
November 01 2022
https://doi.org/10.2337/db21-1072

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